Gene Expression Literature Summary

• Symbol: Eif2ak3
• Name: eukaryotic translation initiation factor 2 alpha kinase 3
• ID: MGI:1341830

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E18.5	E	P
Immunohistochemistry (section)					1	1	1	1		2	1		1
In situ RNA (section)								3		1			1
Western blot	2	3	1	3	1	2	1	1	1		2	1	6
RT-PCR		1				1		2	1	2	1		5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Eif2ak3  eukaryotic translation initiation factor 2 alpha kinase 3   (Synonyms: PERK)
Results	Reference
1	J:281567 Ariyasu D, Kubo E, Higa D, Shibata S, Takaoka Y, Sugimoto M, Imaizumi K, Hasegawa T, Araki K, Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models. Endocrinology. 2019 Nov 1;160(11):2673-2691
6*	J:294896 Aryal YP, Lee ES, Kim TY, Sung S, Kim JY, An SY, Jung JK, Ha JH, Suh JY, Yamamoto H, Sohn WJ, Cho SW, Lee Y, An CH, Kim JY, Stage-specific expression patterns of ER stress-related molecules in mice molars: Implications for tooth development. Gene Expr Patterns. 2020 Sep;37:119130
1	J:291194 Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY, An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol. 2019 Nov;234(11):20354-20365
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:157050 Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lovgren-Sandblom A, Bjorkhem I, Edwards PA, Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan;51(1):169-81
1	J:313943 Cao S, Reece EA, Shen WB, Yang P, Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects. Cell Death Dis. 2020 Oct 15;11(10):859
1	J:158314 Firtina Z, Danysh BP, Bai X, Gould DB, Kobayashi T, Duncan MK, Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J Biol Chem. 2009 Dec 18;284(51):35872-84
6*	J:168632 Firtina Z, Duncan MK, Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):135-43
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
6	J:153222 Iwawaki T, Akai R, Yamanaka S, Kohno K, Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
1	J:240829 Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR, Regulation of PERK-eIF2alpha signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nat Commun. 2016 Jul 15;7:12185
1	J:305864 Kalish BT, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME, Huh JR, Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021 Feb;24(2):204-213
1	J:240003 Laguesse S, Creppe C, Nedialkova DD, Prevot PP, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L, A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Dev Cell. 2015 Dec 07;35(5):553-67
2	J:208480 Li X, Xu C, Yang P, c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes. 2013 Feb;62(2):599-608
1	J:253948 Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD, Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol. 2016 Aug;97:1-14
1	J:354587 Nedomova M, Haberecht-Muller S, Moller S, Venz S, Prochazkova M, Prochazka J, Sedlak F, Chawengsaksophak K, Hammer E, Kasparek P, Adamek M, Sedlacek R, Konvalinka J, Kruger E, Grantz Saskova K, DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
2*	J:123644 Roma G, Cobellis G, Claudiani P, Maione F, Cruz P, Tripoli G, Sardiello M, Peluso I, Stupka E, A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Genome Res. 2007 Jul;17(7):1051-60
8	J:308694 Tan YY, Zhang Y, Li B, Ou YW, Xie SJ, Chen PP, Mei SQ, Huang QJ, Zheng LL, Qu LH, PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks. Front Cell Dev Biol. 2021;9:670435
1	J:226104 Wang F, Wu Y, Quon MJ, Li X, Yang P, ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99
1	J:146172 Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK, Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009 Jan 12;184(1):143-58
1	J:132695 Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M, Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One. 2008;3(2):e1611
1	J:353791 Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Alexander LEC, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X, Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
1*	J:270211 Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P, Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282
1*	J:272566 Yang R, Wang H, Kang B, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Xu P, Chang Y, Jia Y, Huang Y, CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
1	J:315123 Zhong J, Xu C, Gabbay-Benziv R, Lin X, Yang P, Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy. Free Radic Biol Med. 2016 Jul;96:234-44