Gene Expression Literature Summary

• Symbol: Gcm2
• Name: glial cells missing homolog 2
• ID: MGI:1861438

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19	P
Immunohistochemistry (section)														2	2	3	1		1	1										1
In situ RNA (section)												1		12		18	4	7	1	5		3	4		2	1		2		2
In situ RNA (whole mount)											1	1	1	11	1	5							2
In situ reporter (knock in)																										1
RT-PCR	1	1	1	1	2	1	2	1	1	1	1	2				2	1			1	1	1	1	1	2	1	1	1	1	6
cDNA clones																1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gcm2  glial cells missing homolog 2   (Synonyms: Gcm1-rs2)
Results	Reference
6	J:237523 Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR, Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016 Nov 01;143(21):4027-4037
1	J:54094 Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter P, Nait-Oumesmar B , Lazzarini RA, Murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Dev Dyn. 1999 Apr;214(4):303-11
2	J:304609 Caprio C, Lania G, Bilio M, Ferrentino R, Chen L, Baldini A, EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm. Dis Model Mech. 2021 Feb 19;:dmm.046789
1	J:161296 Chen L, Zhao P, Wells L, Amemiya CT, Condie BG, Manley NR, Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10555-60
10	J:217502 Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR, Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
1	J:164351 Corbeaux T, Hess I, Swann JB, Kanzler B, Haas-Assenbaum A, Boehm T, Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16613-8
1*	J:278363 Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC, MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5
1	J:162413 Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC, EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13414-9
3	J:187709 Gardiner JR, Jackson AL, Gordon J, Lickert H, Manley NR, Basson MA, Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development. 2012 Sep;139(18):3456-66
6*	J:69783 Gordon J, Bennett AR, Blackburn CC, Manley NR, Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Mech Dev. 2001 May;103(1-2):141-3
3	J:176247 Gordon J, Manley NR, Mechanisms of thymus organogenesis and morphogenesis. Development. 2011 Sep;138(18):3865-78
3*	J:157956 Gordon J, Patel SR, Mishina Y, Manley NR, Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis. Dev Biol. 2010 Mar 1;339(1):141-54
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:173854 Grevellec A, Graham A, Tucker AS, Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids. Dev Biol. 2011 May 15;353(2):194-205
3*	J:145693 Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER, Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev Biol. 2009 Mar 1;327(1):216-27
1	J:161634 Grigorieva IV, Mirczuk S, Gaynor KU, Nesbit MA, Grigorieva EF, Wei Q, Ali A, Fairclough RJ, Stacey JM, Stechman MJ, Mihai R, Kurek D, Fraser WD, Hough T, Condie BG, Manley N, Grosveld F, Thakker RV, Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest. 2010 Jun 1;120(6):2144-55
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:105259 Guris DL, Duester G, Papaioannou VE, Imamoto A, Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev Cell. 2006 Jan;10(1):81-92
1	J:279006 Hasten E, Morrow BE, Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome. PLoS Genet. 2019 Aug;15(8):e1008301
3	J:175891 Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K, Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells. Nat Neurosci. 2011 Aug;14(8):957-64
1	J:158677 Huh SH, Ornitz DM, Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development. 2010 Apr;137(7):1137-47
3	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
5	J:109989 Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y, Ikenaka K, The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes. Development. 2003 Dec;130(24):6027-35
5*	J:50339 Kim J, Jones BW, Zock C, Chen Z, Wang H, Goodman CS, Anderson DJ, Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12364-9
11*	J:167511 Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, Manley NR, Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genet. 2010;6(12):e1001251
4*	J:121311 Liu Z, Yu S, Manley NR, Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
1	J:320197 Magaletta ME, Lobo M, Kernfeld EM, Aliee H, Huey JD, Parsons TJ, Theis FJ, Maehr R, Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development. Nat Commun. 2022 Jan 24;13(1):457
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
5*	J:112870 Mager J, Schultz RM, Brunk BP, Bartolomei MS, Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. Mamm Genome. 2006 Sep;17(9):941-9
3*	J:95019 Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML, Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol. 2004 Dec 15;276(2):301-12
2*	J:104611 Moore-Scott BA, Manley NR, Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol. 2005 Feb 15;278(2):323-35
1	J:327225 Nagakubo D, Hirakawa M, Iwanami N, Boehm T, Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Sci Rep. 2022 Aug 8;12(1):13554
1	J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
1*	J:112219 Patel SR, Gordon J, Mahbub F, Blackburn CC, Manley NR, Bmp4 and Noggin expression during early thymus and parathyroid organogenesis. Gene Expr Patterns. 2006 Dec;6(8):794-9
1	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
2*	J:280399 Singh A, Mia MM, Cibi DM, Arya AK, Bhadada SK, Singh MK, Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice. J Biol Chem. 2019 May 24;294(21):8336-8347
2*	J:71183 Su D, Ellis S, Napier A, Lee K, Manley NR, Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis. Dev Biol. 2001 Aug 15;236(2):316-29
2*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
1	J:255792 Swann JB, Krauth B, Happe C, Boehm T, Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment. Sci Rep. 2017 Aug 17;7(1):8492
5*	J:136315 Takahashi K, Ishida M, Hirokawa K, Takahashi H, Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus. Dev Dyn. 2008 Jun;237(6):1699-708
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3*	J:180986 Wei Q, Condie BG, A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
3	J:79848 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44
1	J:273271 Yamada T, Tatsumi N, Anraku A, Suzuki H, Kamejima S, Uchiyama T, Ohkido I, Yokoo T, Okabe M, Gcm2 regulates the maintenance of parathyroid cells in adult mice. PLoS One. 2019;14(1):e0210662
1	J:95866 Zamisch M, Moore-Scott B, Su DM, Lucas PJ, Manley N, Richie ER, Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol. 2005 Jan 1;174(1):60-7
1	J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512