Gene Expression Literature Summary

• Symbol: Mthfd2
• Name: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
• ID: MGI:1338850

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E5.5	E6.5	E7	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	P
In situ RNA (section)								1							2
In situ RNA (whole mount)								2	1
In situ reporter (knock in)																						1
Northern blot	1	1	1	1	1	1		1	1	1	1	1		1	1	1	1	1	1	1	1
RT-PCR						1	1	1	1	1	3	1	1	3		1	1		1	1		4
cDNA clones											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mthfd2  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase   (Synonyms: NMDMC)
Results	Reference
1	J:63377 Abidari JM, Gonzales ET, Inoue K, Lupski JR, Karsenty G, Katsanis N, Identification of novel genes expressed during metanephric induction through single-cell library screening. Kidney Int. 2000 Jun;57(6):2221-8
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7*	J:115488 Di Pietro E, Wang XL, MacKenzie RE, The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth. Biochim Biophys Acta. 2004 Sep 6;1674(1):78-84
1*	J:241343 Furuya S, Yoshida K, Kawakami Y, Yang JH, Sayano T, Azuma N, Tanaka H, Kuhara S, Hirabayashi Y, Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct Integr Genomics. 2008 Aug;8(3):235-49
2*	J:333714 Huynh H, Zhu S, Lee S, Bao Y, Pang J, Nguyen A, Gu Y, Chen C, Ouyang K, Evans SM, Fang X, DELE1 is protective for mitochondrial cardiomyopathy. J Mol Cell Cardiol. 2023 Feb;175:44-48
6*	J:312368 Imbard A, Schwendimann L, Lebon S, Gressens P, Blom HJ, Benoist JF, Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:253948 Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD, Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol. 2016 Aug;97:1-14
16*	J:159942 Pike ST, Rajendra R, Artzt K, Appling DR, Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. J Biol Chem. 2010 Feb 12;285(7):4612-20
9*	J:214110 Shin M, Bryant JD, Momb J, Appling DR, Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues. J Biol Chem. 2014 May 30;289(22):15507-17
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:335524 Zhu S, Nguyen A, Pang J, Zhao J, Chen Z, Liang Z, Gu Y, Huynh H, Bao Y, Lee S, Kluger Y, Ouyang K, Evans SM, Fang X, Mitochondrial Stress Induces an HRI-eIF2alpha Pathway Protective for Cardiomyopathy. Circulation. 2022 Sep 27;146(13):1028-1031