Gene Expression Literature Summary

• Symbol: Pcdh15
• Name: protocadherin 15
• ID: MGI:1891428

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E18	E18.5	P
Immunohistochemistry (section)		1	1		1		1					1	2
In situ RNA (section)	1			1			1	1	1				2
Immunohistochemistry (whole mount)													2
Western blot						1				1			3
RT-PCR			1					1		1	1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pcdh15  protocadherin 15   (Synonyms: Gm9815, nmf19, roda, Ush1f)
Results	Reference
1*	J:244562 Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM, CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017 Jun 29;8(1):43
1	J:266273 Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK, FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8388-8393
1*	J:153683 Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D, Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17534-9
3*	J:151359 Lelli A, Asai Y, Forge A, Holt JR, Geleoc GS, Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. J Neurophysiol. 2009 Jun;101(6):2961-73
1	J:230827 Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C, Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016 Jan 18;212(2):231-44
6	J:244775 Libe-Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, Metin C, Michalski N, Petit C, Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774
2*	J:296648 Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA, Smith AD, McMahon AP, Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. J Am Soc Nephrol. 2018 Mar;29(3):806-824
3	J:348850 Mori D, Inami C, Ikeda R, Sawahata M, Urata S, Yamaguchi ST, Kobayashi Y, Fujita K, Arioka Y, Okumura H, Kushima I, Kodama A, Suzuki T, Hirao T, Yoshimi A, Sobue A, Ito T, Noda Y, Mizoguchi H, Nagai T, Kaibuchi K, Okabe S, Nishiguchi K, Kume K, Yamada K, Ozaki N, Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature. Transl Psychiatry. 2024 May 28;14(1):216
4*	J:70588 Murcia CL, Woychik RP, Expression of Pcdh15 in the inner ear, nervous system and various epithelia of the developing embryo. Mech Dev. 2001 Jul;105(1-2):163-6
1	J:230346 Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T, Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26
1	J:195357 Roeseler DA, Sachdev S, Buckley DM, Joshi T, Wu DK, Xu D, Hannink M, Waters ST, Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One. 2012;7(11):e47366
2*	J:221671 Scheffer DI, Shen J, Corey DP, Chen ZY, Gene Expression by Mouse Inner Ear Hair Cells during Development. J Neurosci. 2015 Apr 22;35(16):6366-80
2	J:325092 Zhen Y, Cullen CL, Ricci R, Summers BS, Rehman S, Ahmed ZM, Foster AY, Emery B, Gasperini R, Young KM, Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways. Commun Biol. 2022 May 30;5(1):511