Gene Expression Literature Summary

• Symbol: Barhl1
• Name: BarH like homeobox 1
• ID: MGI:1859288

62 matching records from 62 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)							1	1	1		2		2	2	1	5	1		2		5
In situ RNA (section)		1	1		1	8	1	5	10	1	11	1	16	10	1	9	5	2	13		11
Immunohistochemistry (whole mount)											1				1	2
In situ RNA (whole mount)	1		1	3		4		4	2		1		2	6		3	2		2	1
In situ reporter (knock in)						1		1					2			3					4
RT-PCR								1	1		1		1	2							1
cDNA clones								1					1							2	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Barhl1  BarH like homeobox 1   (Synonyms: Dres115, MBH2)
Results	Reference
2	J:121107 Abraira VE, Hyun N, Tucker AF, Coling DE, Brown MC, Lu C, Hoffman GR, Goodrich LV, Changes in Sef levels influence auditory brainstem development and function. J Neurosci. 2007 Apr 18;27(16):4273-82
3	J:69624 Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY, Proprioceptor pathway development is dependent on math1. Neuron. 2001 May;30(2):411-22
1*	J:76815 Broccoli V, Colombo E, Cossu G, Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures. Mech Dev. 2002 Jun;114(1-2):219
4*	J:51411 Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E, Borsani G, Banfi S, Ballabio A, The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function. Hum Mol Genet. 1998 Dec;7(13):1997-2006
13*	J:62505 Bulfone A, Menguzzato E, Broccoli V, Marchitiello A, Gattuso C, Mariani M, Consalez GG, Martinez S, Ballabio A, Banfi S, Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Hum Mol Genet. 2000 May 22;9(9):1443-52
3	J:132646 Chellappa R, Li S, Pauley S, Jahan I, Jin K, Xiang M, Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system. Mol Cell Biol. 2008 Mar;28(6):1905-14
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
2*	J:103453 Denaxa M, Kyriakopoulou K, Theodorakis K, Trichas G, Vidaki M, Takeda Y, Watanabe K, Karagogeos D, The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneurons. Dev Biol. 2005 Dec 1;288(1):87-99
1	J:197162 Di Bonito M, Narita Y, Avallone B, Sequino L, Mancuso M, Andolfi G, Franze AM, Puelles L, Rijli FM, Studer M, Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem. PLoS Genet. 2013;9(2):e1003249
7	J:193244 Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AH, Eichmann A, Wellik D, Ducret S, Rijli FM, Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science. 2013 Jan 11;339(6116):204-7
4	J:137616 Di Meglio T, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chedotal A, Molecular mechanisms controlling midline crossing by precerebellar neurons. J Neurosci. 2008 Jun 18;28(25):6285-94
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:181907 Ding Q, Joshi PS, Xie ZH, Xiang M, Gan L, BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1566-71
1	J:253971 Dominici C, Rappeneau Q, Zelina P, Fouquet S, Chedotal A, Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins. Development. 2018 Jan 17;145(2):dev150375
1	J:119485 Friedel RH, Kerjan G, Rayburn H, Schuller U, Sotelo C, Tessier-Lavigne M, Chedotal A, Plexin-B2 controls the development of cerebellar granule cells. J Neurosci. 2007 Apr 4;27(14):3921-32
3*	J:278498 Friocourt F, Kozulin P, Belle M, Suarez R, Di-Poi N, Richards LJ, Giacobini P, Chedotal A, Shared and differential features of Robo3 expression pattern in amniotes. J Comp Neurol. 2019 Aug 15;527(12):2009-2029
4	J:139385 Geisen MJ, Di Meglio T, Pasqualetti M, Ducret S, Brunet JF, Chedotal A, Rijli FM, Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol. 2008 Jun 10;6(6):e142
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:207650 Ha TJ, Swanson DJ, Kirova R, Yeung J, Choi K, Tong Y, Chesler EJ, Goldowitz D, Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum. Eur J Neurosci. 2012 Oct;36(7):2888-98
2	J:226611 Hillmer RE, Boisvert JP, Cucciare MJ, Dwinell MB, Joksimovic M, Generation and characterization of mice harboring a conditional CXCL12 allele. Int J Dev Biol. 2015;59(4-6):205-9
1	J:184447 Hu J, Huang T, Li T, Guo Z, Cheng L, c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci. 2012 Apr 18;32(16):5362-73
5	J:163647 Kawauchi D, Muroyama Y, Sato T, Saito T, Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes. Dev Biol. 2010 Aug 15;344(2):1026-34
3	J:141952 Kawauchi D, Saito T, Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation. Dev Biol. 2008 Aug 9;322(2):345-354
2	J:169455 Kim D, Ackerman SL, The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons. J Neurosci. 2011 Feb 9;31(6):2167-79
1	J:169298 Klisch TJ, Xi Y, Flora A, Wang L, Li W, Zoghbi HY, In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3288-93
2*	J:319650 Kobayashi H, Saragai S, Naito A, Ichio K, Kawauchi D, Murakami F, Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons. Development. 2015 Jan 15;142(2):375-84
6	J:191198 Kopecky BJ, Jahan I, Fritzsch B, Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
2	J:352993 Krishnamurthy A, Lee AS, Bayin NS, Stephen DN, Nasef O, Lao Z, Joyner AL, Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival. Development. 2024 Jul 15;151(14):dev202502
2	J:175146 Kumbasar A, Plachez C, Gronostajski RM, Richards LJ, Litwack ED, Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei. J Comp Neurol. 2009 Mar 1;513(1):98-112
1	J:163240 Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, Okano HJ, Okano H, Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010 Aug 12;67(3):407-21
3*	J:107595 Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM, Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. 2005 Dec 22;48(6):933-47
1	J:89813 Lanuza GM, Gosgnach S, Pierani A, Jessell TM, Goulding M, Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004 May 13;42(3):375-86
6*	J:77122 Li S, Price SM, Cahill H, Ryugo DK, Shen MM, Xiang M, Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development. 2002 Jul;129(14):3523-32
9	J:96912 Li S, Qiu F, Xu A, Price SM, Xiang M, Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene. J Neurosci. 2004 Mar 24;24(12):3104-14
2*	J:120983 Li S, Xiang M, Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus. Dev Dyn. 2006 Aug;235(8):2260-5
4	J:143462 Liu Z, Li H, Hu X, Yu L, Liu H, Han R, Colella R, Mower GD, Chen Y, Qiu M, Control of precerebellar neuron development by Olig3 bHLH transcription factor. J Neurosci. 2008 Oct 1;28(40):10124-33
8	J:306314 Maheshwari U, Kraus D, Vilain N, Holwerda SJB, Cankovic V, Maiorano NA, Kohler H, Satoh D, Sigrist M, Arber S, Kratochwil CF, Di Meglio T, Ducret S, Rijli FM, Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets. Cell Rep. 2020 Jun 16;31(11):107767
8	J:293331 Martinez-Chavez E, Scheerer C, Wizenmann A, Blaess S, The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration. Development. 2018 Dec 17;145(24):dev166033
4	J:348685 Masuda A, Nishida K, Ajima R, Saga Y, Bakhtan M, Klar A, Hirata T, Zhu Y, A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types. Sci Adv. 2024 May 24;10(21):eadk2149
1	J:180393 Miletich I, Yu WY, Zhang R, Yang K, Caixeta de Andrade S, Pereira SF, Ohazama A, Mock OB, Buchner G, Sealby J, Webster Z, Zhao M, Bei M, Sharpe PT, Developmental stalling and organ-autonomous regulation of morphogenesis. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19270-5
2*	J:89191 Mo Z, Li S, Yang X, Xiang M, Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. Development. 2004 Apr;131(7):1607-18
1	J:253980 Moreno-Bravo JA, Roig Puiggros S, Blockus H, Dominici C, Zelina P, Mehlen P, Chedotal A, Commissural neurons transgress the CNS/PNS boundary in absence of ventricular zone-derived netrin 1. Development. 2018 Jan 17;145(2):dev159400
3	J:171288 Nishida K, Nakayama K, Yoshimura S, Murakami F, Role of Neph2 in pontine nuclei formation in the developing hindbrain. Mol Cell Neurosci. 2011 Mar;46(3):662-70
2	J:283382 Qin L, Ahn KJ, Wine Lee L, de Charleroy C Jr, Crenshaw EB 3rd, Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip. PLoS One. 2019;14(12):e0226602
1*	J:338811 Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G, Suo S, Peng G, Three-dimensional molecular architecture of mouse organogenesis. Nat Commun. 2023 Jul 31;14(1):4599
7*	J:106097 Rachidi M, Lopes C, Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning. Int J Dev Neurosci. 2006 Feb;24(1):35-44
2*	J:242973 Ravindran E, Hu H, Yuzwa SA, Hernandez-Miranda LR, Kraemer N, Ninnemann O, Musante L, Boltshauser E, Schindler D, Hubner A, Reinecker HC, Ropers HH, Birchmeier C, Miller FD, Wienker TF, Hubner C, Kaindl AM, Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation. PLoS Genet. 2017 Apr;13(4):e1006746
1	J:158918 Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chedotal A, Genetic dissection of the function of hindbrain axonal commissures. PLoS Biol. 2010;8(3):e1000325
2*	J:222006 Riyadh MA, Shinmyo Y, Ohta K, Tanaka H, Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons. Biochem Biophys Res Commun. 2014 Jun 20;449(1):169-74
1	J:155932 Rose MF, Ahmad KA, Thaller C, Zoghbi HY, Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22462-7
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:143526 Storm R, Cholewa-Waclaw J, Reuter K, Brohl D, Sieber M, Treier M, Muller T, Birchmeier C, The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development. 2009 Jan;136(2):295-305
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:345248 Tran HN, Nguyen QH, Jeong Y, Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1	J:326661 Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y, Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:218606 Zelina P, Blockus H, Zagar Y, Peres A, Friocourt F, Wu Z, Rama N, Fouquet C, Hohenester E, Tessier-Lavigne M, Schweitzer J, Roest Crollius H, Chedotal A, Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution. Neuron. 2014 Dec 17;84(6):1258-72
1	J:306263 Zhang YH, Xu M, Shi X, Sun XL, Mu W, Wu H, Wang J, Li S, Su P, Gong L, He M, Yao M, Wu QF, Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 2021 Apr 17;
8	J:294199 Zhu Y, Hirata T, Mackay F, Murakami F, Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation. Sci Rep. 2020 Jul 16;10(1):11830
6	J:149543 Zhu Y, Matsumoto T, Mikami S, Nagasawa T, Murakami F, SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation. Development. 2009 Jun;136(11):1919-28