Gene Expression Literature Summary

• Symbol: Pak2
• Name: p21 (RAC1) activated kinase 2
• ID: MGI:1339984

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)				1	1	1	2	1	2
Western blot	1			2	1	1	3	3	8
RT-PCR		1	1		1			1	4
cDNA clones			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pak2  p21 (RAC1) activated kinase 2   (Synonyms: 5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2)
Results	Reference
1	J:55429 Burbelo PD, Kozak CA, Finegold AA, Hall A, Pirone DM, Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes. Gene. 1999 May 31;232(2):209-15
1	J:143322 Chen Y, Stump RJ, Lovicu FJ, Shimono A, McAvoy JW, Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Dev Biol. 2008 Dec 1;324(1):161-76
8*	J:158222 Demyanenko GP, Halberstadt AI, Rao RS, Maness PF, CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons. Neuroscience. 2010 Jan 13;165(1):107-15
3	J:157099 Grimsley-Myers CM, Sipe CW, Geleoc GS, Lu X, The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci. 2009 Dec 16;29(50):15859-69
1*	J:303862 Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K, Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Mol Brain. 2021 Jan 22;14(1):21
3	J:79013 Hayashi K, Ohshima T, Mikoshiba K, Pak1 is involved in dendrite initiation as a downstream effector of rac1 in cortical neurons. Mol Cell Neurosci. 2002 Aug;20(4):579
3*	J:357470 Hu B, Moiseev D, Schena I, Faezov B, Dunbrack R, Chernoff J, Li J, PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821
1*	J:157948 Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD, Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet. 2010 Apr 1;19(7):1347-57
1	J:138645 Kreis P, Rousseau V, Thevenot E, Combeau G, Barnier JV, The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties. J Neurochem. 2008 Aug;106(3):1184-97
1*	J:85956 Li X, Minden A, Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol. 2003 Oct;23(20):7134-42
1*	J:171914 Marlin JW, Chang YW, Ober M, Handy A, Xu W, Jakobi R, Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34. Mamm Genome. 2011 Jun;22(5-6):306-17
4	J:209016 Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G, Pak3 promotes cell cycle exit and differentiation of beta-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014 Jan;63(1):203-15
2	J:185948 Rosario M, Schuster S, Juttner R, Parthasarathy S, Tarabykin V, Birchmeier W, Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. Genes Dev. 2012 Aug 1;26(15):1743-57
2	J:294006 Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG, Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Mol Psychiatry. 2019;
1	J:195272 Sipe CW, Liu L, Lee J, Grimsley-Myers C, Lu X, Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development. 2013 Apr;140(8):1785-95
1	J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
1	J:276133 Yang CY, Yu TH, Wen WL, Ling P, Hsu KS, Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation. J Neurosci. 2019 Jun 19;39(25):4959-4975
1	J:280168 Zhu C, Cheng C, Wang Y, Muhammad W, Liu S, Zhu W, Shao B, Zhang Z, Yan X, He Q, Xu Z, Yu C, Qian X, Lu L, Zhang S, Zhang Y, Xiong W, Gao X, Xu Z, Chai R, Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice. Front Mol Neurosci. 2018;11:362