Gene Expression Literature Summary

• Symbol: Pdgfc
• Name: platelet-derived growth factor, C polypeptide
• ID: MGI:1859631

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)						1		1		1		2		1		1						1
In situ RNA (section)				1		2		3	1	6		4	1	5		1			2	1	1	1
In situ RNA (whole mount)			3	1		1		2		1				2							2
In situ reporter (knock in)			3	1		1		1				1		1		1		2	1			1
Northern blot				2																		2
Western blot					1		1	1	1				1				1					2
RT-PCR	1	1	1	1		3		1			1	2			1	1						2
cDNA clones																					1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pdgfc  platelet-derived growth factor, C polypeptide   (Synonyms: 1110064L01Rik, PDGF-C)
Results	Reference
10*	J:73808 Aase K, Abramsson A, Karlsson L, Betsholtz C, Eriksson U, Expression analysis of PDGF-C in adult and developing mouse tissues. Mech Dev. 2002 Jan;110(1-2):187-91
1	J:205009 Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C, Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol Cell Biol. 2013 Oct;33(20):4030-40
3	J:232500 Andrae J, Gouveia L, Gallini R, He L, Fredriksson L, Nilsson I, Johansson BR, Eriksson U, Betsholtz C, A role for PDGF-C/PDGFRalpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex. Biol Open. 2016;5(4):461-74
6*	J:196196 Awuah PK, Nejak-Bowen KN, Monga SP, Role and Regulation of PDGFRalpha Signaling in Liver Development and Regeneration. Am J Pathol. 2013 May;182(5):1648-58
2	J:82564 Brennan J, Tilmann C, Capel B, Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 2003 Mar 15;17(6):800-10
1	J:339854 Chen SY, Liu FC, The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung. Development. 2023 Aug 15;150(16):dev201827
1	J:308882 Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA, Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme. Development. 2021 Jul 15;148(14):dev199448
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:93954 Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY, Soriano P, Betsholtz C, Hart TC, Marazita ML, Field LL, Tam PP, Nagy A, A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004 Oct;36(10):1111-6
9*	J:64341 Ding H, Wu X, Kim I, Tam PP, Koh GY, Nagy A, The mouse pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mech Dev. 2000 Sep;96(2):209-13
1	J:93392 Fredriksson L, Li H, Fieber C, Li X, Eriksson U, Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 2004 Sep 29;23(19):3793-802
7*	J:327413 Gillnas S, Gallini R, He L, Betsholtz C, Andrae J, Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRalpha signalling in cerebellar development. Biol Open. 2022 Aug 15;11(8):bio059431
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:166721 He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y, Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010 Dec;239(12):3235-46
2	J:202450 He F, Soriano P, A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet. 2013 Sep;9(9):e1003851
2	J:245766 He F, Soriano P, Dysregulated PDGFRalpha signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017 Nov 01;144(21):4026-4036
1	J:341969 Jacob T, Annusver K, Czarnewski P, Dalessandri T, Kalk C, Levra Levron C, Campama Sanz N, Kastriti ME, Mikkola ML, Rendl M, Lichtenberger BM, Donati G, Bjorklund AK, Kasper M, Molecular and spatial landmarks of early mouse skin development. Dev Cell. 2023 Oct 23;58(20):2140-2162.e5
4	J:135147 Kurahashi M, Niwa Y, Cheng J, Ohsaki Y, Fujita A, Goto H, Fujimoto T, Torihashi S, Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut. Neurogastroenterol Motil. 2008 May;20(5):521-31
1	J:62052 Li X, Ponten A, Aase K, Karlsson L, Abramsson A, Uutela M, Backstrom G, Hellstrom M, Bostrom H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U, PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
2	J:296151 Liu J, Chanumolu SK, White KM, Albahrani M, Otu HH, Nawshad A, Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
1*	J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
1	J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
1	J:281436 Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH, RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nat Commun. 2019 Nov 11;10(1):5116
1	J:165035 Niklasson M, Bergstrom T, Zhang XQ, Gustafsdottir SM, Sjogren M, Edqvist PH, Vennstrom B, Forsberg M, Forsberg-Nilsson K, Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells. Exp Cell Res. 2010 Oct 15;316(17):2779-89
4	J:146617 Olson LE, Soriano P, Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell. 2009 Feb;16(2):303-13
1	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
2	J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1	J:134482 Teng L, Mundell NA, Frist AY, Wang Q, Labosky PA, Requirement for Foxd3 in the maintenance of neural crest progenitors. Development. 2008 May;135(9):1615-24
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3	J:283457 Uijtdewilligen PJE, Versteeg EM, van de Westerlo EMA, van der Vlag J, Daamen WF, van Kuppevelt TH, Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Biomed Res Int. 2018;2018:9873471
1*	J:184925 Wang Y, Serra R, PDGF mediates TGFbeta-induced migration during development of the spinous process. Dev Biol. 2012 May 1;365(1):110-7
2	J:205063 Wiradjaja F, Cottle DL, Jones L, Smyth I, Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice. Dis Model Mech. 2013 Nov;6(6):1426-33
1	J:128709 Wu X, Ding H, Generation of conditional knockout alleles for PDGF-C. Genesis. 2007 Oct;45(10):653-7
4*	J:257668 Wu X, Liu W, Ding H, A Pdgf-c(CreERT2) knock-in mouse model for tracing PDGF-C cell lineages during development. Genesis. 2018 Feb;56(2)
2*	J:114601 Zhuo Y, Hoyle GW, Shan B, Levy DR, Lasky JA, Over-expression of PDGF-C using a lung specific promoter results in abnormal lung development. Transgenic Res. 2006 Oct;15(5):543-55