Gene Expression Literature Summary

• Symbol: Elf5
• Name: E74-like factor 5
• ID: MGI:1335079

42 matching records from 42 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E5.5	E6.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)	1	1	2		1								1				2	1		1		1		1			3
In situ RNA (section)					3						2				3		3	3		1		2		2			5
In situ RNA (whole mount)		2	6	1	3	1			1		1				1		1	2
In situ reporter (knock in)																				1				1			2
Northern blot							1	1		1		1		1		1			1		1		1		1		1
Western blot																				1							2
RT-PCR	1		3			1	1		1		2						4	2		2		1		5		1	6
cDNA clones																1											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Elf5  E74-like factor 5   (Synonyms: ESE-2)
Results	Reference
2*	J:310134 Adachi K, Nikaido I, Ohta H, Ohtsuka S, Ura H, Kadota M, Wakayama T, Ueda HR, Niwa H, Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol Cell. 2013 Nov 7;52(3):380-92
1	J:341713 Aure MH, Symonds JM, Villapudua CU, Dodge JT, Werner S, Knosp WM, Hoffman MP, FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation. Nat Commun. 2023 Oct 14;14(1):6485
2	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
1	J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322
1	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
4*	J:169890 Choi YS, Cheng J, Segre J, Sinha S, Generation and analysis of Elf5-LacZ mouse: unique and dynamic expression of Elf5 (ESE-2) in the inner root sheath of cycling hair follicles. Histochem Cell Biol. 2008 Jan;129(1):85-94
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:329048 Deuper L, Meuser M, Thiesler H, Jany UWH, Rudat C, Hildebrandt H, Trowe MO, Kispert A, Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling. Development. 2022 Sep 1;149(17):dev200767
1*	J:263987 Dobreva MP, Abon Escalona V, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A, Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling. Development. 2018 Jul 2;145(13):dev157222
6	J:98382 Donnison M, Beaton A, Davey HW, Broadhurst R, L'huillier P, Pfeffer PL, Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. Development. 2005 May;132(10):2299-308
3	J:218169 Donnison M, Broadhurst R, Pfeffer PL, Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015 Jan 1;397(1):77-88
3	J:241013 Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, Visvader JE, Zhao H, Fogarty E, Surendran K, Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017 Apr 01;424(1):77-89
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
1	J:324027 Kappen C, Kruger C, Jones S, Salbaum JM, Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy. Front Cell Dev Biol. 2022;10:777844
5*	J:266596 Kersbergen A, Best SA, Dworkin S, Ah-Cann C, de Vries ME, Asselin-Labat ML, Ritchie ME, Jane SM, Sutherland KD, Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs. Dev Biol. 2018 Nov 1;443(1):1-9
3	J:125767 Kobberup S, Nyeng P, Juhl K, Hutton J, Jensen J, ETS-family genes in pancreatic development. Dev Dyn. 2007 Nov;236(11):3100-10
4*	J:261408 Kong S, Liang G, Tu Z, Chen D, Wang H, Lu J, Generation of Elf5-Cre knockin mouse strain for trophoblast-specific gene manipulation. Genesis. 2018 Apr;56(4):e23101
2	J:223226 Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y, Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. J Cell Sci. 2015 Mar 1;128(5):1011-22
1*	J:227118 Latos PA, Sienerth AR, Murray A, Senner CE, Muto M, Ikawa M, Oxley D, Burge S, Cox BJ, Hemberger M, Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Genes Dev. 2015 Dec 1;29(23):2435-48
1*	J:245622 Madon-Simon M, Grad I, Bayo P, Perez P, Picard D, Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. PLoS One. 2017;12(6):e0180035
1	J:176435 Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB, The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011 Sep 1;25(17):1871-80
6	J:139210 Metzger DE, Stahlman MT, Shannon JM, Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol. 2008 Aug 1;320(1):149-60
8*	J:120879 Metzger DE, Xu Y, Shannon JM, Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev Dyn. 2007 May;236(5):1175-92
3	J:321503 Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P, Hildebrandt H, Trowe MO, Kispert A, FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
1	J:145789 Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M, Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol. 2008 Nov;10(11):1280-90
1*	J:203737 Oda M, Oxley D, Dean W, Reik W, Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013;8(6):e68846
1	J:243715 Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg MW, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M, Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015 Oct;67(10):2679-90
1*	J:282332 Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J, Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Dev Biol. 2019 Nov 15;455(2):382-392
1	J:184505 Oliver CH, Khaled WT, Frend H, Nichols J, Watson CJ, The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012 May 15;26(10):1086-97
2	J:183999 Ouseph MM, Li J, Chen HZ, Pecot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G, Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
2*	J:178704 Pearton DJ, Broadhurst R, Donnison M, Pfeffer PL, Elf5 regulation in the trophectoderm. Dev Biol. 2011 Dec 15;360(2):343-50
2	J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
1	J:168262 Romano RA, Smalley K, Liu S, Sinha S, Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development. 2010 May;137(9):1431-9
1	J:179397 Schachterle W, Rojas A, Xu SM, Black BL, ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49
5	J:182938 Sevilla LM, Bayo P, Latorre V, Sanchis A, Perez P, Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Mol Endocrinol. 2010 Nov;24(11):2166-78
1	J:196481 Sevilla LM, Latorre V, Sanchis A, Perez P, Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation. J Invest Dermatol. 2013 Feb;133(2):361-70
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
13*	J:51385 Zhou J, NG AY, Tymms MJ, Jermiin LS, Seth AK, Thomas RS, Kola I, A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene. 1998 Nov 26;17(21):2719-32
2	J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14