Gene Expression Literature Summary

• Symbol: Klf1
• Name: Kruppel-like transcription factor 1 (erythroid)
• ID: MGI:1342771

42 matching records from 42 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E	P
In situ RNA (section)				1			1			1						1							1
Immunohistochemistry (whole mount)										1				1
In situ RNA (whole mount)					1		1	1		1		1						1
In situ reporter (knock in)										1				1									1
Northern blot			1							2	1	1				3	1	1		1			2
Western blot								1	1	2					2	5							2
RT-PCR	1	1				2		5	2	4		3	2	7	1	4	1	1	2		2	3	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Klf1  Kruppel-like transcription factor 1 (erythroid)   (Synonyms: Eklf, Nan)
Results	Reference
1*	J:278470 Acharya D, Nera B, Milstone ZJ, Bourke L, Yoon Y, Rivera-Perez JA, Trivedi CM, Fazzio TG, TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis. Sci Rep. 2018 Oct 8;8(1):14908
2*	J:175394 Alhashem YN, Vinjamur DS, Basu M, Klingmuller U, Gaensler KM, Lloyd JA, Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem. 2011 Jul 15;286(28):24819-27
5*	J:29401 Anderson KP, Kern CB, Crable SC, Lingrel JB, Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol. 1995 Nov;15(11):5957-65
3*	J:94507 Asano H, Murate T, Naoe T, Saito H, Stamatoyannopoulos G, Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif. Biochem J. 2004 Dec 15;384(Pt 3):647-53
1*	J:274331 Cantu I, van de Werken HJG, Gillemans N, Stadhouders R, Heshusius S, Maas A, Esteghamat F, Ozgur Z, van IJcken WFJ, Grosveld F, von Lindern M, Philipsen S, van Dijk TB, The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation. PLoS One. 2019;14(3):e0208659
1	J:345820 Cardarelli S, Biglietto M, Orsini T, Fustaino V, Monaco L, de Oliveira do Rego AG, Liccardo F, Masciarelli S, Fazi F, Naro F, De Angelis L, Pellegrini M, Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169
5	J:148823 Corrigan PM, Dobbin E, Freeburn RW, Wheadon H, Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev. 2009 Jun;18(5):759-72
2*	J:75937 Damert A, Miquerol L, Gertsenstein M, Risau W, Nagy A, Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development. 2002 Apr;129(8):1881-92
1*	J:224837 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP, Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
1	J:89444 Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M, The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
1	J:235912 Ghanem LR, Kromer A, Silverman IM, Chatterji P, Traxler E, Penzo-Mendez A, Weiss MJ, Stanger BZ, Liebhaber SA, The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Mol Cell Biol. 2015 Nov 02;36(2):304-19
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:271614 Gudmundsdottir B, Gudmundsson KO, Klarmann KD, Singh SK, Sun L, Singh S, Du Y, Coppola V, Stockwin L, Nguyen N, Tessarollo L, Thorsteinsson L, Sigurjonsson OE, Gudmundsson S, Rafnar T, Tisdale JF, Keller JR, POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248
1	J:241569 Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y, Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017 May 15;144(10):1906-1917
2	J:310414 Hung CH, Lee TL, Huang AY, Yang KC, Shyu YC, Wen SC, Lu MJ, Yuan S, Shen CJ, A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis. Int J Mol Sci. 2021 Jul 27;22(15)
1	J:306881 Hung CH, Wang KY, Liou YH, Wang JP, Huang AY, Lee TL, Jiang ST, Liao NS, Shyu YC, Shen CJ, Negative Regulation of the Differentiation of Flk2(-) CD34(-) LSK Hematopoietic Stem Cells by EKLF/KLF1. Int J Mol Sci. 2020 Nov 10;21(22):8448
1*	J:69831 Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y, Nagata S, Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science. 2001 May 25;292(5521):1546-9
1*	J:35594 Kieran MW, Perkins AC, Orkin SH, Zon LI, Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9126-31
3*	J:181881 Lee JS, Ward WO, Knapp G, Ren H, Vallanat B, Abbott B, Ho K, Karp SJ, Corton JC, Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33
2	J:153993 Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J, Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor. Mol Cell Biol. 2009 Nov;29(21):5900-10
1*	J:31156 Lin CS, Lim SK, D'Agati V, Costantini F, Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
2	J:228214 Lohmann F, Dangeti M, Soni S, Chen X, Planutis A, Baron MH, Choi K, Bieker JJ, The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Mol Cell Biol. 2015 Nov;35(21):3726-38
1	J:287326 Malik N, Dunn KM, Cassels J, Hay J, Estell C, Sansom OJ, Michie AM, mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Sci Rep. 2019 Nov 15;9(1):16917
1*	J:136836 Noordermeer D, Branco MR, Splinter E, Klous P, van Ijcken W, Swagemakers S, Koutsourakis M, van der Spek P, Pombo A, de Laat W, Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region. PLoS Genet. 2008 Mar;4(3):e1000016
3	J:25650 Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F, Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995 May 25;375(6529):316-8
1	J:224103 Papadopoulos P, Gutierrez L, Demmers J, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L, TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis. Mol Cell Biol. 2015 Jun;35(12):2103-18
3	J:47299 Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN, Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95
1	J:25651 Perkins AC, Sharpe AH, Orkin SH, Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
1	J:175864 Porcu S, Manchinu MF, Marongiu MF, Sogos V, Poddie D, Asunis I, Porcu L, Marini MG, Moi P, Cao A, Grosveld F, Ristaldi MS, Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis. Mol Cell Biol. 2011 Oct;31(19):4144-54
4	J:136561 Quadrini KJ, Gruzglin E, Bieker JJ, Non-random subcellular distribution of variant EKLF in erythroid cells. Exp Cell Res. 2008 Apr 15;314(7):1595-604
1	J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
2	J:122680 Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M, GATA-1 self-association controls erythroid development in vivo. J Biol Chem. 2007 May 25;282(21):15862-71
4*	J:118858 Shyu YC, Lee TL, Wen SC, Chen H, Hsiao WY, Chen X, Hwang J, Shen CK, Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription. Mol Cell Biol. 2007 Mar;27(6):2309-23
2	J:163685 Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL, Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15151-6
12	J:33704 Southwood CM, Downs KM, Bieker JJ, Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn. 1996 Jul;206(3):248-59
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2*	J:47376 Tewari R, Gillemans N, Wijgerde M, Nuez B, von Lindern M, Grosveld F, Philipsen S, Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. EMBO J. 1998 Apr 15;17(8):2334-41
1*	J:285404 Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y, Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver. Stem Cell Reports. 2019 Dec 10;13(6):992-1005
1	J:56429 Vannucchi AM, Linari S, Lin CS, Koury MJ, Bondurant MC, Migliaccio AR, Increased expression of the distal, but not of the proximal, Gata1 transcripts during differentiation of primary erythroid cells. J Cell Physiol. 1999 Sep;180(3):390-401
1*	J:51402 Wani MA, Means RT Jr, Lingrel JB, Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 1998 Jul;7(4):229-38
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*	J:238253 Zhang M, Zhu X, Zhang Y, Cai Y, Chen J, Sivaprakasam S, Gurav A, Pi W, Makala L, Wu J, Pace B, Tuan-Lo D, Ganapathy V, Singh N, Li H, RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. Cell Death Differ. 2015 Dec;22(12):1922-34