Gene Expression Literature Summary

• Symbol: Ikbkb
• Name: inhibitor of kappaB kinase beta
• ID: MGI:1338071

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E9.5	E10	E11	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)																	2		1	2
In situ RNA (section)		1	1		1	1	1	1	1	1		1							1	1
In situ RNA (whole mount)						1						1
Northern blot	1			1							1			1						1
Western blot						1				1						1				2
RT-PCR												1	1		2		1	1		3
cDNA clones					1															1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ikbkb  inhibitor of kappaB kinase beta   (Synonyms: IKK-2, IKK2, IKK[b], IKK-beta, IKKbeta)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:228639 Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterkova R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramirez A, Sharpe PT, Ohazama A, Excess NF-kappaB induces ectopic odontogenesis in embryonic incisor epithelium. J Dent Res. 2015 Jan;94(1):121-8
1	J:129793 Cascallana JL, Bravo A, Donet E, Leis H, Lara MF, Paramio JM, Jorcano JL, Perez P, Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia. Endocrinology. 2005 Jun;146(6):2629-38
1	J:240181 Chen LY, Yang-Yen HF, Tsai CC, Thio CL, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, Chang YJ, Chen YT, Yen JJ, Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. J Invest Dermatol. 2017 Apr;137(4):894-904
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:139642 Hou Y, Li F, Karin M, Ostrowski MC, Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Sep 24;237(10):2926-2935
4*	J:52114 Hu MC, Wang Y, IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. Gene. 1998 Nov 5;222(1):31-40
6	J:58020 Hu MC, Wang Yp, Qiu WR, Mikhail A, Meyer CF, Tan TH, Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase. Oncogene. 1999 Sep 30;18(40):5514-24
1*	J:54316 Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M, Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase [see comments]. Science. 1999 Apr 9;284(5412):316-20
2	J:283314 Kraut B, Maier HJ, Kokai E, Fiedler K, Boettger T, Illing A, Kostin S, Walther P, Braun T, Wirth T, Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. PLoS One. 2015;10(11):e0141591
1	J:316483 Leek CC, Soulas JM, Bhattacharya I, Ganji E, Locke RC, Smith MC, Bhavsar JD, Polson SW, Ornitz DM, Killian ML, Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn. 2021 Dec;250(12):1778-1795
2	J:181392 Londhe VA, Maisonet TM, Lopez B, Jeng JM, Xiao J, Li C, Minoo P, Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011;12:134
6	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
6	J:90053 Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT, A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb;6(2):219-27
1	J:305434 Scovell JM, Bournat JC, Szafran AT, Solis M, Moore J, Rivera A, Chen CH, Zhang J, Wilken N, Seth A, Jorgez CJ, PRSS50 is a testis protease responsible for proper sperm tail formation and function. Development. 2021 Apr 15;148(8):dev197558
1*	J:325727 Sugioka S, Ikeda S, Harada M, Kishihata M, Al-Huseini I, Kimura T, Ashida N, Effects of constitutively active IKKbeta on cardiac development. Biochem Biophys Res Commun. 2022 Jul 23;614:169-174
2	J:54315 Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S, Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6