Gene Expression Literature Summary

• Symbol: Ccl21a
• Name: C-C motif chemokine ligand 21 (serine)
• ID: MGI:1349183

31 matching records from 31 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	P
Immunohistochemistry (section)		1	1	4	3	2		5	2			2	9
In situ RNA (section)				1	2	1		1	1				1
Immunohistochemistry (whole mount)							1				1	1
In situ RNA (whole mount)			1						1			1
RT-PCR	1			1	2	3		1	1	1		2	5
cDNA clones				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ccl21a  C-C motif chemokine ligand 21 (serine)   (Synonyms: 6CKBAC2, 6Ckine, ALP, CKb9, Exodus-2, Gm1987, Scya21, Scya21b, SLC, Tca4)
Results	Reference
1	J:159868 Benezech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamano JH, Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010 Apr 15;184(8):4521-30
3	J:71805 Bleul CC, Boehm T, Chemokines define distinct microenvironments in the developing thymus. Eur J Immunol. 2000 Dec;30(12):3371-9
1	J:76133 Brennan J, Karl J, Capel B, Divergent Vascular Mechanisms Downstream of Sry Establish the Arterial System in the XY Gonad. Dev Biol. 2002 Apr 15;244(2):418-28
1	J:203143 Bryson JL, Griffith AV, Hughes B 3rd, Saito F, Takahama Y, Richie ER, Manley NR, Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus. PLoS One. 2013;8(6):e65196
1	J:286704 Cheng HW, Onder L, Novkovic M, Soneson C, Lutge M, Pikor N, Scandella E, Robinson MD, Miyazaki JI, Tersteegen A, Sorg U, Pfeffer K, Rulicke T, Hehlgans T, Ludewig B, Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun. 2019 Apr 15;10(1):1739
1	J:283927 Choi SY, Bae H, Jeong SH, Park I, Cho H, Hong SP, Lee DH, Lee CK, Park JS, Suh SH, Choi J, Yang MJ, Jang JY, Onder L, Moon JH, Jeong HS, Adams RH, Kim JM, Ludewig B, Song JH, Lim DS, Koh GY, YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020 Jan 24;11(1):519
1	J:318898 Fujimori S, Ohigashi I, Abe H, Matsushita Y, Katagiri T, Taketo MM, Takahama Y, Takada S, Fine-tuning of beta-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. Elife. 2022 Jan 19;11:e69088
1	J:139331 Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H, Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 1;177(7):4276-80
3	J:322001 Gao H, Cao M, Deng K, Yang Y, Song J, Ni M, Xie C, Fan W, Ou C, Huang D, Lin L, Liu L, Li Y, Sun H, Cheng X, Wu J, Xia C, Deng X, Mou L, Chen P, The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis. Front Immunol. 2022;13:805451
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4*	J:157503 Laan M, Kisand K, Kont V, Moll K, Tserel L, Scott HS, Peterson P, Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol. 2009 Dec 15;183(12):7682-91
2	J:324834 Lenti E, Genovese L, Bianchessi S, Maurizio A, Sain SB, di Lillo A, Mattavelli G, Harel I, Bernassola F, Hehlgans T, Pfeffer K, Crosti M, Abrignani S, Evans SM, Sitia G, Guimaraes-Camboa N, Russo V, van de Pavert SA, Garcia-Manteiga JM, Brendolan A, Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors. Immunity. 2022 Apr 12;55(4):606-622.e6
2*	J:121311 Liu Z, Yu S, Manley NR, Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
4	J:320345 Montero-Herradon S, Garcia-Ceca J, Sanchez Del Collado B, Alfaro D, Zapata AG, Eph/ephrin-B-mediated cell-to-cell interactions govern MTS20(+) thymic epithelial cell development. Histochem Cell Biol. 2016 Aug;146(2):167-82
1*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
1	J:149138 Norrmen C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Yla-Herttuala S, Alitalo K, Petrova TV, FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol. 2009 May 4;185(3):439-57
1	J:217542 Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H, Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep. 2014 Dec;15(12):1297-304
2	J:259045 Onder L, Morbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rulicke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B, Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity. 2017 Jul 18;47(1):80-92.e4
1	J:305472 Prados A, Onder L, Cheng HW, Morbe U, Lutge M, Gil-Cruz C, Perez-Shibayama C, Koliaraki V, Ludewig B, Kollias G, Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol. 2021 Apr;22(4):510-519
1	J:112368 Sato T, Endoh M, Yoshida H, Yasuo S, Katsuno T, Saito Y, Isono K, Koseki H, Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation. Gene. 2006 Sep 1;379:166-74
2	J:273849 Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC, Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia. FASEB J. 2018 May;32(5):2574-2586
2	J:164924 Stimamiglio MA, Jimenez E, Silva-Barbosa SD, Alfaro D, Garcia-Ceca JJ, Munoz JJ, Cejalvo T, Savino W, Zapata A, EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonization. J Leukoc Biol. 2010 Sep;88(3):483-94
3*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
5*	J:262369 Taya Y, Sato K, Shirako Y, Soeno Y, Migration of lymphatic endothelial cells and lymphatic vascular development in the craniofacial region of embryonic mice. Int J Dev Biol. 2018;62(4-5):293-301
1	J:336858 Vallecillo-Garcia P, Orgeur M, Comai G, Poehle-Kronnawitter S, Fischer C, Gloger M, Dumas CE, Giesecke-Thiel C, Sauer S, Tajbakhsh S, Hopken UE, Stricker S, A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity. 2023 Jun 13;56(6):1204-1219.e8
2	J:157747 van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, Hopken UE, Lipp M, Niederreither K, Blomhoff R, Sitnik K, Agace WW, Randall TD, de Jonge WJ, Mebius RE, Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol. 2009 Nov;10(11):1193-9
3*	J:75859 Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G, An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 2002 Apr 2;21(7):1505-13
1	J:354242 Wu Y, Chen S, Huang G, Zhang L, Zhong L, Feng Y, Wen P, Liu J, Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system. Theranostics. 2024;14(12):4894-4915
3	J:257967 Wurm S, Steege A, Rom-Jurek EM, van Roeyen CR, Kurtz A, Banas B, Banas MC, CCR7 Is Important for Mesangial Cell Physiology and Repair. J Histochem Cytochem. 2018 Jan;66(1):7-22
1	J:287680 Yamamoto H, Kon T, Omori Y, Furukawa T, Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. Cell Rep. 2020 Jan 21;30(3):658-671.e5
4	J:146244 Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT, Hafen K, Tsukamoto N, Amagai T, Taketo MM, Krenger W, Hollander GA, Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol. 2009 Mar 1;182(5):2997-3007