Gene Expression Literature Summary

• Symbol: Foxe3
• Name: forkhead box E3
• ID: MGI:1353569

62 matching records from 62 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			1	2	5	2	4		12	3	12		1	6	1		2	3	5
In situ RNA (section)			2	2	8	1	6		9		7			1				1
In situ RNA (whole mount)	1	1	4	5	7		2	1	2
Northern blot					1
Western blot																			1
RT-PCR					2		2		4	1	3	1	2	3	1	1	2		7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxe3  forkhead box E3   (Synonyms: FREAC8, rct)
Results	Reference
1	J:274581 Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA, Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract. Hum Genet. 2015 Jul;134(7):717-35
5*	J:205268 Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J, Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol. 2013;57(9-10):741-51
2	J:237492 Antosova B, Smolikova J, Klimova L, Lachova J, Bendova M, Kozmikova I, Machon O, Kozmik Z, The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6. PLoS Genet. 2016 Dec;12(12):e1006441
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
2	J:264269 Azimi M, Le TT, Brown NL, Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018 Jul - Aug;102:40-52
4*	J:119940 Blixt A, Landgren H, Johansson BR, Carlsson P, Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol. 2007 Feb 1;302(1):218-29
6	J:59880 Blixt A, Mahlapuu M, Aitola M, Pelto-Huikko M, Enerback S, Carlsson P, A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev. 2000 Jan 15;14(2):245-54
14*	J:63706 Brownell I, Dirksen M, Jamrich M, Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis. 2000 Jun;27(2):81-93
1	J:158529 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V, Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
2*	J:136314 Burns CJ, Zhang J, Brown EC, Van Bibber AM, Van Es J, Clevers H, Ishikawa TO, Taketo MM, Vetter ML, Fuhrmann S, Investigation of Frizzled-5 during embryonic neural development in mouse. Dev Dyn. 2008 Jun;237(6):1614-26
1	J:198381 Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X, An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes. J Biol Chem. 2013 Apr 26;288(17):12130-41
1	J:212971 Cavalheiro GR, Matos-Rodrigues GE, Gomes AL, Rodrigues PM, Martins RA, c-myc regulates cell proliferation during lens development. PLoS One. 2014;9(2):e87182
1	J:223109 Choi JJ, Ting CT, Trogrlic L, Milevski SV, Familari M, Martinez G, de Iongh RU, A role for smoothened during murine lens and cornea development. PLoS One. 2014;9(9):e108037
2	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
3*	J:225905 Dash S, Dang CA, Beebe DC, Lachke SA, Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly. Dev Dyn. 2015 Oct;244(10):1313-27
1	J:73524 Dimanlig PV, Faber SC, Auerbach W, Makarenkova HP, Lang RA, The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 2001 Nov;128(22):4415-24
1*	J:73525 Faber SC, Dimanlig P, Makarenkova HP, Shirke S, Ko K, Lang RA, Fgf receptor signaling plays a role in lens induction. Development. 2001 Nov;128(22):4425-38
1	J:170649 Garcia CM, Huang J, Madakashira BP, Liu Y, Rajagopal R, Dattilo L, Robinson ML, Beebe DC, The function of FGF signaling in the lens placode. Dev Biol. 2011 Mar 1;351(1):176-85
1	J:77351 Goudreau G, Petrou P, Reneker LW, Graw J, Loster J, Gruss P, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
5	J:235665 He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A, Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47
1*	J:144758 Ho HY, Chang KH, Nichols J, Li M, Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev. 2009 Jan-Feb;126(1-2):18-29
1*	J:222440 Huang J, Liu Y, Oltean A, Beebe DC, Bmp4 from the optic vesicle specifies murine retina formation. Dev Biol. 2015 Jun 1;402(1):119-26
2	J:196835 Kerr CL, Huang J, Williams T, West-Mays JA, Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation. Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3316-30
4	J:236874 Khan SY, Vasanth S, Kabir F, Gottsch JD, Khan AO, Chaerkady R, Lee MC, Leitch CC, Ma Z, Laux J, Villasmil R, Khan SN, Riazuddin S, Akram J, Cole RN, Talbot CC, Pourmand N, Zaghloul NA, Hejtmancik JF, Riazuddin SA, FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Nat Commun. 2016 Apr 06;7:10953
1	J:208421 Klimova L, Kozmik Z, Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
3	J:232427 Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X, Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM, FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61
2	J:181400 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V, Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6887-97
3	J:181272 Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL, Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
1	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
2	J:116102 Liu W, Lagutin OV, Mende M, Streit A, Oliver G, Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J. 2006 Nov 15;25(22):5383-95
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
2	J:207861 Manthey AL, Lachke SA, FitzGerald PG, Mason RW, Scheiblin DA, McDonald JH, Duncan MK, Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb;131:86-110
1	J:101355 Medina-Martinez O, Brownell I, Amaya-Manzanares F, Hu Q, Behringer RR, Jamrich M, Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol. 2005 Oct;25(20):8854-63
4	J:151273 Medina-Martinez O, Shah R, Jamrich M, Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009 Mar 30;238(9):2193-2201
1	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:131815 Pontoriero GF, Deschamps P, Ashery-Padan R, Wong R, Yang Y, Zavadil J, Cvekl A, Sullivan S, Williams T, West-Mays JA, Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn. 2008 Mar;237(3):602-17
1	J:154465 Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC, The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol. 2009 Nov 15;335(2):305-16
4	J:138714 Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL, Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol. 2008 Sep 1;321(1):111-22
3*	J:160146 Rowan S, Siggers T, Lachke SA, Yue Y, Bulyk ML, Maas RL, Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev. 2010 May 15;24(10):980-5
3	J:180791 Saravanamuthu SS, Le TT, Gao CY, Cojocaru RI, Pandiyan P, Liu C, Zhang J, Zelenka PS, Brown NL, Conditional ablation of the Notch2 receptor in the ocular lens. Dev Biol. 2012 Feb 15;362(2):219-29
5	J:343554 Sun Q, Li J, Ma J, Zheng Y, Ju R, Li X, Ren X, Huang L, Chen R, Tan X, Luo L, JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):15
1*	J:141960 Swindell EC, Liu C, Shah R, Smith AN, Lang RA, Jamrich M, Eye formation in the absence of retina. Dev Biol. 2008 Oct 1;322(1):56-64
1	J:270543 Tanahashi H, Suzuki T, Deletion of Lrp4 increases the incidence of microphthalmia. Biochem Biophys Res Commun. 2018 Nov 30;506(3):478-484
4*	J:277247 Vetrivel S, Tiso N, Kugler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Gotz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Holter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Racz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Ostereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Hrabe de Angelis M, Graw J, Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019 Apr 13;
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
7	J:177496 Wada K, Maeda YY, Watanabe K, Oshio T, Ueda T, Takahashi G, Yokohama M, Saito J, Seki Y, Takahama S, Ishii R, Shitara H, Taya C, Yonekawa H, Kikkawa Y, A deletion in a cis element of Foxe3 causes cataracts and microphthalmia in rct mice. Mamm Genome. 2011 Dec;22(11-12):693-702
5	J:269956 Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y, Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
4	J:270322 Wada K, Saito J, Yamaguchi M, Seki Y, Furugori M, Takahashi G, Nishito Y, Matsuda H, Shitara H, Kikkawa Y, Pde6b(rd1) mutation modifies cataractogenesis in Foxe3(rct) mice. Biochem Biophys Res Commun. 2018 Jan 29;496(1):231-237
1	J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
1	J:276573 Wiegering A, Petzsch P, Kohrer K, Ruther U, Gerhardt C, GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis. Dev Biol. 2019 Jun 15;450(2):141-154
1	J:161172 Wiley LA, Dattilo LK, Kang KB, Giovannini M, Beebe DC, The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3611-8
1	J:174241 Wiley LA, Rajagopal R, Dattilo LK, Beebe DC, The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Dis Model Mech. 2011 Jul-Aug;4(4):484-95
1	J:211220 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A, Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 2013 Dec;41(22):10199-214
1	J:342871 Xiang J, Pompetti AJ, Faranda AP, Wang Y, Novo SG, Li DW, Duncan MK, ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment. Cells. 2023 Nov 16;12(22)
3	J:82312 Yamada R, Mizutani-Koseki Y, Hasegawa T, Osumi N, Koseki H, Takahashi N, Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development. 2003 May;130(9):1759-70
1	J:93910 Yamada R, Mizutani-Koseki Y, Koseki H, Takahashi N, Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004 Oct 15;274(2):295-307
3	J:213336 Yan X, Sabrautzki S, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Hrabe de Angelis M, Graw J, Peroxidasin is essential for eye development in the mouse. Hum Mol Genet. 2014 Nov 1;23(21):5597-614
1	J:101730 Yoshimoto A, Saigou Y, Higashi Y, Kondoh H, Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005 Oct;132(20):4437-48
2	J:271942 Yu Z, Yu W, Liu J, Wu D, Wang C, Zhang J, Zhao J, Lens-specific deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway. J Int Med Res. 2018 Jul;46(7):2843-2855
3*	J:136711 Zhao H, Yang T, Madakashira BP, Thiels CA, Bechtle CA, Garcia CM, Zhang H, Yu K, Ornitz DM, Beebe DC, Robinson ML, Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88
1	J:106041 Zhao H, Yang Y, Partanen J, Ciruna BG, Rossant J, Robinson ML, Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006;12:15-25
3	J:184697 Zhao J, Kawai K, Wang H, Wu D, Wang M, Yue Z, Zhang J, Liu YH, Loss of Msx2 Function Down-Regulates the FoxE3 Expression and Results in Anterior Segment Dysgenesis Resembling Peters Anomaly. Am J Pathol. 2012 Jun;180(6):2230-9