Gene Expression Literature Summary

• Symbol: Tbx21
• Name: T-box 21
• ID: MGI:1888984

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11	E11.5	E12	E13	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)						1	1		2		2	2		4			11
In situ RNA (section)			1			2		3	1	1		1		6		1	5
In situ RNA (whole mount)	1	1		1	1		1		2				1
In situ reporter (knock in)																	1
Western blot																	1
RT-PCR						1									1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tbx21  T-box 21   (Synonyms: T-bet, Tbet, Tblym, TBT1)
Results	Reference
1	J:244926 Amaniti EM, Kelman A, Mason JO, Theil T, Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract. PLoS One. 2015;10(10):e0141525
1	J:244587 Bastakis GG, Savvaki M, Stamatakis A, Vidaki M, Karagogeos D, Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells. Development. 2015 Dec 15;142(24):4318-28
1	J:171429 Besse L, Neti M, Anselme I, Gerhardt C, Ruther U, Laclef C, Schneider-Maunoury S, Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development. 2011 May;138(10):2079-88
1*	J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21
1	J:340527 Cai C, Luo Q, Jia L, Xia Y, Lan X, Wei X, Shi S, Liu Y, Wang Y, Xiong Z, Shi R, Huang C, Chen Z, TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb. Int J Mol Sci. 2023 Aug 30;24(17)
2	J:147117 Cheng TW, Gong Q, Secreted TARSH regulates olfactory mitral cell dendritic complexity. Eur J Neurosci. 2009 Mar;29(6):1083-95
1	J:266242 Desmaris E, Keruzore M, Saulnier A, Ratie L, Assimacopoulos S, De Clercq S, Nan X, Roychoudhury K, Qin S, Kricha S, Chevalier C, Lingner T, Henningfeld KA, Zarkower D, Mallamaci A, Theil T, Campbell K, Pieler T, Li M, Grove EA, Bellefroid EJ, DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121
3	J:174520 Enomoto T, Ohmoto M, Iwata T, Uno A, Saitou M, Yamaguchi T, Kominami R, Matsumoto I, Hirota J, Bcl11b/Ctip2 Controls the Differentiation of Vomeronasal Sensory Neurons in Mice. J Neurosci. 2011 Jul 13;31(28):10159-10173
3*	J:78160 Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A, Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mech Dev. 2002 Aug;116(1-2):157-60
1	J:226998 Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ, Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:107405 Hirata T, Nakazawa M, Yoshihara S, Miyachi H, Kitamura K, Yoshihara Y, Hibi M, Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development. 2006 Apr;133(8):1433-43
8	J:197480 Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S, Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci. 2013 Feb;16(2):157-65
1	J:121744 Inoue T, Ota M, Ogawa M, Mikoshiba K, Aruga J, Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J Neurosci. 2007 May 16;27(20):5461-73
1	J:207606 Kahoud RJ, Elsen GE, Hevner RF, Hodge RD, Conditional ablation of Tbr2 results in abnormal development of the olfactory bulbs and subventricular zone-rostral migratory stream. Dev Dyn. 2014 Mar;243(3):440-50
1*	J:248943 Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY, Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Jun 15;546(7658):421-425
1	J:251661 Li Z, Zhang T, Lin Z, Hou C, Zhang J, Men Y, Li H, Gao J, Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice. PLoS One. 2016;11(9):e0162126
4	J:185648 Mizuguchi R, Naritsuka H, Mori K, Yoshihara Y, Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. J Neurosci. 2012 Jun 27;32(26):8831-44
4	J:280405 Nguyen UP, Imamura F, Regional differences in mitral cell development in mouse olfactory bulb. J Comp Neurol. 2019 Oct 1;527(14):2233-2244
1	J:162564 Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M, Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13366-71
1	J:336383 Ruiz-Reig N, Andres B, Huilgol D, Grove EA, Tissir F, Tole S, Theil T, Herrera E, Fairen A, Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells. Cereb Cortex. 2017 May 1;27(5):2841-2856
1*	J:277331 Sah RK, Yang A, Bah FB, Adlat S, Bohio AA, Oo ZM, Wang C, Myint MZZ, Bahadar N, Zhang L, Feng X, Zheng Y, Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. PLoS One. 2019;14(7):e0213702
1	J:119799 Saha B, Hari P, Huilgol D, Tole S, Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract. J Neurosci. 2007 Feb 28;27(9):2290-7
1	J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:317903 Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R, Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb. J Anat. 2016 May;228(5):792-804
1	J:260656 Umemura M, Tsunematsu K, Shimizu YI, Nakano H, Takahashi S, Higashiura Y, Okabe M, Takahashi Y, Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron. Biosci Biotechnol Biochem. 2015;79(7):1082-9
2	J:107576 Waclaw RR, Allen ZJ 2nd, Bell SM, Erdelyi F, Szabo G, Potter SS, Campbell K, The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. 2006 Feb 16;49(4):503-16
1	J:116039 Walz A, Omura M, Mombaerts P, Development and topography of the lateral olfactory tract in the mouse: imaging by genetically encoded and injected fluorescent markers. J Neurobiol. 2006 Jul;66(8):835-46
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:96969 Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y, Arx homeobox gene is essential for development of mouse olfactory system. Development. 2005 Feb;132(4):751-62