Gene Expression Literature Summary

• Symbol: Csf1
• Name: colony stimulating factor 1 (macrophage)
• ID: MGI:1339753

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E2	E2.5	E3	E4	E5.5	E6.5	E8.5	E9.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)						1	1				1		1	1		1				1				3
In situ RNA (section)										1			1		1	1	1	1	1	1		2		4
Northern blot															1			1			1	1	1	3
RT-PCR	1	1	1	1	1	1	1	2	2	5			1			2	2	2		1		3		9
Nuclease S1												1							1					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Csf1  colony stimulating factor 1 (macrophage)   (Synonyms: BAP025, colony-stimulating factor-1, CSF-1, Csfm, M-CSF)
Results	Reference
1	J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72
5	J:757 Arceci RJ, Pampfer S, Pollard JW, Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development. Dev Biol. 1992 May;151(1):1-8
1	J:261653 Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO, Muscularis macrophage development in the absence of an enteric nervous system. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701
1*	J:17727 Burns TM, Clough JA, Klein RM, Wood GW, Berman NE, Developmental regulation of cytokine expression in the mouse brain. Growth Factors. 1993;9(4):253-8
3*	J:19249 Chang Y, Albright S, Lee F, Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol. 1994 Jun;52(1):9-17
1*	J:16945 Cheng HL, Schneider SL, Kane CM, Gollnick SO, Grande C, Thompson D, Pietrzak E, Tomasi TB, TGF-beta 2 gene and protein expression in maternal and fetal tissues at various stages of murine development. J Reprod Immunol. 1993 Nov;25(2):133-48
2	J:314283 Duan RN, Yang CL, Du T, Liu A, Wang AR, Sun WJ, Li X, Li JX, Yan CZ, Liu QJ, Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway. J Neuroinflammation. 2021 Jun 28;18(1):145
1	J:163512 Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S, Peri F, Wilson SW, Ruhrberg C, Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. 2010 Aug 5;116(5):829-40
1*	J:51348 Gao YH, Shinki T, Yuasa T, Kataoka-Enomoto H, Komori T, Suda T, Yamaguchi A, Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF). Biochem Biophys Res Commun. 1998 Nov 27;252(3):697-702
6	J:292336 Goolam M, Xypolita ME, Costello I, Lydon JP, DeMayo FJ, Bikoff EK, Robertson EJ, Mould AW, The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice. Nat Commun. 2020 Jun 3;11(1):2782
3*	J:37431 Harrington M, Konicek BW, Xia XL, Song A, Transcriptional regulation of the mouse CSF-1 gene. Mol Reprod Dev. 1997 Jan;46(1):39-44
4	J:29130 Hofstetter W, Wetterwald A, Cecchini MG, Mueller C, Felix R, Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development. Bone. 1995 Aug;17(2):145-51
1	J:357895 Houchen CJ, Ghanem S, Kaartinen V, Bumann EE, TGF-beta signaling in the cranial neural crest affects late-stage mandibular bone resorption and length. Front Physiol. 2024;15:1435594
3	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1*	J:230169 Isaac J, Erthal J, Gordon J, Duverger O, Sun HW, Lichtler AC, Stein GS, Lian JB, Morasso MI, DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ. 2014 Sep;21(9):1365-76
2	J:178369 Iwasaki Y, Otsuka H, Yanagisawa N, Hisamitsu H, Manabe A, Nonaka N, Nakamura M, In situ proliferation and differentiation of macrophages in dental pulp. Cell Tissue Res. 2011 Oct;346(1):99-109
3*	J:45357 Jemtland R, Lee K, Segre GV, Heterogeneity among cells that express osteoclast-associated genes in developing bone. Endocrinology. 1998 Jan;139(1):340-9
4*	J:36245 McClanahan T, Culpepper J, Campbell D, Wagner J, Franz-Bacon K, Mattson J, Tsai S, Luh J, Guimaraes MJ, Mattei MG, Rosnet O, Birnbaum D, Hannum CH, Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand. Blood. 1996 Nov 1;88(9):3371-82
2*	J:50937 Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M, AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93
1	J:168860 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE, Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug;28(8):1424-34
2	J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
3*	J:33690 Roth P, Stanley ER, Colony stimulating factor-1 expression is developmentally regulated in the mouse. J Leukoc Biol. 1996 Jun;59(6):817-23
4	J:249590 Sathi GA, Farahat M, Hara ES, Taketa H, Nagatsuka H, Kuboki T, Matsumoto T, MCSF orchestrates branching morphogenesis in developing submandibular gland tissue. J Cell Sci. 2017 May 01;130(9):1559-1569
1	J:205284 Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM, Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013 Nov 21;155(5):1119-30
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:183534 Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F, Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012 Mar;8(3):e1002577
1	J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
1	J:212391 Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F, Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
1	J:234684 Wang Y, Bugatti M, Ulland TK, Vermi W, Gilfillan S, Colonna M, Nonredundant roles of keratinocyte-derived IL-34 and neutrophil-derived CSF1 in Langerhans cell renewal in the steady state and during inflammation. Eur J Immunol. 2016 Mar;46(3):552-9
6*	J:164923 Wei S, Nandi S, Chitu V, Yeung YG, Yu W, Huang M, Williams LT, Lin H, Stanley ER, Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol. 2010 Sep;88(3):495-505