Gene Expression Literature Summary

• Symbol: Hic1
• Name: hypermethylated in cancer 1
• ID: MGI:1338010

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E18	E18.5	P
Immunohistochemistry (section)					1	1							1		1	1
In situ RNA (section)								1		1	3	1	4				3
In situ RNA (whole mount)	1	1	1	1		3		1		1	1			3
In situ reporter (knock in)						1	1	2	1	3	2		2	1		1	1
Northern blot																	1
Western blot										1
RT-PCR						1			1	1			1			1	2
cDNA clones							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hic1  hypermethylated in cancer 1   (Synonyms: HIC-1)
Results	Reference
6	J:327968 Arostegui M, Wilder Scott R, Bose K, Michael Underhill T, Cellular taxonomy of Hic1(+) mesenchymal progenitor derivatives in the limb: from embryo to adult. Nat Commun. 2022 Aug 25;13(1):4989
1	J:81448 Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB, Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet. 2003 Feb;33(2):197-202
1*	J:116022 Coveney D, Ross AJ, Slone JD, Capel B, A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.(Correction: 2008; 8:529-537). Gene Expr Patterns. 2007 Jan;7(1-2):82-92
1*	J:225226 Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ, HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
1	J:332217 Feng J, Han X, Yuan Y, Cho CK, Janeckova E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y, TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. Elife. 2022 Dec 21;11
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
15*	J:54410 Grimm C, Sporle R, Schmid TE, Adler ID, Adamski J, Schughart K , Graw J, Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Hum Mol Genet. 1999 Apr;8(4):697-710
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:300927 Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho CK, Li J, Jing J, Janeckova E, He J, Pei F, Bi J, Song B, Chai Y, Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. Elife. 2021 Jan 22;10:e62387
2	J:340446 Lotto J, Cullum R, Drissler S, Arostegui M, Garside VC, Fuglerud BM, Clement-Ranney M, Thakur A, Underhill TM, Hoodless PA, Cell diversity and plasticity during atrioventricular heart valve EMTs. Nat Commun. 2023 Sep 9;14(1):5567
1	J:308922 Medeiros de Araujo JA, Barao S, Mateos-White I, Espinosa A, Costa MR, Gil-Sanz C, Muller U, ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development. 2021 Aug 15;148(16):dev196642
15*	J:170337 Pospichalova V, Tureckova J, Fafilek B, Vojtechova M, Krausova M, Lukas J, Sloncova E, Takacova S, Divoky V, Leprince D, Plachy J, Korinek V, Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis. 2011 Mar;49(3):142-51
1	J:69868 Sporle R, Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication. Dev Genes Evol. 2001 Apr;211(4):198-217
1	J:119022 Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V, HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J. 2006 Jun 7;25(11):2326-37
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:203752 Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L, Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol. 2013 May;33(9):1845-58
1	J:168266 Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN, A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene. 2010 Apr 29;29(17):2467-76