Gene Expression Literature Summary

• Symbol: Vax2
• Name: ventral anterior homeobox 2
• ID: MGI:1346018

63 matching records from 63 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)				3		1	1	2			2	1	1	2				1
In situ RNA (section)		5		10	1	6	1	14	6		4	1		2	1	1	1	7
Immunohistochemistry (whole mount)			1					1
In situ RNA (whole mount)	4	4	1	10		7				1
Western blot			1	1				1			1		1	1				1
RT-PCR						1		1			1			1				5
cDNA clones					1													1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Vax2  ventral anterior homeobox 2
Results	Reference
1*	J:98077 Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, McInnes RR, Auricchio A, Banfi S, Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005 Apr 1;14(7):913-23
1	J:273860 Andreu-Cervera A, Anselme I, Karam A, Laclef C, Catala M, Schneider-Maunoury S, The Ciliopathy Gene Ftm/Rpgrip1l Controls Mouse Forebrain Patterning via Region-Specific Modulation of Hedgehog/Gli Signaling. J Neurosci. 2019 Mar 27;39(13):2398-2415
1	J:218165 Bankhead EJ, Colasanto MP, Dyorich KM, Jamrich M, Murtaugh LC, Fuhrmann S, Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015 Jan;185(1):197-213
1*	J:74241 Barbieri AM, Broccoli V, Bovolenta P, Alfano G, Marchitiello A, Mocchetti C, Crippa L, Bulfone A, Marigo V, Ballabio A, Banfi S, Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development. 2002 Feb;129(3):805-13
5*	J:57663 Barbieri AM, Lupo G, Bulfone A, Andreazzoli M, Mariani M, Fougerousse F, Consalez GG, Borsani G, Beckmann JS, Barsacchi G, Ballabio A, Banfi S, A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10729-34
1*	J:78684 Baumer N, Marquardt T, Stoykova A, Ashery-Padan R, Chowdhury K, Gruss P, Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development. 2002 Oct;129(19):4535-45
1	J:120113 Behesti H, Holt JK, Sowden JC, The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup. BMC Dev Biol. 2006;6:62
1*	J:152494 Behesti H, Papaioannou VE, Sowden JC, Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol. 2009 Sep 15;333(2):360-72
1	J:188155 Bharti K, Gasper M, Ou J, Brucato M, Clore-Gronenborn K, Pickel J, Arnheiter H, A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet. 2012 Jul;8(7):e1002757
2	J:331141 Boobalan E, Thompson AH, Alur RP, McGaughey DM, Dong L, Shih G, Vieta-Ferrer ER, Onojafe IF, Kalaskar VK, Arno G, Lotery AJ, Guan B, Bender C, Memon O, Brinster L, Soleilhavoup C, Panman L, Badea TC, Minella A, Lopez AJ, Thomasy SM, Moshiri A, Blain D, Hufnagel RB, Cogliati T, Bharti K, Brooks BP, Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure. Invest Ophthalmol Vis Sci. 2022 Nov 1;63(12):5
1	J:303632 Bosze B, Suarez-Navarro J, Soofi A, Lauderdale JD, Dressler GR, Brown NL, Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021 Apr;472:18-29
4*	J:51411 Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E, Borsani G, Banfi S, Ballabio A, The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function. Hum Mol Genet. 1998 Dec;7(13):1997-2006
1	J:249800 Burnett JB, Lupu FI, Eggenschwiler JT, Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017 Oct 1;430(1):32-40
1*	J:136314 Burns CJ, Zhang J, Brown EC, Van Bibber AM, Van Es J, Clevers H, Ishikawa TO, Taketo MM, Vetter ML, Fuhrmann S, Investigation of Frizzled-5 during embryonic neural development in mouse. Dev Dyn. 2008 Jun;237(6):1614-26
1	J:198655 Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X, Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul;140(13):2711-23
1	J:83530 Dakubo GD, Wang YP, Mazerolle C, Campsall K, McMahon AP, Wallace VA, Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development. 2003 Jul;130(13):2967-80
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:290813 Fiore L, Takata N, Acosta S, Ma W, Pandit T, Oxendine M, Oliver G, Optic vesicle morphogenesis requires primary cilia. Dev Biol. 2020 Jun 15;462(2):119-128
1*	J:199602 Fotaki V, Smith R, Pratt T, Price DJ, Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/beta-catenin signalling in the developing nasal retina of the mouse. Dev Biol. 2013 Aug 15;380(2):299-313
1	J:153566 Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z, Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol. 2009 Oct 1;334(1):31-45
1	J:106158 Furimsky M, Wallace VA, Complementary Gli activity mediates early patterning of the mouse visual system. Dev Dyn. 2006 Mar;235(3):594-605
3	J:210692 Hagglund AC, Berghard A, Carlsson L, Canonical Wnt/beta-catenin signalling is essential for optic cup formation. PLoS One. 2013;8(12):e81158
3	J:237526 Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y, Emergence of dorsal-ventral polarity in ESC-derived retinal tissue. Development. 2016 Nov 01;143(21):3895-3906
1	J:226834 Jones I, Hagglund AC, Tornqvist G, Nord C, Ahlgren U, Carlsson L, A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015 Dec 1;8(12):1517-29
1	J:99244 Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL, GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24;308(5730):1927-30
14	J:113403 Kim JW, Lemke G, Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 2006 Oct 15;20(20):2833-47
1*	J:158502 Kumar S, Duester G, Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2. Dev Biol. 2010 Apr 1;340(1):67-74
1	J:183997 Langer L, Taranova O, Sulik K, Pevny L, SOX2 hypomorphism disrupts development of the prechordal floor and optic cup. Mech Dev. 2012 Mar;129(1-4):1-12
3*	J:70735 Lee CS, May NR, Fan CM, Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol. 2001 Aug 1;236(1):17-29
2	J:173635 Lieven O, Ruther U, The Dkk1 dose is critical for eye development. Dev Biol. 2011 Jul 1;355(1):124-37
1	J:143446 Liu C, Nathans J, An essential role for frizzled 5 in mammalian ocular development. Development. 2008 Nov;135(21):3567-76
1	J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
1	J:165328 Liu W, Lagutin O, Swindell E, Jamrich M, Oliver G, Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest. 2010 Oct 1;120(10):3568-77
1	J:239790 Marcos S, Gonzalez-Lazaro M, Beccari L, Carramolino L, Martin-Bermejo MJ, Amarie O, Mateos-San Martin D, Torroja C, Bogdanovic O, Doohan R, Puk O, Hrabe de Angelis M, Graw J, Gomez-Skarmeta JL, Casares F, Torres M, Bovolenta P, Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015 Sep 01;142(17):3009-20
1	J:102847 Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB, Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 2005 Nov;132(21):4789-800
2	J:138405 Matt N, Ghyselinck NB, Pellerin I, Dupe V, Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis. Dev Biol. 2008 Aug 1;320(1):140-8
2	J:294016 Medina-Martinez O, Haller M, Rosenfeld JA, O'Neill MA, Lamb DJ, Jamrich M, The transcription factor Maz is essential for normal eye development. Dis Model Mech. 2020 Aug 18;13(8):dmm044412
5*	J:316715 Meola N, Pizzo M, Alfano G, Surace EM, Banfi S, The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina. RNA. 2012 Jan;18(1):111-23
2	J:333797 Min KW, Kim N, Lee JH, Sung Y, Kim M, Lee EJ, Kim JM, Kim JH, Lee J, Cho W, Yang JM, Kim N, Kim J, Lee CJ, Park YG, Lee SH, Lee HW, Kim JW, Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant. Exp Mol Med. 2023 Feb;55(2):385-400
1	J:108515 Molotkov A, Molotkova N, Duester G, Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. Development. 2006 May;133(10):1901-10
2	J:119026 Morcillo J, Martinez-Morales JR, Trousse F, Fermin Y, Sowden JC, Bovolenta P, Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006 Aug;133(16):3179-90
5*	J:74240 Mui SH, Hindges R, O'Leary DD, Lemke G, Bertuzzi S, The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
1	J:98488 Mui SH, Kim JW, Lemke G, Bertuzzi S, Vax genes ventralize the embryonic eye. Genes Dev. 2005 May 15;19(10):1249-59
1	J:171526 Murali D, Kawaguchi-Niida M, Deng CX, Furuta Y, Smad4 Is Required Predominantly in the Developmental Processes Dependent on the BMP Branch of the TGF-{beta} Signaling System in the Embryonic Mouse Retina. Invest Ophthalmol Vis Sci. 2011;52(6):2930-7
1	J:240082 Noh H, Lee H, Park E, Park S, Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016 Feb 01;143(3):461-72
1	J:355222 Nord C, Jones I, Garcia-Maestre M, Hagglund AC, Carlsson L, Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn. 2024 Oct;253(10):922-939
1	J:181398 Ogata-Iwao M, Inatani M, Iwao K, Takihara Y, Nakaishi-Fukuchi Y, Irie F, Sato S, Furukawa T, Yamaguchi Y, Tanihara H, Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6671-9
6*	J:328043 Ohsaki K, Morimitsu T, Ishida Y, Kominami R, Takahashi N, Expression of the Vax family homeobox genes suggests multiple roles in eye development. Genes Cells. 1999 May;4(5):267-76
1	J:164377 Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ, Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62
1	J:160165 Pinter R, Hindges R, Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm. PLoS One. 2010;5(4):e10021
2	J:95023 Sakai Y, Luo T, McCaffery P, Hamada H, Drager UC, CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development. Dev Biol. 2004 Dec 1;276(1):143-57
3*	J:58564 Schulte D, Furukawa T, Peters MA, Kozak CA, Cepko CL, Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron. 1999 Nov;24(3):541-53
1	J:157924 Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ, COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar;137(5):725-34
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:176253 Vacik T, Stubbs JL, Lemke G, A novel mechanism for the transcriptional regulation of Wnt signaling in development. Genes Dev. 2011 Sep 1;25(17):1783-95
1	J:276573 Wiegering A, Petzsch P, Kohrer K, Ruther U, Gerhardt C, GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis. Dev Biol. 2019 Jun 15;450(2):141-154
1*	J:327588 Yamada R, Oguri A, Fujiki K, Shirahige K, Takezoe H, Takahashi N, Kanai Y, Single-cell transcriptional analysis reveals developmental stage-dependent changes in retinal progenitors in the murine early optic vesicle. Biochem Biophys Res Commun. 2021 Mar 5;543:80-86
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2	J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
1	J:197830 Zhang R, Huang H, Cao P, Wang Z, Chen Y, Pan Y, Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85
1	J:156965 Zhang W, Mulieri PJ, Gaio U, Bae GU, Krauss RS, Kang JS, Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. FEBS J. 2009 Oct;276(20):5998-6010
4*	J:156737 Zhao L, Saitsu H, Sun X, Shiota K, Ishibashi M, Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mech Dev. 2010 January - February;127(1-2):62-72
1*	J:143210 Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ, Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. Dev Dyn. 2008 Dec;237(12):3681-9