Gene Expression Literature Summary

• Symbol: Irx5
• Name: Iroquois homeobox 5
• ID: MGI:1859086

70 matching records from 70 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E18.5	E	P
Immunohistochemistry (section)													1	1	1			5
In situ RNA (section)		1	1	1	7	1	3		7	1	8	8	3	6	3	4	4	9
In situ RNA (whole mount)	1	3	2	1	13	5	11	1	6	1	3	4	3	1			1
In situ reporter (knock in)			1		1	1	1		1		3	1	2	1	1			2
Western blot									1									2
RT-PCR					5	2	3		1	3	1	6	3	2	1			6
cDNA clones						1					1	1	1					2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Irx5  Iroquois homeobox 5
Results	Reference
6	J:220960 Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y, Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
15	J:62062 Bosse A, Stoykova A, Nieselt-Struwe K, Chowdhury K, Copeland NG, Jenkins NA, Gruss P, Identification of a novel mouse Iroquois homeobox gene, Irx5, and chromosomal localisation of all members of the mouse Iroquois gene family. Dev Dyn. 2000 May;218(1):160-74
1	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
3*	J:67359 Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG, Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar;21(5):1730-6
2	J:322321 Catela C, Chen Y, Weng Y, Wen K, Kratsios P, Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766
6	J:103461 Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH, The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development. Dev Biol. 2005 Nov 1;287(1):48-60
1*	J:64882 Christoffels VM, Habets PE, Franco D, Campione M, de Jong F, Lamers WH, Bao ZZ, Palmer S, Biben C, Harvey RP, Moorman AF, Chamber formation and morphogenesis in the developing mammalian heart [published erratum appears in Dev Biol 2000 Sep 1;225(1):266]. Dev Biol. 2000 Jul 15;223(2):266-78
8*	J:64020 Christoffels VM, Keijser AG, Houweling AC, Clout DE, Moorman AF, Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Dev Biol. 2000 Aug 15;224(2):263-74
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
7*	J:61328 Cohen DR, Cheng CW, Cheng SH, Hui C, Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
4	J:115194 Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG, The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21;123(2):347-58
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
7	J:265538 Fu A, Oberholtzer SM, Bagheri-Fam S, Rastetter RH, Holdreith C, Caceres VL, John SV, Shaw SA, Krentz KJ, Zhang X, Hui CC, Wilhelm D, Jorgensen JS, Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries. PLoS Genet. 2018 Aug;14(8):e1007488
1	J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405
3	J:189007 Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG, Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov;139(21):4007-19
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3	J:119151 Grego-Bessa J, Luna-Zurita L, del Monte G, Bolos V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Perez-Pomares JM, de la Pompa JL, Notch signaling is essential for ventricular chamber development. Dev Cell. 2007 Mar;12(3):415-29
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
15*	J:71423 Houweling AC, Dildrop R, Peters T, Mummenhoff J, Moorman AF, Ruther U, Christoffels VM, Gene and cluster-specific expression of the Iroquois family members during mouse development. Mech Dev. 2001 Sep;107(1-2):169-74
1	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
2	J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915
1	J:139700 Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep;135(17):2905-16
1	J:239871 Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I, Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15;142(22):3954-63
2	J:173702 Kim B, Kim Y, Cooke PS, Ruther U, Jorgensen JS, The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice. Biol Reprod. 2011 May;84(5):1024-32
6*	J:168037 Kim B, Kim Y, Sakuma R, Hui CC, Ruther U, Jorgensen JS, Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol. 2011 Jan 15;349(2):417-26
2	J:86477 Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau BG, Hui CC, The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov;23(22):8216-25
9*	J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
1	J:343468 Li Y, Xiao D, Chen H, Zheng XFS, Xiang M, Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms. iScience. 2023 Dec 15;26(12):108544
4	J:308430 Lopez-Gonzalez L, Alonso A, Garcia-Calero E, de Puelles E, Puelles L, Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling. Front Cell Dev Biol. 2021;9:676121
2	J:165329 Luna-Zurita L, Prados B, Grego-Bessa J, Luxan G, del Monte G, Benguria A, Adams RH, Perez-Pomares JM, de la Pompa JL, Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 2010 Oct 1;120(10):3493-507
1	J:195070 Luxan G, Casanova JC, Martinez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-Garcia JL, Fernandez-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibanez B, Medrano C, Garcia-Pavia P, Gimeno JR,Monserrat L, Jimenez-Borreguero LJ, de la Pompa JL, Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med. 2013 Feb;19(2):193-201
1	J:313967 Mass E, Wachten D, Aschenbrenner AC, Voelzmann A, Hoch M, Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Dev Cell. 2014 Mar 31;28(6):711-26
1	J:243618 McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM, Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature. 2017 Jan 12;541(7636):182-187
4*	J:163793 McDonald LA, Gerrelli D, Fok Y, Hurst LD, Tickle C, Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos. J Anat. 2010 Jun;216(6):683-91
1*	J:130227 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI, Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan;8(2):124-39
2*	J:66436 Moorman AF, Houweling AC, de Boer PA, Christoffels VM, Sensitive nonradioactive detection of mRNA in tissue sections. Novel application of the whole-mount in situ hybridization protocol. J Histochem Cytochem. 2001 Jan;49(1):1-8
4	J:261627 Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, Takumi T, Yokota Y, Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5. Mol Cell Biol. 2018 Feb 20;
1*	J:71977 Mummenhoff J, Houweling AC, Peters T, Christoffels VM, Ruther U, Expression of Irx6 during mouse morphogenesis. Mech Dev. 2001 May;103(1-2):193-5
1*	J:333713 Narwidina A, Miyazaki A, Iwata K, Kurogoushi R, Sugimoto A, Kudo Y, Kawarabayashi K, Yamakawa Y, Akazawa Y, Kitamura T, Nakagawa H, Yamaguchi-Ueda K, Hasegawa T, Yoshizaki K, Fukumoto S, Yamamoto A, Ishimaru N, Iwasaki T, Iwamoto T, Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochem Biophys Res Commun. 2023 Apr 2;650:47-54
1	J:266266 Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S, Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol. 2018 Oct 15;442(2):236-248
1*	J:67816 Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dolle P, Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development. 2001 Apr;128(7):1019-31
1	J:263215 Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R, HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell. 2014 Nov 10;31(3):345-357
1	J:197985 Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K, ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
1	J:264118 Papoutsi T, Luna-Zurita L, Prados B, Zaffran S, de la Pompa JL, Bmp2 and Notch cooperate to pattern the embryonic endocardium. Development. 2018 Jul 2;145(13):dev163378
1	J:311888 Prados B, Gomez-Apinaniz P, Papoutsi T, Luxan G, Zaffran S, Perez-Pomares JM, de la Pompa JL, Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity. Cell Death Dis. 2018 Mar 14;9(3):399
1	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
2	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
1	J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
1*	J:125316 Reggiani L, Raciti D, Airik R, Kispert A, Brandli AW, The prepattern transcription factor Irx3 directs nephron segment identity. Genes Dev. 2007 Sep 15;21(18):2358-70
1	J:152116 Remme CA, Verkerk AO, Hoogaars WM, Aanhaanen WT, Scicluna BP, Annink C, van den Hoff MJ, Wilde AA, van Veen TA, Veldkamp MW, de Bakker JM, Christoffels VM, Bezzina CR, The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium. Basic Res Cardiol. 2009 Sep;104(5):511-22
1	J:342640 Sampath Kumar A, Tian L, Bolondi A, Hernandez AA, Stickels R, Kretzmer H, Murray E, Wittler L, Walther M, Barakat G, Haut L, Elkabetz Y, Macosko EZ, Guignard L, Chen F, Meissner A, Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nat Genet. 2023 Jul;55(7):1176-1185
1	J:309382 Sandireddy R, Cibi DM, Gupta P, Singh A, Tee N, Uemura A, Epstein JA, Singh MK, Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. JCI Insight. 2019 Aug 22;4(16)
2	J:236978 Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL, Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
4*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
4	J:313344 Son JE, Dou Z, Wanggou S, Chan J, Mo R, Li X, Huang X, Kim KH, Michaud JL, Hui CC, Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency. Sci Adv. 2021 Oct 29;7(44):eabh4503
1	J:350460 Soussi G, Girdziusaite A, Jhanwar S, Palacio V, Notaro M, Sheth R, Zeller R, Zuniga A, TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)
1*	J:189955 Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL, Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
1*	J:171106 Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T, Dynamic spatiotemporal gene expression in embryonic mouse thalamus. J Comp Neurol. 2011 Feb 15;519(3):528-43
1	J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:315981 Torregrosa-Carrion R, Pineiro-Sabaris R, Siguero-Alvarez M, Grego-Bessa J, Luna-Zurita L, Fernandes VS, MacGrogan D, Stainier DYR, de la Pompa JL, Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
1	J:291481 Wang L, Xie J, Zhang H, Tsang LH, Tsang SL, Braune EB, Lendahl U, Sham MH, Notch signalling regulates epibranchial placode patterning and segregation. Development. 2020 Feb 17;147(4):dev183665
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2	J:297542 Younes ST, Herrington B, In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma. PLoS One. 2020;15(11):e0242521
1	J:306263 Zhang YH, Xu M, Shi X, Sun XL, Mu W, Wu H, Wang J, Li S, Su P, Gong L, He M, Yao M, Wu QF, Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 2021 Apr 17;
2	J:206589 Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M, Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
2	J:211548 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17
1	J:213417 Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC, A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28;29(2):241-9