Gene Expression Literature Summary

• Symbol: Fgf21
• Name: fibroblast growth factor 21
• ID: MGI:1861377

28 matching records from 28 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E19	E19.5	E	P
In situ RNA (section)				1		3		2	1						3
In situ RNA (whole mount)	1	1	2	1	1	1	1
Northern blot															1
RT-PCR			3	2	2	2	1		1	1	3	1	1		16
cDNA clones														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf21  fibroblast growth factor 21
Results	Reference
3*	J:67307 Bachler M, Neubuser A, Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001 Feb;100(2):313-6
2	J:193325 Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
1	J:201436 Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M, Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
2	J:348105 Chen H, Luo S, Deng X, Li S, Mao Y, Yan J, Cheng Y, Liu X, Pan J, Huang H, Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
8*	J:231094 Du W, Prochazka J, Prochazkova M, Klein OD, Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 Mar;20(2):81-7
1	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:204192 Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F, A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci. 2013 Nov 6;33(45):17656-66
1*	J:76230 Hajihosseini MK, Heath JK, Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002 Apr;113(1):79-83
2	J:157252 Hiramatsu R, Harikae K, Tsunekawa N, Kurohmaru M, Matsuo I, Kanai Y, FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation. Development. 2010 Jan;137(2):303-12
1*	J:93162 Kurose H, Bito T, Adachi T, Shimizu M, Noji S, Ohuchi H, Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. Gene Expr Patterns. 2004 Oct;4(6):687-93
2	J:216177 Labialle S, Marty V, Bortolin-Cavaille ML, Hoareau-Osman M, Pradere JP, Valet P, Martin PG, Cavaille J, The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
1	J:224441 Lim GE, Albrecht T, Piske M, Sarai K, Lee JT, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD, 14-3-3zeta coordinates adipogenesis of visceral fat. Nat Commun. 2015;6:7671
2*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
3*	J:63008 Nishimura T, Nakatake Y, Konishi M, Itoh N, Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
2*	J:160766 Porntaveetus T, Oommen S, Sharpe PT, Ohazama A, Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. Gene Expr Patterns. 2010 Jun;10(4-5):193-8
2*	J:283695 Quesada-Lopez T, Gavalda-Navarro A, Moron-Ros S, Campderros L, Iglesias R, Giralt M, Villarroya F, GPR120 controls neonatal brown adipose tissue thermogenic induction. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E742-E750
2	J:176344 Ratzka A, Baron O, Grothe C, FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. PLoS One. 2011;6(8):e23564
2	J:119030 Spater D, Hill TP, O'sullivan RJ, Gruber M, Conner DA, Hartmann C, Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development. 2006 Aug;133(15):3039-49
1	J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8
2	J:269323 Vazquez P, Hernandez-Sanchez C, Escalona-Garrido C, Pereira L, Contreras C, Lopez M, Balsinde J, de Pablo F, Valverde AM, Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res. 2018 Dec;59(12):2308-2320
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:235644 Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K, Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355
3*	J:150712 Yaguchi Y, Yu T, Ahmed MU, Berry M, Mason I, Basson MA, Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Dev Dyn. 2009 Jun 19;238(8):2058-2072
1*	J:101025 Yaylaoglu MB, Titmus A, Visel A, Alvarez-Bolado G, Thaller C, Eichele G, Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn. 2005 Oct;234(2):371-86
1	J:311150 Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J, FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021 Aug 3;36(5):109481