Gene Expression Literature Summary

• Symbol: Six6
• Name: sine oculis-related homeobox 6
• ID: MGI:1341840

56 matching records from 56 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)						1													1
In situ RNA (section)		1		6	1	14	8	1	8	1	10	1	8	7	1	4	3	1	2		1	12
In situ RNA (whole mount)	3	4	4	8		8	2		2					2							2
In situ reporter (knock in)																					1
Northern blot							1
Western blot																					1
RT-PCR			1	1		1	2		3		3		1	3		1	2		3	1		8
cDNA clones							1	1	1				1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Six6  sine oculis-related homeobox 6   (Synonyms: Optx2, Six9)
Results	Reference
3*	J:98077 Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, McInnes RR, Auricchio A, Banfi S, Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005 Apr 1;14(7):913-23
1	J:334460 Bando H, Brinkmeier ML, Castinetti F, Fang Q, Lee MS, Saveanu A, Albarel F, Dupuis C, Brue T, Camper SA, Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023 Jan 13;32(3):367-385
1	J:169150 Bharti K, Gasper M, Bertuzzi S, Arnheiter H, Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development. 2011 Mar;138(5):873-8
13	J:188155 Bharti K, Gasper M, Ou J, Brucato M, Clore-Gronenborn K, Pickel J, Arnheiter H, A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet. 2012 Jul;8(7):e1002757
5*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
4	J:317412 Cheng AH, Fung SW, Hegazi S, Abdalla OHMH, Cheng HM, SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus. Int J Mol Sci. 2021 Dec 26;23(1)
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1*	J:158421 Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL, Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev Biol. 2010;10:4
4*	J:102270 Conte I, Morcillo J, Bovolenta P, Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain. Dev Dyn. 2005 Nov;234(3):718-25
1	J:106771 Davis RJ, Pesah YI, Harding M, Paylor R, Mardon G, Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function. Genesis. 2006 Feb;44(2):84-92
1*	J:121318 Davis SW, Camper SA, Noggin regulates Bmp4 activity during pituitary induction. Dev Biol. 2007 May 1;305(1):145-60
1	J:235514 Davis SW, Mortensen AH, Keisler JL, Zacharias AL, Gage PJ, Yamamura K, Camper SA, beta-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis. BMC Dev Biol. 2016;16(1):16
7*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
2	J:235668 Goldsmith S, Lovell-Badge R, Rizzoti K, SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary. Development. 2016 Jul 1;143(13):2376-88
1	J:223386 Gomez-Marin C, Tena JJ, Acemel RD, Lopez-Mayorga M, Naranjo S, de la Calle-Mustienes E, Maeso I, Beccari L, Aneas I, Vielmas E, Bovolenta P, Nobrega MA, Carvajal J, Gomez-Skarmeta JL, Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7542-7
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:210692 Hagglund AC, Berghard A, Carlsson L, Canonical Wnt/beta-catenin signalling is essential for optic cup formation. PLoS One. 2013;8(12):e81158
2	J:176341 Hagglund AC, Dahl L, Carlsson L, Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. PLoS One. 2011;6(8):e23387
15*	J:56368 Jean D, Bernier G, Gruss P, Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk. Mech Dev. 1999 Jun;84(1-2):31-40
4	J:166952 Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS, Dachshund homologues play a conserved role in islet cell development. Dev Biol. 2010 Dec 15;348(2):143-52
1	J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
1	J:99244 Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL, GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24;308(5730):1927-30
1	J:168233 Larder R, Clark DD, Miller NL, Mellon PL, Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci. 2011 Jan 12;31(2):426-38
2	J:130851 Lavado A, Lagutin OV, Oliver G, Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
6	J:185560 Lee B, Rizzoti K, Kwon DS, Kim SY, Oh S, Epstein DJ, Son Y, Yoon J, Baek K, Jeong Y, Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer. Dev Biol. 2012 Jun 15;366(2):393-403
1	J:200777 Lee B, Song H, Rizzoti K, Son Y, Yoon J, Baek K, Jeong Y, Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain. Dev Biol. 2013 Sep 15;381(2):491-501
5	J:104339 Li X, Perissi V, Liu F, Rose DW, Rosenfeld MG, Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
4	J:246467 Liu W, Cvekl A, Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. Dev Biol. 2017 Aug 01;428(1):164-175
1	J:165328 Liu W, Lagutin O, Swindell E, Jamrich M, Oliver G, Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest. 2010 Oct 1;120(10):3568-77
6*	J:56024 Lopez-Rios J, Gallardo ME, Rodriguez de C rdoba S, Bovolenta P, Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development. Mech Dev. 1999 May;83(1-2):155-9
3*	J:112318 Lord-Grignon J, Abdouh M, Bernier G, Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice. Gene Expr Patterns. 2006 Oct 2;6(8):992-999
1*	J:241394 Mattiske T, Lee K, Gecz J, Friocourt G, Shoubridge C, Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene. Hum Mol Genet. 2016 Dec 15;25(24):5433-5443
3	J:146279 Medina-Martinez O, Amaya-Manzanares F, Liu C, Mendoza M, Shah R, Zhang L, Behringer RR, Mahon KA, Jamrich M, Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary. PLoS One. 2009;4(2):e4513
1	J:218295 Mortensen AH, Schade V, Lamonerie T, Camper SA, Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
6*	J:74240 Mui SH, Hindges R, O'Leary DD, Lemke G, Bertuzzi S, The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
5	J:159508 Nonomura K, Takahashi M, Wakamatsu Y, Takano-Yamamoto T, Osumi N, Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development. J Anat. 2010 Jan;216(1):80-91
1*	J:122509 Raetzman LT, Cai JX, Camper SA, Hes1 is required for pituitary growth and melanotrope specification. Dev Biol. 2007 Apr 15;304(2):455-66
1	J:104523 Ribes V, Wang Z, Dolle P, Niederreither K, Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. 2006 Jan;133(2):351-61
3	J:196967 Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Houart C, Meyer G, Blackshaw S, Tole S, LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. J Neurosci. 2013 Apr 17;33(16):6877-84
2	J:317827 Sawai A, Pfennig S, Bulajic M, Miller A, Khodadadi-Jamayran A, Mazzoni EO, Dasen JS, PRC1 sustains the integrity of neural fate in the absence of PRC2 function. Elife. 2022 Jan 7;11:e72769
3*	J:145164 Soker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hoelter SM, Horsch M, Kallnik M, Kling E, Morth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, Hrabe de Angelis M, Graw J, Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol. 2008 Dec 22;8(1):118
1	J:270543 Tanahashi H, Suzuki T, Deletion of Lrp4 increases the incidence of microphthalmia. Biochem Biophys Res Commun. 2018 Nov 30;506(3):478-484
2*	J:145977 Tetreault N, Champagne MP, Bernier G, The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev Biol. 2009 Mar 15;327(2):541-50
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
7*	J:56025 Toy J, Sundin OH, Expression of the optx2 homeobox gene during mouse development. Mech Dev. 1999 May;83(1-2):183-6
1	J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
6*	J:171421 Vandunk C, Hunter LA, Gray PA, Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:232657 Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL, Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun;29(6):842-55
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*	J:353361 Yu H, Chiang A, Rubinstein M, Low MJ, The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Mol Metab. 2024 Sep;87:101993
2	J:319845 Yu H, Rubinstein M, Low MJ, Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes. Elife. 2022 Jan 19;11:e72883
1	J:306263 Zhang YH, Xu M, Shi X, Sun XL, Mu W, Wu H, Wang J, Li S, Su P, Gong L, He M, Yao M, Wu QF, Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 2021 Apr 17;
1	J:182725 Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ, Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell. 2012 Mar 13;22(3):585-96