Gene Expression Literature Summary

• Symbol: Nr6a1
• Name: nuclear receptor subfamily 6, group A, member 1
• ID: MGI:1352459

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)															1						1									5
In situ RNA (section)									1	3		3	1	5	5		2	2		2	2		1	1				1	1	8
Immunohistochemistry (whole mount)	1	1		1	1	1	1																							1
In situ RNA (whole mount)							1		1	3	1	5	2	3	2			2		1	1		2		1		1
In situ reporter (knock in)										1								1		1	1		1		1		1			2
Northern blot												1		1	2		1	1			1									2
Western blot											1		1																	1
RT-PCR			2	2	1	1	1	1				2		3	2	1		1	1			1	1		1	1			1	8
RNase protection												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nr6a1  nuclear receptor subfamily 6, group A, member 1   (Synonyms: 1700113M01Rik, Gcnf, NCNF)
Results	Reference
2	J:146589 Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D, Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. J Neurosci. 2009 Feb 18;29(7):2113-24
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
6	J:332213 Chang YC, Manent J, Schroeder J, Wong SFL, Hauswirth GM, Shylo NA, Moore EL, Achilleos A, Garside V, Polo JM, Trainor P, McGlinn E, Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development. Nat Commun. 2022 Dec 15;13(1):7766
2	J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
8	J:67377 Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW, Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan;21(2):663-77
4*	J:108393 Chung AC, Xu X, Niederreither KA, Cooney AJ, Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006 May 1;293(1):13-24
3*	J:71786 Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, Sylvester I, Scholer HR, Cooney AJ, Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell. 2001 Sep;1(3):377-87
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
3*	J:231259 Krill KT, Gurdziel K, Heaton JH, Simon DP, Hammer GD, Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol. 2013 May;27(5):754-68
4*	J:80978 Lan ZJ, Chung AC, Xu X, DeMayo FJ, Cooney AJ, The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain. J Biol Chem. 2002 Dec 27;277(52):50660-7
9*	J:81162 Lan ZJ, Gu P, Xu X, Cooney AJ, Expression of the orphan nuclear receptor, germ cell nuclear factor, in mouse gonads and preimplantation embryos. Biol Reprod. 2003 Jan;68(1):282-9
4*	J:149711 Lan ZJ, Xu X, Chung AC, Cooney AJ, Extra-germ cell expression of mouse nuclear receptor subfamily 6, group A, member 1 (NR6A1). Biol Reprod. 2009 May;80(5):905-12
4	J:311847 Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T, Identification of a link between Wnt/beta-catenin signalling and the cell fusion pathway. Nat Commun. 2011 Nov 22;2:548
4	J:79927 Mehta DV, Kim YS, Dixon D, Jetten AM, Characterization of the Expression of the Retinoid-related, Testis-associated Receptor (RTR) in Trophoblasts. Placenta. 2002 Apr;23(4):281-7
2*	J:52247 Morasso MI, Grinberg A, Robinson G, Sargent TD, Mahon KA, Placental failure in mice lacking the homeobox gene Dlx3. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):162-7
3	J:204241 Okumura LM, Lesch BJ, Page DC, The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS One. 2013;8(6):e66062
1	J:118350 Qin J, Suh JM, Kim BJ, Yu CT, Tanaka T, Kodama T, Tsai MJ, Tsai SY, The expression pattern of nuclear receptors during cerebellar development. Dev Dyn. 2007 Mar;236(3):810-20
1	J:92421 Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM, NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
2	J:194978 Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR, The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013 May 1;22(9):1791-806
1	J:158290 Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
12*	J:221000 Sabour D, Xu X, Chung AC, Le Menuet D, Ko K, Tapia N, Arauzo-Bravo MJ, Gentile L, Greber B, Hubner K, Sebastiano V, Wu G, Scholer HR, Cooney AJ, Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS One. 2014;9(8):e103985
2	J:262281 Sarkar AA, Sabatino JA, Sugrue KF, Zohn IE, Abnormal labyrinthine zone in the Hectd1-null placenta. Placenta. 2016 Feb;38:16-23
4	J:61094 Schreiber J, Riethmacher-Sonnenberg E, Riethmacher D, Tuerk EE, Enderich J, Bosl MR, Wegner M, Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. Mol Cell Biol. 2000 Apr;20(7):2466-74
5*	J:136716 Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC, Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development. 2008 Jun;135(12):2083-91
2	J:115933 Suh JM, Yu CT, Tang K, Tanaka T, Kodama T, Tsai MJ, Tsai SY, The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006 Dec;20(12):3412-20
13*	J:223989 Susens U, Aguiluz JB, Evans RM, Borgmeyer U, The germ cell nuclear factor mGCNF is expressed in the developing nervous system. Dev Neurosci. 1997;19(5):410-20
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:102143 Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS, High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Gene Expr Patterns. 2006 Jan;6(2):213-24