Gene Expression Literature Summary

• Symbol: Psenen
• Name: presenilin enhancer gamma secretase subunit
• ID: MGI:1913590

9 matching records from 9 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E11.5	E13.5	E15	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)						1	1
In situ RNA (section)	1	1		1	1			1	1
In situ RNA (whole mount)				1
Northern blot									1
Western blot		1	1		1				5
RT-PCR		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Psenen  presenilin enhancer gamma secretase subunit   (Synonyms: 1700023M09Rik, Pen2)
Results	Reference
2	J:273599 Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Liang J, Stone Shi Y, Zheng Y, Lu J, Chen G, Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019 Mar 20;39(12):2195-2207
3	J:97674 Culvenor JG, Ilaya NT, Ryan MT, Canterford L, Hoke DE, Williamson NA, McLean CA, Masters CL, Evin G, Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations. Eur J Biochem. 2004 Jan;271(2):375-85
1	J:321806 Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM, JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. J Clin Invest. 2022 Mar 1;132(5):e142338
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:327484 Klein M, Kaleem A, Oetjen S, Wunkhaus D, Binkle L, Schilling S, Gjorgjieva M, Scholz R, Gruber-Schoffnegger D, Storch S, Kins S, Drewes G, Hoffmeister-Ullerich S, Kuhl D, Hermey G, Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system. Autophagy. 2022 Sep;18(9):2068-2085
1	J:236499 Liu L, Watanabe N, Akatsu H, Nishimura M, Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016 Aug 25;330:236-46
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:219929 Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd, Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron. 2015 Mar 4;85(5):967-81
3	J:325764 Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji MH, Chen G, Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus. Development. 2022 May 15;149(10):dev200272