Gene Expression Literature Summary

• Symbol: Irs4
• Name: insulin receptor substrate 4
• ID: MGI:1338009

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E18.5	P
Immunohistochemistry (section)		1		1	1	1	1					1
In situ RNA (section)				2	2	1	1		2	1		3	5
In situ RNA (whole mount)						2
In situ reporter (knock in)													1
Western blot													1
RT-PCR	1		1	1		1	1	1			1		4
cDNA clones				1									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Irs4  insulin receptor substrate 4   (Synonyms: IRS-4)
Results	Reference
1*	J:100830 Bischof JM, Wevrick R, Genome-wide analysis of gene transcription in the hypothalamus. Physiol Genomics. 2005 Jul 14;22(2):191-6
1*	J:156788 Bouma GJ, Hudson QJ, Washburn LL, Eicher EM, New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod. 2010 Feb;82(2):380-9
1	J:184234 Chirivella L, Cano-Jaimez M, Perez-Sanchez F, Herraez L, Carretero J, Farinas I, Burks DJ, Kirstein M, IRS2 signalling is required for the development of a subset of sensory spinal neurons. Eur J Neurosci. 2012 Feb;35(3):341-52
1*	J:165759 Chiu HS, Szucsik JC, Georgas KM, Jones JL, Rumballe BA, Tang D, Grimmond SM, Lewis AG, Aronow BJ, Lessard JL, Little MH, Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol. 2010 Aug 15;344(2):1071-87
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
6	J:255808 Dorpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P, IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci Rep. 2017 Aug 18;7(1):8778
1	J:358820 Dudukcu O, Raj DDA, van de Haar LL, Grossouw LM, Linders LE, Garritsen O, Adolfs Y, van Kronenburg NCH, Broekhoven MH, Kapteijns THW, Meye FJ, Pasterkamp RJ, Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. 2024 Nov 15;27(11):111239
7*	J:53778 Fantin VR, Lavan BE, Wang Q, Jenkins NA, Gilbert DJ, Copeland NG , Keller SR , Lienhard GE, Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. Endocrinology. 1999 Mar;140(3):1329-37
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:308430 Lopez-Gonzalez L, Alonso A, Garcia-Calero E, de Puelles E, Puelles L, Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling. Front Cell Dev Biol. 2021;9:676121
1	J:279058 Seifinejad A, Li S, Mikhail C, Vassalli A, Pradervand S, Arribat Y, Pezeshgi Modarres H, Allen B, John RM, Amati F, Tafti M, Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17061-17070
2*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
4*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
2*	J:299851 Sutton AK, Gonzalez IE, Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, Olson DP, Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance. Sci Rep. 2020 Mar 26;10(1):5546
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:151233 Trimarchi JM, Cho SH, Cepko CL, Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep;238(9):2327-9