Gene Expression Literature Summary

• Symbol: Nr5a2
• Name: nuclear receptor subfamily 5, group A, member 2
• ID: MGI:1346834

48 matching records from 48 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)											1					1	1		3		2		4		1		4		1	2		1	1		5
In situ RNA (section)										1	2		2	1		1	2	1	3		3	1	2		4	1	7		3	1	1		1		6
Immunohistochemistry (whole mount)		2		2	2		3	1									1	1	1	1															2
In situ RNA (whole mount)							1				1	1	1	1					1								1		2
In situ reporter (knock in)					1		1														1						1								1
Northern blot												1								1								1			1				2
Western blot																																1			1
RT-PCR	1	1	2	3	2	2	2		1	1	1	1	2		1		1		1	1	1		4	1	3		2	1	2	1	1	3	2	1	12
cDNA clones																																			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nr5a2  nuclear receptor subfamily 5, group A, member 2   (Synonyms: D1Ertd308e, Ftf, LRH-1, UF2-H3B)
Results	Reference
8*	J:85764 Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J, Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol. 2003 Oct;23(19):6713-24
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
2	J:89122 Bland ML, Fowkes RC, Ingraham HA, Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol. 2004 Apr;18(4):941-52
1	J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
3	J:334568 Chen HJ, Barske L, Talbot JC, Dinwoodie OM, Roberts RR, Farmer DT, Jimenez C, Merrill AE, Tucker AS, Crump JG, Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Dev Cell. 2023 Mar 27;58(6):461-473.e7
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
3	J:337474 Cobo I, Paliwal S, Bodas C, Felipe I, Melia-Aloma J, Torres A, Martinez-Villarreal J, Malumbres M, Garcia F, Millan I, Del Pozo N, Park JC, MacDonald RJ, Munoz J, Mendez R, Real FX, NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761
1	J:344351 Deska-Gauthier D, Borowska-Fielding J, Jones C, Zhang H, MacKay CS, Michail R, Bennett LA, Bikoff JB, Zhang Y, Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity. Cell Rep. 2023 Dec 29;43(1):113635
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5	J:355264 Festuccia N, Vandormael-Pournin S, Chervova A, Geiselmann A, Langa-Vives F, Coux RX, Gonzalez I, Collet GG, Cohen-Tannoudji M, Navarro P, Nr5a2 is dispensable for zygotic genome activation but essential for morula development. Science. 2024 Oct 4;386(6717):eadg7325
11*	J:107644 Gao DM, Wang LF, Liu J, Kong YY, Wang Y, Xie YH, Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter. FEBS Lett. 2006 Mar 20;580(7):1702-8
1	J:255620 Gao T, Zhou D, Yang C, Singh T, Penzo-Mendez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ, Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1
1	J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
7*	J:97625 Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ, Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Mol Cell Biol. 2005 May;25(9):3492-505
1	J:117667 Gu P, Le Menuet D, Chung AC, Cooney AJ, Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression. Mol Cell Biol. 2006 Dec;26(24):9471-83
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
9	J:214089 Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ, The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
6*	J:100239 Hinshelwood MM, Shelton JM, Richardson JA, Mendelson CR, Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development. Dev Dyn. 2005 Sep;234(1):159-68
4	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
4	J:170546 Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, Rohrer H, Matsas R, Politis PK, Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol. 2010;8(12):e1000565
2*	J:212462 Kanno M, Yazawa T, Kawabe S, Imamichi Y, Usami Y, Ju Y, Matsumura T, Mizutani T, Fujieda S, Miyamoto K, Sex-determining region Y-box 2 and GA-binding proteins regulate the transcription of liver receptor homolog-1 in early embryonic cells. Biochim Biophys Acta. 2014 May;1839(5):406-14
8	J:111670 Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I, Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006 Aug 15;20(16):2293-305
5	J:343873 Lai F, Li L, Hu X, Liu B, Zhu Z, Liu L, Fan Q, Tian H, Xu K, Lu X, Li Q, Feng K, Wang L, Lin Z, Deng H, Li J, Xie W, NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos. Cell Res. 2023 Dec;33(12):952-966
3	J:229014 Marty-Santos L, Cleaver O, Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12
10	J:91695 Pare JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Belanger L, The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem. 2004 May 14;279(20):21206-16
1	J:118350 Qin J, Suh JM, Kim BJ, Yu CT, Tanaka T, Kodama T, Tsai MJ, Tsai SY, The expression pattern of nuclear receptors during cerebellar development. Dev Dyn. 2007 Mar;236(3):810-20
1	J:306082 Quilichini E, Fabre M, Nord C, Dirami T, Le Marec A, Cereghini S, Pasek RC, Gannon M, Ahlgren U, Haumaitre C, Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease. J Pathol. 2021 May;254(1):31-45
1	J:280142 Quintana-Urzainqui I, Kozic Z, Mitra S, Tian T, Manuel M, Mason JO, Price DJ, Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent. iScience. 2018 Dec 21;10:171-191
7*	J:58630 Rausa FM, Galarneau L, Belanger L, Costa RH, The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas. Mech Dev. 1999 Dec;89(1-2):185-8
7	J:306614 Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, Yabuta Y, Iwatani C, Tsuchiya H, Yamamoto T, Seita Y, Saitou M, The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021 May 4;35(5):109075
1	J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1	J:338451 Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H, Sakai T, Yoshimura T, Miyasaka M, Hayasaka H, Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes. Curr Res Immunol. 2022;3:175-185
4	J:241169 Stergiopoulos A, Politis PK, Nuclear receptor NR5A2 controls neural stem cell fate decisions during development. Nat Commun. 2016 Jul 22;7:12230
2	J:115933 Suh JM, Yu CT, Tang K, Tanaka T, Kodama T, Tsai MJ, Tsai SY, The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006 Dec;20(12):3412-20
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2	J:138818 Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I, Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell. 2008 Aug 22;31(4):531-43
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:183714 Thompson N, Gesina E, Scheinert P, Bucher P, Grapin-Botton A, RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol. 2012 Mar;32(6):1189-99
1*	J:199245 Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K, Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 2013 Jun 4;17(6):916-28
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:102143 Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS, High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Gene Expr Patterns. 2006 Jan;6(2):213-24
3	J:108702 Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM, Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15;20(10):1308-20
6*	J:346140 Zhao Y, Zhang M, Liu J, Hu X, Sun Y, Huang X, Li J, Lei L, Nr5a2 ensures inner cell mass formation in mouse blastocyst. Cell Rep. 2024 Feb 21;43(3):113840
2	J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14