Gene Expression Literature Summary

• Symbol: Dll4
• Name: delta like canonical Notch ligand 4
• ID: MGI:1859388

190 matching records from 190 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1.5	E2.5	E3.5	E4	E4.5	E5	E5.5	E6	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)								1				2	3	3	10	1	11	1	11		5		6		6		5		5		3		3	1	1	9
In situ RNA (section)											1		5	6	7		11	2	10	1	10		9		11		7		6		3		7		6	10
Immunohistochemistry (whole mount)					1	1	1	2	1				1	1	3	1	1	1					1	1	3		2		1				1			7
In situ RNA (whole mount)											2	1	7	2	6		4	1		1	1	1			1		1								3	2
In situ reporter (knock in)												2	5	4	6	1	7		2		3		1		2		1		1		2		2			6
Northern blot										1								1								1				1						2
Western blot																							1				1								1	1
RT-PCR	1	1	2	2	1	1		1					4	5	15		8		7	1	8	2	10		7	2	6	1	4	1	4	1	7		3	27
cDNA clones																														1						1
RNase protection																																				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dll4  delta like canonical Notch ligand 4   (Synonyms: Delta4)
Results	Reference
1*	J:245710 Adam MG, Berger C, Feldner A, Yang WJ, Wustehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A, Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 2013 Nov 08;113(11):1206-18
2	J:288357 Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I, Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat Commun. 2014 Jul 29;5:4552
4	J:237925 Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, Marty-Santos L, Fu S, Dor Y, Cleaver O, Vascular development in the vertebrate pancreas. Dev Biol. 2016 Dec 01;420(1):67-78
2*	J:316418 Azzoni E, Frontera V, Anselmi G, Rode C, James C, Deltcheva EM, Demian AS, Brown J, Barone C, Patelli A, Harman JR, Nicholls M, Conway SJ, Morrissey E, Jacobsen SEW, Sparrow DB, Harris AL, Enver T, de Bruijn MFTR, The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition. Cell Rep. 2021 Dec 14;37(11):110103
10*	J:99531 Benedito R, Duarte A, Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns. 2005 Aug;5(6):750-5
5	J:145172 Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A, Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol. 2008;8:117
1	J:229394 Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova TV, DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest. 2015 Dec;125(12):4572-86
3	J:249355 Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bauerle T, Hartwig J, Baumgart J, Kruger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH, Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 2017 Jun 28;8:15922
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:163537 Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B, Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 2010 Aug 20;10(1):89
1	J:76133 Brennan J, Karl J, Capel B, Divergent Vascular Mechanisms Downstream of Sry Establish the Arterial System in the XY Gonad. Dev Biol. 2002 Apr 15;244(2):418-28
5	J:310741 Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML, Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22;31(6):707-21
1	J:186083 Calderon L, Boehm T, Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell. 2012 Mar 30;149(1):159-72
7	J:338402 Cao X, Li T, Xu B, Ding K, Li W, Shen B, Chu M, Zhu D, Rui L, Shang Z, Li X, Wang Y, Zheng S, Alitalo K, Liu G, Tang J, Kubota Y, He Y, Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):e323-e338
1	J:196361 Cappellari O, Benedetti S, Innocenzi A, Tedesco FS, Moreno-Fortuny A, Ugarte G, Lampugnani MG, Messina G, Cossu G, Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013 Mar 25;24(6):586-99
2	J:108618 Carson C, Murdoch B, Roskams AJ, Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium. Dev Dyn. 2006 Jun;235(6):1678-88
2	J:161794 Catela C, Kratsios P, Hede M, Lang F, Rosenthal N, Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis. Dev Dyn. 2010 Aug;239(8):2149-60
2	J:151951 Chen H, Ko G, Zatti A, Di Giacomo G, Liu L, Raiteri E, Perucco E, Collesi C, Min W, Zeiss C, De Camilli P, Cremona O, Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43
3	J:97734 Chen L, Al-Awqati Q, Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol. 2005 May;288(5):F939-52
1	J:353282 Chen R, Fan R, Chen F, Govindasamy N, Brinkmann H, Stehling M, Adams RH, Jeong HW, Bedzhov I, Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling. Cell Stem Cell. 2024 Jul 18;
1	J:205488 Chin SS, Romano RA, Nagarajan P, Sinha S, Garrett-Sinha LA, Aberrant epidermal differentiation and disrupted DeltaNp63/Notch regulatory axis in Ets1 transgenic mice. Biol Open. 2013;2(12):1336-45
1	J:267108 Cho E, Mysliwiec MR, Carlson CD, Ansari A, Schwartz RJ, Lee Y, Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. J Biol Chem. 2018 Jul 27;293(30):11659-11673
5	J:174608 Chong DC, Koo Y, Xu K, Fu S, Cleaver O, Stepwise arteriovenous fate acquisition during mammalian vasculogenesis. Dev Dyn. 2011 Sep;240(9):2153-65
1	J:239442 Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y, Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. Elife. 2016 Dec 22;5:e21032
1	J:169692 Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL, Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011;11:12
1	J:163848 Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E, The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell. 2010 Jun 15;18(6):938-49
2	J:206194 Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E, Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609
4*	J:93160 Cormier S, Vandormael-Pournin S, Babinet C, Cohen-Tannoudji M, Developmental expression of the Notch signaling pathway genes during mouse preimplantation development. Gene Expr Patterns. 2004 Oct;4(6):713-7
2	J:162821 Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC, Rossant J, Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms. Blood. 2010 Jul 29;116(4):653-60
1	J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
2	J:271384 D'Amato G, Luxan G, del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL, Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol. 2016 Jan;18(1):7-20
1	J:334548 Davies EM, Gurung R, Le KQ, Roan KTT, Harvey RP, Mitchell GM, Schwarz Q, Mitchell CA, PI(4,5)P(2)-dependent regulation of endothelial tip cell specification contributes to angiogenesis. Sci Adv. 2023 Mar 31;9(13):eadd6911
1*	J:194470 Davis RB, Curtis CD, Griffin CT, BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013 Mar;140(6):1272-81
7	J:297083 De Zoysa P, Liu J, Toubat O, Choi J, Moon A, Gill PS, Duarte A, Sucov HM, Kumar SR, Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression. Development. 2020 Sep 11;147(17):dev185249
3	J:308916 De Zoysa P, Toubat O, Harvey D, Choi J, Kumar SR, Murine Model of Cardiac Defects Observed in Adams-Oliver Syndrome Driven by Delta-Like Ligand-4 Haploinsufficiency. Stem Cells Dev. 2021 Jun 15;30(12):611-621
4	J:330268 De Zoysa P, Toubat O, Harvey DC, Yi C, Liu J, Cavallero S, Hong YK, Sucov HM, Kumar SR, Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells. J Cell Mol Med. 2022 Oct;26(20):5181-5194
2	J:128001 Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk DI, Li S, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, Richardson WD, A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development. 2007 Oct;134(19):3427-36
5	J:178290 del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Perez-Pomares JM, de la Pompa JL, Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res. 2011 Apr 1;108(7):824-36
2*	J:124179 Del Monte G, Grego-Bessa J, Gonzalez-Rajal A, Bolos V, De La Pompa JL, Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop. Dev Dyn. 2007 Sep;236(9):2594-614
9	J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445
1	J:247084 Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC, FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014 Jul 07;115(2):238-251
1	J:159860 Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ, RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development. 2010 May;137(9):1461-71
6*	J:93157 Duarte A, Hirashima M, Benedito R, Trindade A, Diniz P, Bekman E, Costa L, Henrique D, Rossant J, Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004 Oct 15;18(20):2474-8
2	J:355651 El Azhar Y, Schulthess P, van Oostrom MJ, Weterings SDC, Meijer WHM, Tsuchida-Straeten N, Thomas WM, Bauer M, Sonnen KF, Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
3	J:264144 Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ, A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7:e34110
1	J:345073 Eley L, Richardson RV, Alqahtani A, Chaudhry B, Henderson DJ, eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling. Dis Model Mech. 2024 Jan 1;17(1)
1	J:228701 Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, Ruhrberg C, NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep. 2015 Jun 16;11(10):1577-90
1*	J:142081 Fiorini E, Ferrero I, Merck E, Favre S, Pierres M, Luther SA, MacDonald HR, Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. J Immunol. 2008 Dec 15;181(12):8199-203
1	J:102852 Francis JC, Radtke F, Logan MP, Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn. 2005 Dec;234(4):1006-15
1	J:240621 Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F, Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2016;9:145
2	J:237449 Francius C, Ravassard P, Hidalgo-Figueroa M, Mallet J, Clotman F, Nardelli J, Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord. Dev Neurobiol. 2015 Jul;75(7):721-37
1	J:140104 Franco CA, Mericskay M, Parlakian A, Gary-Bobo G, Gao-Li J, Paulin D, Gustafsson E, Li Z, Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell. 2008 Sep;15(3):448-61
2	J:94740 Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD, Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54
1	J:227634 Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, Lopez-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A, Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun. 2015;6:8510
2	J:317800 Garcia-Pascual CM, Ferrero H, Zimmermann RC, Simon C, Pellicer A, Gomez R, Inhibition of Delta-like 4 mediated signaling induces abortion in mice due to deregulation of decidual angiogenesis. Placenta. 2014 Jul;35(7):501-8
5*	J:199123 Gasperowicz M, Rai A, Cross JC, Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta. Gene Expr Patterns. 2013 Oct;13(7):249-54
1*	J:87736 Gazit R, Krizhanovsky V, Ben-Arie N, Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development. 2004 Feb;131(4):903-13
1	J:308918 Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe JD, Mikelis CM, Hla T, Srinivasan RS, S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020 Jul 23;5(14)
1	J:168516 Gordon FE, Nutt CL, Cheunsuchon P, Nakayama Y, Provencher KA, Rice KA, Zhou Y, Zhang X, Klibanski A, Increased expression of angiogenic genes in the brains of mouse meg3-null embryos. Endocrinology. 2010 Jun;151(6):2443-52
6	J:316177 Govindasamy N, Long H, Jeong HW, Raman R, Ozcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I, 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Dev Cell. 2021 Dec 6;56(23):3276-3287.e8
2	J:352089 Grammer C, Komorowska JA, Swann JB, Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
2	J:119151 Grego-Bessa J, Luna-Zurita L, del Monte G, Bolos V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Perez-Pomares JM, de la Pompa JL, Notch signaling is essential for ventricular chamber development. Dev Cell. 2007 Mar;12(3):415-29
6	J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:251433 Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW, The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363
1	J:185205 Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M, Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012 May;8(5):e1002728
2	J:215459 Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T, Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
9	J:258489 Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD, A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open. 2018 Feb 8;:bio026799
1	J:118039 High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA, An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest. 2007 Feb 1;117(2):353-363
1	J:189213 Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y, Iruela-Arispe ML, Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 2012 Dec;139(23):4449-60
5	J:325252 Hou S, Li Z, Dong J, Gao Y, Chang Z, Ding X, Li S, Li Y, Zeng Y, Xin Q, Wang B, Ni Y, Ning X, Hu Y, Fan X, Hou Y, Li X, Wen L, Zhou B, Liu B, Tang F, Lan Y, Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Cell Res. 2022 Apr;32(4):333-348
1	J:152840 Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, Shen CK, Yan YT, Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 2009 Sep 3;583(17):2765-71
1	J:317063 Huang X, Zhao K, Jiang M, Qiu D, Zhou J, Yang Z, The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms. J Biol Chem. 2021 Nov 25;298(1):101449
1	J:296854 Hultgren NW, Fang JS, Ziegler ME, Ramirez RN, Phan DTT, Hatch MMS, Welch-Reardon KM, Paniagua AE, Kim LS, Shon NN, Williams DS, Mortazavi A, Hughes CCW, Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. Nat Commun. 2020 Oct 26;11(1):5400
2	J:124645 Itoi M, Tsukamoto N, Yoshida H, Amagai T, Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol. 2007 Aug;19(8):953-64
1	J:137628 Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A, Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development. 2008 Jul;135(14):2479-88
2	J:320186 Kalisch-Smith JI, Morris EC, Strevens MAA, Redpath AN, Klaourakis K, Szumska D, Outhwaite JE, Sun X, Vieira JM, Smart N, De Val S, Riley PR, Sparrow DB, Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects. Front Genet. 2021;12:806136
1	J:193861 Kang K, Lee D, Hong S, Park SG, Song MR, The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord. J Biol Chem. 2013 Jan 25;288(4):2580-92
1	J:271625 Kim KH, Nakaoka Y, Augustin HG, Koh GY, Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly. Cell Rep. 2018 May 22;23(8):2455-2466
1	J:180905 Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA, Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug;138(15):3225-33
1	J:144857 Kim YH, Hu H, Guevara-Gallardo S, Lam MT, Fong SY, Wang RA, Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development. 2008 Nov;135(22):3755-64
2	J:101173 Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, Kong YY, Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development. 2005 Aug;132(15):3459-70
3	J:62571 Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP, Gallahan D, Closson V, Kitajewski J, Callahan R, Smith GH, Stark KL, Gridley T, Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 2000 Jun 1;14(11):1343-52
1*	J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
2	J:268317 Kumar DL, DeFalco T, A perivascular niche for multipotent progenitors in the fetal testis. Nat Commun. 2018 Oct 30;9(1):4519
4*	J:321979 Kurz J, Weiss AC, Thiesler H, Qasrawi F, Deuper L, Kaur J, Rudat C, Ludtke TH, Wojahn I, Hildebrandt H, Trowe MO, Kispert A, Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
1*	J:175663 Laforest B, Andelfinger G, Nemer M, Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011 Jul 1;121(7):2876-87
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
1	J:239835 Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG, Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471
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