Gene Expression Literature Summary

• Symbol: Hs2st1
• Name: heparan sulfate 2-O-sulfotransferase 1
• ID: MGI:1346049

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E18.5	E	P
Immunohistochemistry (section)									1			1	1
In situ RNA (section)				1		1			1
In situ RNA (whole mount)	1		1
In situ reporter (knock in)					1	1			3	1	1	1
Northern blot										2
Western blot													1
RT-PCR		1	1		1		1	1	2	1				3
cDNA clones	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hs2st1  heparan sulfate 2-O-sulfotransferase 1   (Synonyms: Hs2st, mKIAA0448)
Results	Reference
1	J:297362 Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A, Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59
1	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
5	J:48481 Bullock SL, Fletcher JM, Beddington RS, Wilson VA, Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 1998 Jun 15;12(12):1894-906
1	J:233810 Chan WK, Howe K, Clegg JM, Guimond SE, Price DJ, Turnbull JE, Pratt T, 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS One. 2015;10(6):e0130147
1	J:255068 Chan WK, Price DJ, Pratt T, FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain. Biol Open. 2017 Dec 15;6(12):1933-1942
1	J:213873 Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC, FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development. 2014 Jul;141(13):2691-701
5	J:272376 Clegg JM, Parkin HM, Mason JO, Pratt T, Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism. J Neurosci. 2019 Feb 20;39(8):1386-1404
2	J:169370 Conway CD, Howe KM, Nettleton NK, Price DJ, Mason JO, Pratt T, Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development. J Neurosci. 2011 Feb 9;31(6):1955-70
1	J:296619 Fan Y, Richelme S, Avazeri E, Audebert S, Helmbacher F, Dono R, Maina F, Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. PLoS Genet. 2015;11(9):e1005533
3*	J:81601 Ford-Perriss M, Guimond SE, Greferath U, Kita M, Grobe K, Habuchi H, Kimata K, Esko JD, Murphy M, Turnbull JE, Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology. 2002 Nov;12(11):721-7
2	J:122656 Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K, Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
2*	J:123454 McLaughlin D, Karlsson F, Tian N, Pratt T, Bullock SL, Wilson VA, Price DJ, Mason JO, Specific modification of heparan sulphate is required for normal cerebral cortical development. Mech Dev. 2003 Dec;120(12):1481-8
2	J:353621 Patel VN, Aure MH, Choi SH, Ball JR, Lane ED, Wang Z, Xu Y, Zheng C, Liu X, Martin D, Pailin JY, Prochazkova M, Kulkarni AB, van Kuppevelt TH, Ambudkar IS, Liu J, Hoffman MP, Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
1	J:320380 Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, van Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP, Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Matrix Biol. 2021 Sep;103-104:37-57
2	J:110040 Pratt T, Conway CD, Tian NM, Price DJ, Mason JO, Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm. J Neurosci. 2006 Jun 28;26(26):6911-23
1	J:185788 Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X, Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011 Apr 22;286(16):14435-44