Gene Expression Literature Summary

• Symbol: Map4k4
• Name: mitogen-activated protein kinase kinase kinase kinase 4
• ID: MGI:1349394

7 matching records from 7 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E10.5	E12.5	E13.5	E14.5	E15.5	E18.5	E	P
Immunohistochemistry (section)					1			1		1
In situ RNA (section)			1	1		2
In situ RNA (whole mount)	1	1
Northern blot										1
Western blot									1
RT-PCR					2		2			3
cDNA clones									1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Map4k4  mitogen-activated protein kinase kinase kinase kinase 4   (Synonyms: 9430080K19Rik, Nik)
Results	Reference
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5	J:336925 Huang H, Kuang X, Zou Y, Zeng J, Du H, Tang H, Long C, Mao Y, Yu X, Wen C, Yan J, Shen H, MAP4K4 is involved in the neuronal development of retinal photoreceptors. Exp Eye Res. 2023 Jun 7;233:109524
3*	J:292617 Lin YC, Lu YH, Lee YC, Hung CS, Lin JC, Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism. Biochim Biophys Acta Gene Regul Mech. 2020 Jul 3;1863(9):194601
3	J:317583 Peng HY, Liang YC, Tan TH, Chuang HC, Lin YJ, Lin JC, RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. Int J Mol Sci. 2018 Sep 6;19(9):2646
3*	J:75974 Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E, A Conserved Interaction between beta1 Integrin/PAT-3 and Nck-Interacting Kinase/MIG-15 that Mediates Commissural Axon Navigation in C. elegans. Curr Biol. 2002 Apr 16;12(8):622-31
3*	J:39300 Su YC, Han J, Xu S, Cobb M, Skolnik EY, NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997 Mar 17;16(6):1279-90
2*	J:68215 Xue Y, Wang X, Li Z, Gotoh N, Chapman D, Skolnik EY, Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72