Gene Expression Literature Summary

• Symbol: Slc26a4
• Name: solute carrier family 26, member 4
• ID: MGI:1346029

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)		1	1		1	1	3	1	2		4	1	1	1	2		13
In situ RNA (section)				1			2	2	2	1	2	1	1	3	1		5
Immunohistochemistry (whole mount)			1		1		1		1								1
In situ RNA (whole mount)	1															1
Western blot					1		1		1		1	1		1			2
RT-PCR			1	1	2		2	1	1		2	3	1	1			10
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Slc26a4  solute carrier family 26, member 4   (Synonyms: Pds, pendrin)
Results	Reference
1	J:214677 Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A, Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. Dev Biol. 2014 Jul 1;391(1):54-65
1	J:92326 Burton Q, Cole LK, Mulheisen M, Chang W, Wu DK, The role of Pax2 in mouse inner ear development. Dev Biol. 2004 Aug 1;272(1):161-75
1	J:197347 Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, Hubner CA, Eladari D, Renal intercalated cells are rather energized by a proton than a sodium pump. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7928-33
2	J:104329 Choo D, Ward J, Reece A, Dou H, Lin Z, Greinwald J, Molecular mechanisms underlying inner ear patterning defects in kreisler mutants. Dev Biol. 2006 Jan 15;289(2):308-17
2	J:215675 Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L, LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea. J Neurosci. 2014 Jul 23;34(30):10072-7
1	J:270523 Desgrange A, Heliot C, Skovorodkin I, Akram SU, Heikkila J, Ronkainen VP, Miinalainen I, Vainio SJ, Cereghini S, HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Development. 2017 Dec 15;144(24):4704-4719
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
7*	J:57104 Everett LA, Morsli H, Wu DK, Green ED, Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9727-32
2	J:355097 Gao C, Chen L, Chen E, Tsilosani A, Xia Y, Zhang W, Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells. J Am Soc Nephrol. 2021 Dec 1;32(12):3035-3049
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:316110 Guo Q, Wang Y, Tripathi P, Manda KR, Mukherjee M, Chaklader M, Austin PF, Surendran K, Chen F, Adam10 mediates the choice between principal cells and intercalated cells in the kidney. J Am Soc Nephrol. 2015 Jan;26(1):149-59
1	J:292950 Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM, GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2018 Mar;29(3):857-868
6	J:249431 Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ, Molecular architecture underlying fluid absorption by the developing inner ear. Elife. 2017 Oct 10;6:e26851
1*	J:284778 Huebner AK, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J, Hubner CA, Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice. J Assoc Res Otolaryngol. 2019 Jun;20(3):233-245
1	J:82307 Hulander M, Kiernan AE, Blomqvist SR, Carlsson P, Samuelsson EJ, Johansson BR, Steel KP, Enerback S, Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development. 2003 May;130(9):2013-25
1	J:154589 Jeong HW, Jeon US, Koo BK, Kim WY, Im SK, Shin J, Cho Y, Kim J, Kong YY, Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009 Nov;119(11):3290-300
11*	J:150394 Jouret F, Auzanneau C, Debaix H, Wada GH, Pretto C, Marbaix E, Karet FE, Courtoy PJ, Devuyst O, Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005 Nov;16(11):3235-46
1	J:352715 Kang HS, Grimm SA, Liao XH, Jetten AM, GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65
13	J:171693 Kim HM, Wangemann P, Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. PLoS One. 2011;6(3):e17949
7	J:285979 Kim MA, Kim SH, Ryu N, Ma JH, Kim YR, Jung J, Hsu CJ, Choi JY, Lee KY, Wangemann P, Bok J, Kim UK, Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing. Theranostics. 2019;9(24):7184-7199
5	J:199292 Li X, Sanneman JD, Harbidge DG, Zhou F, Ito T, Nelson R, Picard N, Chambrey R, Eladari D, Miesner T, Griffith AJ, Marcus DC, Wangemann P, SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice. PLoS Genet. 2013 Jul;9(7):e1003641
1	J:301112 Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV, Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
1	J:85609 Merves M, Krane CM, Dou H, Greinwald JH, Menon AG, Choo D, Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant. J Assoc Res Otolaryngol. 2003 Jun;4(2):264-75
2	J:205283 Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M, Programmed cell senescence during mammalian embryonic development. Cell. 2013 Nov 21;155(5):1104-18
1*	J:188593 Norgett EE, Golder ZJ, Lorente-Canovas B, Ingham N, Steel KP, Frankl FE, Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13775-80
3	J:212428 Raft S, Andrade LR, Shao D, Akiyama H, Henkemeyer M, Wu DK, Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014 Jun 1;390(1):51-67
5	J:129782 Song HK, Kim WY, Lee HW, Park EY, Han KH, Nielsen S, Madsen KM, Kim J, Origin and fate of pendrin-positive intercalated cells in developing mouse kidney. J Am Soc Nephrol. 2007 Oct;18(10):2672-82
2	J:332093 Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH, Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH, Lovell-Badge R, Cheah KSE, SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119
1*	J:281403 Trepiccione F, Soukaseum C, Iervolino A, Petrillo F, Zacchia M, Schutz G, Eladari D, Capasso G, Hadchouel J, A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F901-F906
1	J:160473 Trowe MO, Shah S, Petry M, Airik R, Schuster-Gossler K, Kist R, Kispert A, Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse. Dev Biol. 2010 Jun 1;342(1):51-62
1	J:221167 Urness LD, Wang X, Shibata S, Ohyama T, Mansour SL, Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015 Apr 1;400(1):59-71
1	J:249938 Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J, Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017 Jun 3;6:e24265
2*	J:193048 Wu L, Sagong B, Choi JY, Kim UK, Bok J, A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
2	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
4	J:119674 Yamaguchi Y, Yonemura S, Takada S, Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006 Dec;133(23):4737-48