Gene Expression Literature Summary

• Symbol: Dand5
• Name: DAN domain family member 5, BMP antagonist
• ID: MGI:1344365

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E8.5	E10.5	E12.5	E14.5	E
Immunohistochemistry (section)		1	1
In situ RNA (section)		2	4
Immunohistochemistry (whole mount)			1
In situ RNA (whole mount)	2	9	31	3				3
In situ reporter (knock in)		1	1
RT-PCR			1		1	1	1
cDNA clones				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dand5  DAN domain family member 5, BMP antagonist   (Synonyms: Cerl-2, Cerl2, Cerr2, coco, Dte, GREM3)
Results	Reference
1	J:182741 Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A, Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. 2012 Apr;139(7):1276-84
1	J:213344 Barratt KS, Glanville-Jones HC, Arkell RM, The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis. 2014 Jun;52(6):626-35
2	J:222988 Beckers A, Alten L, Viebahn C, Andre P, Gossler A, The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15765-70
1*	J:200709 Botilde Y, Yoshiba S, Shinohara K, Hasegawa T, Nishimura H, Shiratori H, Hamada H, Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 2013 Sep 1;381(1):203-12
3*	J:283946 Chatterjee S, Nandakumar P, Auer DR, Gabriel SB, Chakravarti A, Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Proc Natl Acad Sci U S A. 2019 Dec 9;
1	J:261380 Concepcion D, Hamada H, Papaioannou VE, Tbx6 controls left-right asymmetry through regulation of Gdf1. Biol Open. 2018 May 4;7(5):bio032565
1*	J:213591 Concepcion D, Papaioannou VE, Nature and extent of left/right axis defects in T(Wis) /T(Wis) mutant mouse embryos. Dev Dyn. 2014 Aug;243(8):1046-53
2*	J:268103 Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen CM, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S, A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Sci Rep. 2018 Jul 11;8(1):10439
1	J:170490 Field S, Riley KL, Grimes DT, Hilton H, Simon M, Powles-Glover N, Siggers P, Bogani D, Greenfield A, Norris DP, Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development. 2011 Mar;138(6):1131-42
1*	J:79391 Fujiwara T, Dehart DB, Sulik KK, Hogan BL, Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. Development. 2002 Oct;129(20):4685-96
1	J:214665 Fuller K, O'Connell JT, Gordon J, Mauti O, Eggenschwiler J, Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014 Jul 15;391(2):182-95
1	J:220709 Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, Arnold SJ, Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells. EMBO J. 2015 Apr 15;34(8):1078-89
2	J:140928 Furtado MB, Solloway MJ, Jones VJ, Costa MW, Biben C, Wolstein O, Preis JI, Sparrow DB, Saga Y, Dunwoodie SL, Robertson EJ, Tam PP, Harvey RP, BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 2008 Nov 1;22(21):3037-49
1	J:233311 Grimes DT, Keynton JL, Buenavista MT, Jin X, Patel SH, Kyosuke S, Vibert J, Williams DJ, Hamada H, Hussain R, Nauli SM, Norris DP, Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination. PLoS Genet. 2016 Jun;12(6):e1006070
2	J:316131 Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK, Zhang Q, Thompson J, Lucas JS, Bingle CD, Norris DP, Roy S, Brown A, De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell. 2021 Nov 11;184(23):5791-5806.e19
5	J:199895 Inacio JM, Marques S, Nakamura T, Shinohara K, Meno C, Hamada H, Belo JA, The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node. PLoS One. 2013;8(3):e60406
1*	J:142123 Ishimura A, Chida S, Osada S, Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Dev Dyn. 2008 Dec;237(12):3565-76
2	J:173964 Kawasumi A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Belo JA, Shiratori H, Hamada H, Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. Dev Biol. 2011 May 15;353(2):321-30
1*	J:162627 Kinzel D, Boldt K, Davis EE, Burtscher I, Trumbach D, Diplas B, Attie-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H, Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77
2*	J:199577 Kitajima K, Oki S, Ohkawa Y, Sumi T, Meno C, Wnt signaling regulates left-right axis formation in the node of mouse embryos. Dev Biol. 2013 Aug 15;380(2):222-32
1	J:142430 Kumar A, Lualdi M, Lewandoski M, Kuehn MR, Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn. 2008 Dec;237(12):3591-601
2*	J:185804 Larkins CE, Long AB, Caspary T, Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev Biol. 2012 Jul 1;367(1):15-24
3*	J:168841 Lopes Floro K, Artap ST, Preis JI, Fatkin D, Chapman G, Furtado MB, Harvey RP, Hamada H, Sparrow DB, Dunwoodie SL, Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet. 2011 Mar 15;20(6):1097-110
6*	J:93051 Marques S, Borges AC, Silva AC, Freitas S, Cordenonsi M, Belo JA, The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 2004 Oct 1;18(19):2342-7
2	J:307831 Minegishi K, Rothe B, Komatsu KR, Ono H, Ikawa Y, Nishimura H, Katoh TA, Kajikawa E, Sai X, Miyashita E, Takaoka K, Bando K, Kiyonari H, Yamamoto T, Saito H, Constam DB, Hamada H, Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. Nat Commun. 2021 Jul 1;12(1):4071
1	J:313293 Mizuno K, Shiozawa K, Katoh TA, Minegishi K, Ide T, Ikawa Y, Nishimura H, Takaoka K, Itabashi T, Iwane AH, Nakai J, Shiratori H, Hamada H, Role of Ca(2+) transients at the node of the mouse embryo in breaking of left-right symmetry. Sci Adv. 2020 Jul;6(30):eaba1195
1	J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
3	J:193411 Nakamura T, Saito D, Kawasumi A, Shinohara K, Asai Y, Takaoka K, Dong F, Takamatsu A, Belo JA, Mochizuki A, Hamada H, Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nat Commun. 2012;3:1322
2	J:154981 Oki S, Kitajima K, Marques S, Belo JA, Yokoyama T, Hamada H, Meno C, Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos. Development. 2009 Dec;136(23):3917-25
3*	J:54640 Pearce JJ, Penny G, Rossant J, A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
1	J:185535 Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, Saijoh Y, Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012 Jul;139(13):2426-35
1*	J:286656 Shylo NA, Emmanouil E, Ramrattan D, Weatherbee SD, Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice. Dev Biol. 2020 Apr 15;460(2):187-199
1*	J:253966 Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF, Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 Dec 18;43(6):744-762.e11
1	J:245906 Sugrue KF, Zohn IE, Mechanism for generation of left isomerism in Ccdc40 mutant embryos. PLoS One. 2017;12(2):e0171180
1*	J:252050 Sung YH, Baek IJ, Kim YH, Gho YS, Oh SP, Lee YJ, Lee HW, PIERCE1 is critical for specification of left-right asymmetry in mice. Sci Rep. 2016 Jun 16;6:27932
1	J:248235 Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG, Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):846-51
1	J:184721 Viotti M, Niu L, Shi SH, Hadjantonakis AK, Role of the gut endoderm in relaying left-right patterning in mice. PLoS Biol. 2012 Mar;10(3):e1001276
1*	J:187958 Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H, Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012 Oct 12;338(6104):226-31