Gene Expression Literature Summary

• Symbol: Slc12a5
• Name: solute carrier family 12, member 5
• ID: MGI:1862037

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)	1	1		1	1	1		3	2	1	1	4	3			3	2	1	6		2	10
In situ RNA (section)					2		2		2		3		3		1			1	5			5
In situ RNA (whole mount)	1		1		1				1
Northern blot																			2
Western blot													1	1			4		5			6
RT-PCR							1								1	1	1	3	1	1		6
cDNA clones												1										1
RNase protection										1		1					1		1			2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Slc12a5  solute carrier family 12, member 5   (Synonyms: KCC2, mKIAA1176)
Results	Reference
3*	J:81579 Aguado F, Carmona MA, Pozas E, Aguilo A, Martinez-Guijarro FJ, Alcantara S, Borrell V, Yuste R, Ibanez CF, Soriano E, BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2. Development. 2003 Apr;130(7):1267-80
3	J:264778 Amadeo A, Coatti A, Aracri P, Ascagni M, Iannantuoni D, Modena D, Carraresi L, Brusco S, Meneghini S, Arcangeli A, Pasini ME, Becchetti A, Postnatal Changes in K(+)/Cl(-) Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy. Neuroscience. 2018 Aug 21;386:91-107
2*	J:174114 Batista-Brito R, Machold R, Klein C, Fishell G, Gene expression in cortical interneuron precursors is prescient of their mature function. Cereb Cortex. 2008 Oct;18(10):2306-17
1	J:86183 Boettger T, Rust MB, Maier H, Seidenbecher T, Schweizer M, Keating DJ, Faulhaber J, Ehmke H, Pfeffer C, Scheel O, Lemcke B, Horst J, Leuwer R, Pape HC, Volkl H, Hubner CA, Jentsch TJ, Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J. 2003 Oct 15;22(20):5422-34
2	J:260635 Bowerman M, Salsac C, Bernard V, Soulard C, Dionne A, Coque E, Benlefki S, Hince P, Dion PA, Butler-Browne G, Camu W, Bouchard JP, Delpire E, Rouleau GA, Raoul C, Scamps F, KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. Neurobiol Dis. 2017 Oct;106:35-48
1*	J:284004 Branchereau P, Martin E, Allain AE, Cazenave W, Supiot L, Hodeib F, Laupenie A, Dalvi U, Zhu H, Cattaert D, Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks. Elife. 2019 Dec 23;8:e51402
1*	J:147160 Chambers D, Wilson LJ, Alfonsi F, Hunter E, Saxena U, Blanc E, Lumsden A, Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6
1	J:221098 Chapuis C, Autran S, Fortin G, Simmers J, Thoby-Brisson M, Emergence of sigh rhythmogenesis in the embryonic mouse. J Physiol. 2014 May 15;592(Pt 10):2169-81
1	J:353356 da Cunha Menezes E, de Abreu FF, Davis JB, Maurer SV, Roshko VC, Richardson A, Dowell J, Cassella SN, Stevens HE, Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Dev Biol. 2024 Nov;515:112-120
1	J:196342 Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, Pachnis V, Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012 Nov 29;2(5):1351-62
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5	J:163030 Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E, Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010 Jun;31(12):2142-55
2*	J:94053 Hubner CA, Hentschke M, Jacobs S, Hermans-Borgmeyer I, Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development. Gene Expr Patterns. 2004 Dec;5(2):219-23
7*	J:69625 Hubner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ, Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition. Neuron. 2001 May;30(2):515-24
3	J:94810 Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa TO, Taketo MM, Fukuda A, Kawakami K, Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci. 2004 Nov 24;24(47):10693-701
1	J:292850 Imbriglio T, Verhaeghe R, Martinello K, Pascarelli MT, Chece G, Bucci D, Notartomaso S, Quattromani M, Mascio G, Scalabri F, Simeone A, Maccari S, Del Percio C, Wieloch T, Fucile S, Babiloni C, Battaglia G, Limatola C, Nicoletti F, Cannella M, Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors. FASEB J. 2019 Dec;33(12):14204-14220
1	J:258182 Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T, Oki Y, Fukuda A, A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence. Sci Adv. 2016 Aug;2(8):e1501723
2	J:180218 Khalilov I, Chazal G, Chudotvorova I, Pellegrino C, Corby S, Ferrand N, Gubkina O, Nardou R, Tyzio R, Yamamoto S, Jentsch TJ, Hubner CA, Gaiarsa JL, Ben-Ari Y, Medina I, Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Front Cell Neurosci. 2011;5:23
4	J:266531 Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C, Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior. Neurosci Res. 2018 Sep;134:39-48
7*	J:193557 Kosaka Y, Kin H, Tatetsu M, Uema I, Takayama C, Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord. Brain Res. 2012 Nov 27;1486:39-52
1	J:332233 Kurki SN, Uvarov P, Pospelov AS, Trontti K, Hubner AK, Srinivasan R, Watanabe M, Hovatta I, Hubner CA, Kaila K, Virtanen MA, Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development. Cereb Cortex. 2022 Dec 27;
2	J:308815 Larimore J, Zlatic SA, Arnold M, Singleton KS, Cross R, Rudolph H, Bruegge MV, Sweetman A, Garza C, Whisnant E, Faundez V, Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus. Front Genet. 2017;8:28
3*	J:282974 Lee M, Liu YC, Chen C, Lu CH, Lu ST, Huang TN, Hsu MT, Hsueh YP, Cheng PL, Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol. 2020 Feb 3;219(2)
1	J:301112 Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV, Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:98308 Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL, Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 2005 Apr 7;46(1):37-49
1*	J:193641 Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Banfi B, A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
2*	J:281311 Nakano Y, Wiechert S, Banfi B, Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8
1	J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
3*	J:332092 Rigkou A, Magyar A, Speer JM, Roussa E, TGF-beta2 Regulates Transcription of the K(+)/Cl(-) Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons. Cells. 2022 Nov 30;11(23)
1	J:156036 Schilling K, Oberdick J, The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Cerebellum. 2009 Dec;8(4):477-89
1*	J:288517 Spoljaric I, Spoljaric A, Mavrovic M, Seja P, Puskarjov M, Kaila K, KCC2-Mediated Cl(-) Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep. 2019 Jan 29;26(5):1073-1081.e3
13	J:87826 Stein V, Hermans-Borgmeyer I, Jentsch TJ, Hubner CA, Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J Comp Neurol. 2004 Jan 1;468(1):57-64
4	J:119945 Takayama C, Inoue Y, Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. Neurosci Res. 2007 Feb;57(2):322-5
2*	J:233793 Taylor-Burds C, Cheng P, Wray S, Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. PLoS One. 2015;10(6):e0131076
3	J:101079 Tornberg J, Voikar V, Savilahti H, Rauvala H, Airaksinen MS, Behavioural phenotypes of hypomorphic KCC2-deficient mice. Eur J Neurosci. 2005 Mar;21(5):1327-37
6*	J:126757 Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS, A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem. 2007 Oct 19;282(42):30570-6
3	J:149913 Uvarov P, Ludwig A, Markkanen M, Soni S, Hubner CA, Rivera C, Airaksinen MS, Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J Biol Chem. 2009 May 15;284(20):13696-704
2	J:102886 Uvarov P, Pruunsild P, Timmusk T, Airaksinen MS, Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene. J Neurochem. 2005 Nov;95(4):1144-55
1*	J:346887 Watanabe M, Sinha AS, Shinmyo Y, Fukuda A, Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation. Front Mol Neurosci. 2024;17:1373337
2	J:283808 Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT, Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Sci Signal. 2019 Oct 15;12(603)
3	J:122318 Wojcik SM, Katsurabayashi S, Guillemin I, Friauf E, Rosenmund C, Brose N, Rhee JS, A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron. 2006 May 18;50(4):575-87
4	J:350003 Zavalin K, Hassan A, Zhang Y, Khera Z, Lagrange AH, Region and layer-specific expression of GABA(A) receptor isoforms and KCC2 in developing cortex. Front Cell Neurosci. 2024;18:1390742