Gene Expression Literature Summary

• Symbol: Ror2
• Name: receptor tyrosine kinase-like orphan receptor 2
• ID: MGI:1347521

53 matching records from 53 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E3	E3.5	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)											2	6		5	8		3		7	4	3			2		2
In situ RNA (section)									2			3	1	3	6	1	7	1	8	4	4	1	3	4	2	6
In situ RNA (whole mount)							1		2		4	3	1	2	1		2		1	1	1			1
In situ reporter (knock in)											1	1		1	2	2	2	1								2
Northern blot								1		1			1							1		1			1	1
Western blot											1			3	2		2		2				1		1	1
RT-PCR	1	1	1	1	1	1								2	2		1		3	2				1		3
cDNA clones														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ror2  receptor tyrosine kinase-like orphan receptor 2   (Synonyms: Ntrkr2)
Results	Reference
1*	J:176660 Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM, A high-resolution molecular atlas of the fetal mouse lower urogenital tract. Dev Dyn. 2011 Oct;240(10):2364-77
5	J:69867 Al-Shawi R, Ashton SV, Underwood C, Simons JP, Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev Genes Evol. 2001 Apr;211(4):161-71
1	J:313969 Alcantara MC, Suzuki K, Acebedo AR, Sakamoto Y, Nishita M, Minami Y, Kikuchi A, Yamada G, Stage-dependent function of Wnt5a during male external genitalia development. Congenit Anom (Kyoto). 2021 Nov;61(6):212-219
9*	J:213602 Arora R, Altman E, Tran ND, Laird DJ, Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug;243(8):1037-45
1*	J:200762 Buttler K, Becker J, Pukrop T, Wilting J, Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice. Dev Biol. 2013 Sep 15;381(2):365-76
1	J:229484 Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, Perez-Morga D, Orecchia V, Poli V, Merlo GR, The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54
5*	J:60754 DeChiara TM, Kimble RB, Poueymirou WT, Rojas J, Masiakowski P, Valenzuela DM, Yancopoulos GD, Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet. 2000 Mar;24(3):271-4
4	J:197303 Endo M, Doi R, Nishita M, Minami Y, Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex. J Cell Sci. 2012 Apr 15;125(Pt 8):2017-29
2	J:239715 Galazo MJ, Emsley JG, Macklis JD, Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106
6	J:169766 Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y, Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell. 2011 Feb 15;20(2):163-76
1*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
7*	J:122362 Harwood BN, Cross SK, Radford EE, Haac BE, de Vries WN, Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Dev Dyn. 2008;237(4):1099-1111
1	J:144627 He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y, Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development. 2008 Dec;135(23):3871-9
4	J:182150 Ho HY, Susman MW, Bikoff JB, Ryu YK, Jonas AM, Hu L, Kuruvilla R, Greenberg ME, Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
3	J:308827 Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V, MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 May 15;148(10):dev192054
3	J:266265 Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M, Morimoto M, Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nat Commun. 2018 Jul 19;9(1):2816
2	J:179805 Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV, Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec;7(12):e1002428
4*	J:167829 Lin M, Li L, Liu C, Liu H, He F, Yan F, Zhang Y, Chen Y, Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth. Dev Dyn. 2011 Feb;240(2):432-40
1	J:213772 Liu C, Lin C, Gao C, May-Simera H, Swaroop A, Li T, Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3(9):861-70
1	J:179217 Liu HX, Grosse AS, Iwatsuki K, Mishina Y, Gumucio DL, Mistretta CM, Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development. Dev Biol. 2012 Jan 1;361(1):39-56
9*	J:70589 Matsuda T, Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y, Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech Dev. 2001 Jul;105(1-2):153-6
1	J:283040 McKenzie MG, Cobbs LV, Dummer PD, Petros TJ, Halford MM, Stacker SA, Zou Y, Fishell GJ, Au E, Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons. Neuron. 2019 Sep 4;103(5):853-864.e4
3*	J:156970 Mikels A, Minami Y, Nusse R, Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem. 2009 Oct 30;284(44):30167-76
2*	J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
2	J:187747 Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS, Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
1	J:327818 Murphy P, Armit C, Hill B, Venkataraman S, Frankel P, Baldock RA, Davidson DR, Integrated analysis of Wnt signalling system component gene expression. Development. 2022 Aug 15;149(16):dev200312
3*	J:281425 Nakaniwa M, Kawasaki M, Kawasaki K, Yamada A, Meguro F, Takeyasu M, Ohazama A, Primary cilia in murine palatal rugae development. Gene Expr Patterns. 2019 Jun 19;34:119062
9	J:223676 Nishita M, Qiao S, Miyamoto M, Okinaka Y, Yamada M, Hashimoto R, Iijima K, Otani H, Hartmann C, Nishinakamura R, Minami Y, Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol Cell Biol. 2014 Aug;34(16):3096-105
10	J:57217 Oishi I, Takeuchi S, Hashimoto R, Nagabukuro A, Ueda T, Liu ZJ, Hatta T, Akira S, Matsuda Y, Yamamura H, Otani H, Minami Y, Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
3*	J:119598 Oldridge M, Fortuna AM, Maringa M, Propping P, Mansour S, Pollitt C, DeChiara TM, Kimble RB, Valenzuela DM, Yancopoulos GD, Wilkie AO, Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat Genet. 2000 Mar;24(3):275-8
1	J:350324 Polsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP, Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. Development. 2024 Jun 15;151(12):dev202596
2	J:317559 Qi X, Okinaka Y, Nishita M, Minami Y, Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation. Genes Cells. 2016 Apr;21(4):325-34
2	J:134490 Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN, The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May;135(9):1713-23
2*	J:243411 Rutledge EA, Benazet JD, McMahon AP, Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188
6*	J:88955 Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S, Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn. 2004 Feb;229(2):400-10
2	J:331869 Shi W, Filmus J, Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling. Dev Dyn. 2022 Dec;251(12):2015-2028
2	J:298037 Shi W, Kaneiwa T, Cydzik M, Gariepy J, Filmus J, Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling. Matrix Biol. 2020 Jun;88:19-32
2	J:60125 Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y, Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells. 2000 Jan;5(1):71-8
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
5*	J:155130 van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos S, Stricker S, The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochem Biophys Res Commun. 2009 Dec 11;390(2):211-6
11*	J:297051 Wang S, Roy JP, Tomlinson AJ, Wang EB, Tsai YH, Cameron L, Underwood J, Spence JR, Walton KD, Stacker SA, Gumucio DL, Lechler T, RYK-mediated filopodial pathfinding facilitates midgut elongation. Development. 2020 Oct 27;147(20):dev195388
1	J:291369 Weissenbock M, Latham R, Nishita M, Wolff LI, Ho HH, Minami Y, Hartmann C, Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants. Genes Cells. 2019 Apr;24(4):307-317
2	J:163602 Witte F, Chan D, Economides AN, Mundlos S, Stricker S, Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14211-6
8	J:156943 Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Hatta T, Nishita M, Minami Y, Otani H, Ror2 is required for midgut elongation during mouse development. Dev Dyn. 2010 Jan 8;239(3):941-953
1*	J:179664 Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y, Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase (MMP-13) Expression. J Biol Chem. 2012 Jan 6;287(2):1588-99
2*	J:140886 Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H, Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell. 2008 Jul;15(1):23-36
4	J:310320 Yang T, Bassuk AG, Stricker S, Fritzsch B, Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons. Cell Tissue Res. 2014 Sep;357(3):549-61
1	J:266389 Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR, The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018 Jul 19;9(1):2815
1	J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72
1	J:177881 Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA, Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS One. 2011;6(9):e24608
1	J:257510 Zhu XJ, Fang Y, Xiong Y, Wang M, Yang X, Li Y, Zhang X, Dai ZM, Qiu M, Zhang Z, Zhang Z, Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly. FEBS Lett. 2018 Feb;592(3):356-368