Gene Expression Literature Summary

• Symbol: Ptbp2
• Name: polypyrimidine tract binding protein 2
• ID: MGI:1860489

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)	1	1								2	1		1			2	3
In situ RNA (section)		1				3		3		3			1			1	3
In situ RNA (whole mount)				1
In situ reporter (knock in)																1	1
Northern blot															1		2
Western blot					1	1	1	1	1	2	1	1	2		1	3	10
RT-PCR						1	1	2		1			1	1	1	2	7
cDNA clones			1			1											2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ptbp2  polypyrimidine tract binding protein 2   (Synonyms: brPTB)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4*	J:265269 Dhananjaya D, Hung KY, Tarn WY, RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018 Jun 15;38(12)
2	J:326362 Feng S, Li J, Wen H, Liu K, Gui Y, Wen Y, Wang X, Yuan S, hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells. Nat Commun. 2022 Jun 23;13(1):3588
2*	J:142671 Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA, A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20333-8
1	J:234106 Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z, NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 2016;5:e14264
4	J:207976 Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL, The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
8	J:185949 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB, Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
4*	J:68159 Lillevali K, Kulla A, Ord T, Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mech Dev. 2001 Mar;101(1-2):217-20
5	J:253164 Lin JC, Lu YH, Liu YR, Lin YJ, RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Sci Rep. 2016 Feb 9;6:20665
1	J:348634 Lin L, Zhao J, Kubota N, Li Z, Lam YL, Nguyen LP, Yang L, Pokharel SP, Blue SM, Yee BA, Chen R, Yeo GW, Chen CW, Chen L, Zheng S, Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. Neuron. 2024 Apr 22;
1	J:142220 Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN, microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008 Dec 1;22(23):3242-54
4	J:268025 Makeyev EV, Zhang J, Carrasco MA, Maniatis T, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007 Aug 3;27(3):435-48
3*	J:93141 Mattar P, Britz O, Johannes C, Nieto M, Ma L, Rebeyka A, Klenin N, Polleux F, Guillemot F, Schuurmans C, A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol. 2004 Sep 15;273(2):373-89
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
2*	J:193641 Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Banfi B, A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
6	J:62658 Polydorides AD, Okano HJ, Yang YY, Stefani G, Darnell RB, A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6350-5
3	J:337970 Salehi S, Zare A, Prezza G, Bader J, Schneider C, Fischer U, Meissner F, Mann M, Briese M, Sendtner M, Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Nat Commun. 2023 Jul 12;14(1):4158
4	J:213479 Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N, PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013 Aug;23(8):1824-35
2*	J:223915 Suckale J, Wendling O, Masjkur J, Jager M, Munster C, Anastassiadis K, Stewart AF, Solimena M, PTBP1 is required for embryonic development before gastrulation. PLoS One. 2011;6(2):e16992
1*	J:238787 Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguere V, Sonenberg N, Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016 Nov 01;113(44):12360-12367
1	J:163097 Thoren LA, Norgaard GA, Weischenfeldt J, Waage J, Jakobsen JS, Damgaard I, Bergstrom FC, Blom AM, Borup R, Bisgaard HC, Porse BT, UPF2 is a critical regulator of liver development, function and regeneration. PLoS One. 2010;5(7):e11650
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:239441 Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S, PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing. Cell Rep. 2016 Dec 06;17(10):2766-2775
1*	J:235839 Zagore LL, Grabinski SE, Sweet TJ, Hannigan MM, Sramkoski RM, Li Q, Licatalosi DD, RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development. Mol Cell Biol. 2015 Dec;35(23):4030-42
6	J:348672 Zheng S, Gray EE, Chawla G, Porse BT, O'Dell TJ, Black DL, PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nat Neurosci. 2012 Jan 15;15(3):381-8, S1
6	J:256883 Zhou J, Wang R, Zhang J, Zhu L, Liu W, Lu S, Chen P, Li H, Yin B, Yuan J, Qiang B, Shu P, Peng X, Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168