Symbol Name ID |
Msgn1
mesogenin 1 MGI:1860483 |
Age | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12.5 | E13.5 | E14.5 | E15.5 | E17.5 | E18.5 | E | P |
In situ RNA (section) | 1 | 1 | 2 | 2 | 4 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | ||||
In situ RNA (whole mount) | 1 | 1 | 4 | 4 | 9 | 7 | 9 | 1 | 5 | 1 | 3 | 1 | 3 | 1 | 1 | 4 | |||
In situ reporter (knock in) | 1 | ||||||||||||||||||
RT-PCR | 1 | 1 | |||||||||||||||||
cDNA clones | 1 |
Msgn1 mesogenin 1 (Synonyms: Msgn) | |
Results | Reference |
3* | J:272567 Aires R, de Lemos L, Novoa A, Jurberg AD, Mascrez B, Duboule D, Mallo M, Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes. Dev Cell. 2019 Feb 11;48(3):383-395.e8 |
2 | J:313582 Anderson MJ, Magidson V, Kageyama R, Lewandoski M, Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function. Elife. 2020 Nov 19;9:e55608 |
5 | J:232560 Anderson MJ, Schimmang T, Lewandoski M, An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016 May;12(5):e1006018 |
1 | J:229949 Anderson MJ, Southon E, Tessarollo L, Lewandoski M, Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis. 2016 Feb;54(2):91-8 |
1 | J:132361 Aulehla A, Wiegraebe W, Baubet V, Wahl MB, Deng C, Taketo M, Lewandoski M, Pourquie O, A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol. 2008 Feb;10(2):186-93 |
1* | J:245730 Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L, Pourquie O, The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818 |
1 | J:72325 Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R, Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev. 2001 Oct 15;15(20):2642-7 |
1 | J:190545 Boulet AM, Capecchi MR, Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45 |
2 | J:299537 Boylan M, Anderson MJ, Ornitz DM, Lewandoski M, The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. Development. 2020 Oct 19;147(21):dev189506 |
1 | J:163977 Bryja V, Andersson ER, Schambony A, Esner M, Bryjova L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E, The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell. 2009 Feb;20(3):924-36 |
1 | J:324925 Campbell GP, Farkas DR, Chapman DL, Ectopic expression of T in the paraxial mesoderm disrupts somite maturation in the mouse. Dev Biol. 2022 May;485:37-49 |
1* | J:223069 Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquie O, Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Sep;33(9):962-9 |
4 | J:205649 Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP, The Wnt3a/beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011;2:390 |
4 | J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615 |
1 | J:330342 Falk HJ, Tomita T, Monke G, McDole K, Aulehla A, Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation. Development. 2022 Jul 1;149(13):dev200083 |
2 | J:328993 Genuth NR, Shi Z, Kunimoto K, Hung V, Xu AF, Kerr CH, Tiu GC, Oses-Prieto JA, Salomon-Shulman REA, Axelrod JD, Burlingame AL, Loh KM, Barna M, A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Nat Commun. 2022 Sep 19;13(1):5491 |
5* | J:137643 Gomez C, Ozbudak EM, Wunderlich J, Baumann D, Lewis J, Pourquie O, Control of segment number in vertebrate embryos. Nature. 2008 Jul 17;454(7202):335-9 |
3* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1 | J:291438 Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP, Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15712-15723 |
1 | J:216160 Jurberg AD, Aires R, Novoa A, Rowland JE, Mallo M, Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol. 2014 Oct 15;394(2):253-63 |
1 | J:71693 Kume T, Jiang H, Topczewska JM, Hogan BL, The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82 |
1* | J:329046 Li B, Brusman L, Dahlka J, Niswander LA, TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration. Development. 2022 Sep 1;149(17):dev200442 |
1 | J:310041 Mariani L, Guo X, Menezes NA, Drozd AM, Cakal SD, Wang Q, Ferretti E, A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021 Aug 26;12(1):5136 |
8* | J:185807 Nowotschin S, Ferrer-Vaquer A, Concepcion D, Papaioannou VE, Hadjantonakis AK, Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo. Dev Biol. 2012 Jul 1;367(1):1-14 |
1 | J:139150 Oginuma M, Niwa Y, Chapman DL, Saga Y, Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development. 2008 Aug;135(15):2555-62 |
1 | J:154904 Savory JG, Bouchard N, Pierre V, Rijli FM, De Repentigny Y, Kothary R, Lohnes D, Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110 |
1 | J:243030 Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A, NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development. PLoS One. 2015;10(8):e0136566 |
1 | J:278240 Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, Kawakami Y, Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. Development. 2019 Jul 15;146(14):dev177659 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
1 | J:146397 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y, GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75 |
9* | J:129900 Wittler L, Shin EH, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG, Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep. 2007 Aug;8(8):784-9 |
8* | J:62914 Yoon JK, Moon RT, Wold B, The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91 |
2 | J:66514 Yoon JK, Wold B, The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev. 2000 Dec 15;14(24):3204-14 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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