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Gene Expression Literature Summary
Symbol
Name
ID
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E6.5 E7.5 E8 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 1 2 2 2 1 3 1 4 1 2 5 2 1 9
In situ RNA (section) 4 3 1 4 6 8 1 1 1 2 4 7
In situ RNA (whole mount) 1 1 1
Western blot 2 1 3 1 1 1 5
RT-PCR 1 1 1 1 1 5
cDNA clones 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Lrp8  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor   (Synonyms: 4932703M08Rik, apoER2, Lr8b)
Results  Reference
1J:109820 Arnaud L, Ballif BA, Forster E, Cooper JA, Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003 Jan 8;13(1):9-17
4*J:114610 Baba K, Dekimoto H, Muraoka D, Agata K, Terashima T, Katsuyama Y, A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal. Biochem Biophys Res Commun. 2006 Dec 1;350(4):842-9
1J:317050 Bayam E, Sahin GS, Guzelsoy G, Guner G, Kabakcioglu A, Ince-Dunn G, Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation. BMC Genomics. 2015 Sep 5;16:681
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977
3*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1J:109819 Bock HH, Herz J, Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003 Jan 8;13(1):18-26
1J:208337 Bodea GO, Spille JH, Abe P, Andersson AS, Acker-Palmer A, Stumm R, Kubitscheck U, Blaess S, Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development. 2014 Feb;141(3):661-73
4J:216630 Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W, Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration. FASEB J. 2014 Aug;28(8):3579-88
3J:203560 Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S, Maternal-fetal transfer of selenium in the mouse. FASEB J. 2013 Aug;27(8):3249-56
1J:207796 Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kroger S, Johnson EB, Hammer RE, Lin W, Herz J, APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
2J:310452 Dairaghi L, Flannery E, Giacobini P, Saglam A, Saadi H, Constantin S, Casoni F, Howell BW, Wray S, Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway. Front Cell Neurosci. 2018;12:228
1J:88445 Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, Azoulai D, Reiner O, DCX, a new mediator of the JNK pathway. EMBO J. 2004 Feb 25;23(4):823-32
1J:181631 Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL, The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev. 2012 Mar 1;26(5):445-60
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*J:308689 Gyllborg D, Ahmed M, Toledo EM, Theofilopoulos S, Yang S, Ffrench-Constant C, Arenas E, The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation. Stem Cell Reports. 2018 Sep 11;11(3):651-664
4J:126335 Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, Frotscher M, Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007 Nov;134(21):3883-91
1J:70189 Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL, Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb;29(2):353-66
5J:149168 Hibi T, Mizutani M, Baba A, Hattori M, Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin. Neurosci Res. 2009 Apr;63(4):251-8
7J:219839 Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto TT, Nakajima K, Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015 Feb 15;523(3):463-78
1*J:138815 Kawaguchi A, Ikawa T, Kasukawa T, Ueda HR, Kurimoto K, Saitou M, Matsuzaki F, Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Development. 2008 Sep;135(18):3113-24
1J:170124 Khialeeva E, Lane TF, Carpenter EM, Disruption of reelin signaling alters mammary gland morphogenesis. Development. 2011 Feb;138(4):767-76
3J:299731 Kohno T, Ishii K, Hirota Y, Honda T, Makino M, Kawasaki T, Nakajima K, Hattori M, Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner. J Neurosci. 2020 Oct 21;40(43):8248-8261
1J:123312 Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato SB, Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1815-23
2*J:98484 Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J, Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun;132(11):2599-609
3J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011 Mar;240(3):577-88
3*J:82121 Luque JM, Morante-Oria J, Fairen A, Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res. 2003 Feb 16;140(2):195-203
1*J:74630 Magdaleno S, Keshvara L, Curran T, Rescue of Ataxia and Preplate Splitting by Ectopic Expression of Reelin in reeler Mice. Neuron. 2002 Feb 14;33(4):573-86
1*J:74989 McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG, Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002 Feb 22;295(5559):1528-32
1*J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2J:164005 Miyata T, Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A, Hashimoto M, Ogawa M, Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. Neural Dev. 2010;5:23
2J:133475 Nakamura M, Ishikawa O, The localization of label-retaining cells in mouse nails. J Invest Dermatol. 2008 Mar;128(3):728-30
2J:208769 Nakatani T, Minaki Y, Kumai M, Nitta C, Ono Y, The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. 2014 Apr 1;388(1):68-80
1J:293055 Okugawa E, Ogino H, Shigenobu T, Yamakage Y, Tsuiji H, Oishi H, Kohno T, Hattori M, Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice. Sci Rep. 2020 Mar 11;10(1):4471
3J:353305 Oshima K, Yoshinaga S, Kitazawa A, Hirota Y, Nakajima K, Kubo KI, A Unique "Reversed" Migration of Neurons in the Developing Claustrum. J Neurosci. 2023 Feb 1;43(5):693-708
1J:166792 Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A, Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010;8(8):e1000446
5J:101281 Perez-Garcia CG, Tissir F, Goffinet AM, Meyer G, Reelin receptors in developing laminated brain structures of mouse and human. Eur J Neurosci. 2004 Nov;20(10):2827-32
3J:97218 Rossel M, Loulier K, Feuillet C, Alonso S, Carroll P, Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development. 2005 Mar;132(6):1175-85
4J:171375 Senturk A, Pfennig S, Weiss A, Burk K, Acker-Palmer A, Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature. 2011 Apr 21;472(7343):356-60
2J:309447 Sharaf A, Rahhal B, Spittau B, Roussa E, Localization of reelin signaling pathway components in murine midbrain and striatum. Cell Tissue Res. 2015 Feb;359(2):393-407
1J:264182 Shehabeldin R, Lutz D, Karsak M, Frotscher M, Krieglstein K, Sharaf A, Reelin controls the positioning of brainstem serotonergic raphe neurons. PLoS One. 2018;13(7):e0200268
2J:162071 Tan XJ, Fan XT, Kim HJ, Butler R, Webb P, Warner M, Gustafsson JA, Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12305-10
3J:277380 Telley L, Agirman G, Prados J, Amberg N, Fievre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D, Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440)
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*J:55691 Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W , Nimpf J , Hammer RE , Richardson JA , Herz J, Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999 Jun 11;97(6):689-701
2J:152314 Uchida T, Baba A, Perez-Martinez FJ, Hibi T, Miyata T, Luque JM, Nakajima K, Hattori M, Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 2009 Aug 26;29(34):10653-62
1J:263687 Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, Jiang GB, Wang HL, Tong WM, Li W, Wang XJ, Yang YG, Zhou Q, METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol. 2018 Jun;16(6):e2004880
1J:163165 Yano M, Hayakawa-Yano Y, Mele A, Darnell RB, Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron. 2010 Jun 24;66(6):848-58
2J:88816 Yip YP, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, Yip JW, Components of the reelin signaling pathway are expressed in the spinal cord. J Comp Neurol. 2004 Mar 1;470(2):210-9

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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory