Gene Expression Literature Summary

• Symbol: Dazl
• Name: deleted in azoospermia-like
• ID: MGI:1342328

71 matching records from 71 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E7.5	E9.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	P
Immunohistochemistry (section)													5		6	9	5		7	1	4		3	5	11
In situ RNA (section)												1	1	1		1	1			1	1				4
Immunohistochemistry (whole mount)		1		1	1	1	1
In situ RNA (whole mount)													1		1	1
Northern blot															1		1				1			1	1
Western blot	1	1													2	1	3		4						8
RT-PCR			2	1	1		2	1	2	1	1	3	5		5	5	5	1	6		3	1	1	4	21
cDNA clones																									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dazl  deleted in azoospermia-like   (Synonyms: Dazla, Daz-like, Tpx-2, Tpx2)
Results	Reference
1	J:158581 Barrios F, Filipponi D, Pellegrini M, Paronetto MP, Di Siena S, Geremia R, Rossi P, De Felici M, Jannini EA, Dolci S, Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. J Cell Sci. 2010 Mar 15;123(Pt 6):871-80
1*	J:166675 Borgel J, Guibert S, Li Y, Chiba H, Schubeler D, Sasaki H, Forne T, Weber M, Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet. 2010 Dec;42(12):1093-100
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
2	J:229091 Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W, Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63
1*	J:334521 Burnet G, Feng CA, Cheung KMF, Bowles J, Spiller CM, Generation and characterization of a Ddx4-iCre transgenic line for deletion in the germline beginning at genital ridge colonization. Genesis. 2023 Mar;61(1-2):e23511
1	J:316527 Chen HH, Welling M, Bloch DB, Munoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N, DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports. 2014 Nov 11;3(5):892-904
4	J:170300 Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M, Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev. 2011 Apr 1;25(7):755-66
1	J:305337 Chen M, Wang Y, Lin L, Dong F, Wu H, Bao S, Gao F, PRMT7 is involved in regulation of germ cell proliferation during embryonic stage. Biochem Biophys Res Commun. 2020 Dec 17;533(4):938-944
4	J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
4*	J:71989 Dai T, Vera Y, Salido EC, Yen PH, Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. BMC Genomics. 2001;2(1):6
1	J:342617 Dali O, D'Cruz S, Legoff L, Diba Lahmidi M, Heitz C, Merret PE, Kernanec PY, Pakdel F, Smagulova F, Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
4	J:343469 Ding Y, He Z, Sha Y, Kee K, Li L, Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility. Development. 2023 Dec 1;150(23):dev202151
3	J:264399 Fu XF, Yang F, Cheng SF, Feng YN, Li L, Dyce PW, Shen W, Sun XF, The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis. Histochem Cell Biol. 2017 Jul;148(1):61-72
8	J:263627 Fukuda K, Masuda A, Naka T, Suzuki A, Kato Y, Saga Y, Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development. PLoS Genet. 2018 Jun;14(6):e1007436
1	J:265597 Gao X, Ma W, Nie J, Zhang C, Zhang J, Yao G, Han J, Xu J, Hu B, Du Y, Shi Q, Yang Z, Huang X, Zhang Y, A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis. 2015 Jan 22;6:e1610
1	J:204566 Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N, Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
4*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4*	J:207748 He J, Stewart K, Kinnell HL, Anderson RA, Childs AJ, A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice. PLoS One. 2013;8(9):e73996
2	J:307864 Horisawa-Takada Y, Kodera C, Takemoto K, Sakashita A, Horisawa K, Maeda R, Shimada R, Usuki S, Fujimura S, Tani N, Matsuura K, Akiyama T, Suzuki A, Niwa H, Tachibana M, Ohba T, Katabuchi H, Namekawa SH, Araki K, Ishiguro KI, Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nat Commun. 2021 Jun 1;12(1):3184
1	J:250152 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z, Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12;5:12982
3	J:224163 Hu YC, Nicholls PK, Soh YQ, Daniele JR, Junker JP, van Oudenaarden A, Page DC, Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling. PLoS Genet. 2015 Mar;11(3):e1005019
2	J:326085 Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P, Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742
1*	J:288127 Imai A, Hagiwara Y, Niimi Y, Tokumoto T, Saga Y, Suzuki A, Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence. PLoS One. 2020;15(4):e0232047
2*	J:118937 Kaji K, Nichols J, Hendrich B, Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development. 2007 Mar;134(6):1123-32
2	J:282136 Kato Y, Iwamori T, Ninomiya Y, Kohda T, Miyashita J, Sato M, Saga Y, ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. EMBO Rep. 2019 Dec 5;20(12):e48251
7	J:230563 Kato Y, Katsuki T, Kokubo H, Masuda A, Saga Y, Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells. Nat Commun. 2016;7:11272
1	J:219506 Kim S, Gunesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA, PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
4*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
3*	J:104848 Lin Y, Page DC, Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice. Dev Biol. 2005 Dec 15;288(2):309-16
2	J:243570 Liu KH, Sun XF, Feng YZ, Cheng SF, Li B, Li YP, Shen W, Li L, The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicol Appl Pharmacol. 2017 Aug 15;329:9-17
2	J:244859 Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Zhao ZA, Gao Z, Ma H, Duan E, Gao F, Gao S, Yi Z, Li L, BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun. 2017 Jan 27;8:14182
1*	J:112224 Maatouk DM, Kellam LD, Mann MR, Lei H, Li E, Bartolomei MS, Resnick JL, DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development. 2006 Sep;133(17):3411-8
3	J:306136 Manti M, Pui HP, Edstrom S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E, Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. FASEB J. 2020 Nov;34(11):14440-14457
1*	J:309442 Mayere C, Neirijnck Y, Sararols P, Rands CM, Stevant I, Kuhne F, Chassot AA, Chaboissier MC, Dermitzakis ET, Nef S, Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination. FASEB J. 2021 Apr;35(4):e21452
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
1	J:214809 Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B, Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
1*	J:307963 Mrowiec K, Chadalski M, Paszek A, Vydra N, Janus P, Pietrowska M, Toma-Jonik A, Gramatyka M, Widlak W, The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Biochim Biophys Acta Mol Cell Res. 2021 Sep;1868(10):119086
3*	J:64334 Nadler JJ, Braun RE, Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells [letter]. Genesis. 2000 Jul;27(3):117-23
2	J:285778 Nagaoka SI, Nakaki F, Miyauchi H, Nosaka Y, Ohta H, Yabuta Y, Kurimoto K, Hayashi K, Nakamura T, Yamamoto T, Saitou M, ZGLP1 is a determinant for the oogenic fate in mice. Science. 2020 Mar 6;367(6482)
1	J:184976 Narboux-Neme N, Goiame R, Mattei MG, Cohen-Tannoudji M, Wassef M, Integration of H-2Z1, a Somatosensory Cortex-Expressed Transgene, Interferes with the Expression of the Satb1 and Tbc1d5 Flanking Genes and Affects the Differentiation of a Subset of Cortical Interneurons. J Neurosci. 2012 May 23;32(21):7287-7300
1	J:282807 Nicholls PK, Schorle H, Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC, Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687
4*	J:87821 Olesen C, Moller M, Byskov AG, Tesmin transcription is regulated differently during male and female meiosis. Mol Reprod Dev. 2004 Jan;67(1):116-26
1*	J:126326 Olive V, Wagner N, Chan S, Kastner P, Vannetti C, Cuzin F, Rassoulzadegan M, PU.1 (Sfpi1), a pleiotropic regulator expressed from the first embryonic stages with a crucial function in germinal progenitors. Development. 2007 Nov;134(21):3815-25
5*	J:136904 Pan HA, Liao RW, Chung CL, Teng YN, Lin YM, Kuo PL, DAZL protein expression in mouse preimplantation embryo. Fertil Steril. 2008 May;89(5 Suppl):1324-7
1	J:110210 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A, Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8090-5
1*	J:326689 Phan TP, Boatwright CA, Drown CG, Skinner MW, Strong MA, Jordan PW, Holland AJ, Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells. Genes Dev. 2022 Jun 1;36(11-12):718-736
2	J:324159 Qin J, Huang T, Wang J, Xu L, Dang Q, Xu X, Liu H, Liu Z, Shao C, Zhang X, RAD51 is essential for spermatogenesis and male fertility in mice. Cell Death Discov. 2022 Mar 15;8(1):118
2	J:194978 Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR, The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013 May 1;22(9):1791-806
4*	J:42612 Ruggiu M, Speed R, Taggart M, McKay SJ, Kilanowski F, Saunders P , Dorin J , Cooke HJ, The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. Nature. 1997 Sep 4;389(6646):73-7
1	J:126330 Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S, Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007 Sep 20;449(7160):346-50
6*	J:47337 Seligman J, Page DC, The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation. Biochem Biophys Res Commun. 1998 Apr 28;245(3):878-82
2	J:342011 Shimada R, Kato Y, Takeda N, Fujimura S, Yasunaga KI, Usuki S, Niwa H, Araki K, Ishiguro KI, STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells. Nat Commun. 2023 Oct 25;14(1):6443
1*	J:278327 Snider PL, Snider E, Simmons O, Lilly B, Conway SJ, Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22;6(2)
1	J:228910 Soh YQ, Junker JP, Gill ME, Mueller JL, van Oudenaarden A, Page DC, A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary. PLoS Genet. 2015 Sep;11(9):e1005531
2*	J:242348 Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC, Meioc maintains an extended meiotic prophase I in mice. PLoS Genet. 2017 Apr;13(4):e1006704
4	J:306228 Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF, Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction. 2012 May;143(5):611-24
1*	J:180844 Strauss TJ, Castrillon DH, Hammes SR, GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis. Reproduction. 2011 Feb;141(2):173-81
4	J:217384 Suzuki A, Niimi Y, Saga Y, Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3(12):1207-16
5	J:230058 Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y, Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016 Jan;17(1):37-46
1	J:187029 Suzuki A, Saba R, Miyoshi K, Morita Y, Saga Y, Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. PLoS One. 2012;7(3):e33558
1	J:345877 Suzuki A, Uranishi K, Nishimoto M, Mizuno Y, Mizuno S, Takahashi S, Eisenman RN, Okuda A, MAX controls meiotic entry in sexually undifferentiated germ cells. Sci Rep. 2024 Mar 4;14(1):5236
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5	J:316493 Wang Q, Liu X, Tang N, Archambeault DR, Li J, Song H, Tang C, He B, Matzuk MM, Wang Y, GASZ promotes germ cell derivation from embryonic stem cells. Stem Cell Res. 2013 Sep;11(2):845-60
2	J:277545 Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015 Apr;92(4):104
1*	J:296647 Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB, DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. J Am Soc Nephrol. 2019 Jan;30(1):63-78
1	J:301042 Wright D, Kiso M, Saga Y, Genetic and structural analysis of the in vivo functional redundancy between murine NANOS2 and NANOS3. Development. 2021 Jan 11;148(1):dev191916
2	J:353355 Yao X, Wang C, Yu W, Sun L, Lv Z, Xie X, Tian S, Yan L, Li L, Liu J, BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
4	J:328457 Yin H, Suye S, Zhou Z, Cai H, Fu C, The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice. Reproduction. 2022 Sep 1;164(3):71-82
1	J:324155 Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L, BCAS2 is involved in alternative splicing and mouse oocyte development. FASEB J. 2022 Feb;36(2):e22128
2	J:270801 Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I, Esrrb Complementation Rescues Development of Nanog-Null Germ Cells. Cell Rep. 2018 Jan 9;22(2):332-339
2	J:266305 Zhou Y, Qin Y, Qin Y, Xu B, Guo T, Ke H, Chen M, Zhang L, Han F, Li Y, Chen M, Behrens A, Wang Y, Xu Z, Chen ZJ, Gao F, Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans. PLoS Genet. 2018 Aug;14(8):e1007463