Gene Expression Literature Summary

• Symbol: S100a4
• Name: S100 calcium binding protein A4
• ID: MGI:1330282

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)	1				1	2	4	1	2	3	1	5	1	4	1	14
In situ RNA (section)	1	1					1		2	2	1				1	1
Northern blot		1		1			1			1		1		1	1	3
Western blot														1		5
RT-PCR			1			1				2	1	1	1	1		5
cDNA clones				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

S100a4  S100 calcium binding protein A4   (Synonyms: 18A2, 42a, calvasculin, Capl, CAPL, Fibroblast-specific protein 1, FSp1, metastasin, Mts1, PeL98, pk9a)
Results	Reference
1	J:204445 Andersen DC, Laborda J, Baladron V, Kassem M, Sheikh SP, Jensen CH, Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013 Sep;140(18):3743-53
2	J:224431 Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR, Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73
3	J:205073 Cano E, Carmona R, Munoz-Chapuli R, Wt1-expressing progenitors contribute to multiple tissues in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L322-32
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:251273 Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Volkers M, S100A4 protects the myocardium against ischemic stress. J Mol Cell Cardiol. 2016 Nov;100:54-63
1	J:264144 Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ, A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7:e34110
1	J:345073 Eley L, Richardson RV, Alqahtani A, Chaudhry B, Henderson DJ, eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling. Dis Model Mech. 2024 Jan 1;17(1)
2*	J:115165 Hecht J, Seitz V, Urban M, Wagner F, Robinson PN, Stiege A, Dieterich C, Kornak U, Wilkening U, Brieske N, Zwingman C, Kidess A, Stricker S, Mundlos S, Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Gene Expr Patterns. 2007 Jan;7(1-2):102-12
1	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:146619 Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D, Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb;16(2):233-44
4	J:70451 Ito M, Kizawa K, Expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with the onset of hair follicle regeneration. J Invest Dermatol. 2001 Jun;116(6):956-63
9	J:27240 Jackson-Grusby LL, Swiergiel J, Linzer DI, A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein. Nucleic Acids Res. 1987 Aug 25;15(16):6677-90
1	J:173588 Kanazawa T, Ichii O, Otsuka S, Namiki Y, Hashimoto Y, Kon Y, Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice. J Vet Med Sci. 2011 May;73(5):601-7
11	J:43267 Klingelhofer J, Ambartsumian NS, Lukanidin EM, Expression of the metastasis-associated mts1 gene during mouse development. Dev Dyn. 1997 Oct;210(2):87-95
1	J:117058 Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG, Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Development. 2007 Jan;134(2):261-72
1*	J:170203 Lague MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D, Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E936-46
2*	J:250161 Lee AJ, Polgar N, Napoli JA, Lui VH, Tamashiro KK, Fujimoto BA, Thompson KS, Fogelgren B, Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Sci Rep. 2016 Aug 11;6:31137
1	J:306873 Li L, Jin J, Yang XJ, Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells. iScience. 2019 Oct 25;20:148-167
2	J:202226 Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH, Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1;382(1):110-23
4	J:195172 Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A, Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 2013 Jan;9(1):e1003189
6	J:301112 Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV, Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
1	J:216376 Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M, Suzuki A, Enomoto K, Nishikawa Y, Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol. 2014;184(11):3001-12
1	J:347984 Naillat F, Deshar G, Hankkila A, Rak-Raszewska A, Sharma A, Prunskaite-Hyyrylainen R, Railo A, Shan J, Vainio SJ, Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
1	J:195536 Ojala JR, Pikkarainen T, Elmberger G, Tryggvason K, Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice. Am J Pathol. 2013 May;182(5):1681-95
1*	J:202837 Rowton M, Ramos P, Anderson DM, Rhee JM, Cunliffe HE, Rawls A, Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013 Nov;242(11):1332-44
6*	J:26830 Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG, Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995 Jul;130(2):393-405
3	J:277548 Takahara S, Inoue SI, Miyagawa-Tomita S, Matsuura K, Nakashima Y, Niihori T, Matsubara Y, Saiki Y, Aoki Y, New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to beta-adrenergic stimulation-induced cardiac fibrosis. EBioMedicine. 2019 Apr;42:43-53
2	J:154337 Touma SE, Perner S, Rubin MA, Nanus DM, Gudas LJ, Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. Biochem Pharmacol. 2009 Nov 1;78(9):1127-38
1	J:217680 Trembley MA, Velasquez LS, de Mesy Bentley KL, Small EM, Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development. 2015 Jan 1;142(1):21-30
4	J:340973 Wojahn I, Ludtke TH, Christoffels VM, Trowe MO, Kispert A, TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung. Respir Res. 2019 Dec 23;20(1):292
2	J:311873 Ye S, Yang N, Lu T, Wu T, Wang L, Pan YH, Cao X, Yuan X, Wisniewski T, Dang S, Zhang W, Adamts18 modulates the development of the aortic arch and common carotid artery. iScience. 2021 Jun 25;24(6):102672
1	J:262529 Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B, Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res. 2017 Sep;27(9):1157-1177