Gene Expression Literature Summary

• Symbol: Nipbl
• Name: NIPBL cohesin loading factor
• ID: MGI:1913976

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10	E10.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E17.5	P
Immunohistochemistry (section)		1	1
In situ RNA (section)				1		1	1	2	2				1
RT-PCR	1	1	1	2						1	1	2
cDNA clones					1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nipbl  NIPBL cohesin loading factor   (Synonyms: 4921518A06Rik, 4933421G18Rik)
Results	Reference
1*	J:342613 Boulet F, Odelin G, Harrington A, Moore-Morris T, Nipbl Haploinsufficiency Leads to Delayed Outflow Tract Septation and Aortic Valve Thickening. Int J Mol Sci. 2023 Oct 25;24(21)
1*	J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167
2*	J:316587 Fazio G, Gaston-Massuet C, Bettini LR, Graziola F, Scagliotti V, Cereda A, Ferrari L, Mazzola M, Cazzaniga G, Giordano A, Cotelli F, Bellipanni G, Biondi A, Selicorni A, Pistocchi A, Massa V, CyclinD1 Down-Regulation and Increased Apoptosis Are Common Features of Cohesinopathies. J Cell Physiol. 2016 Mar;231(3):613-22
1	J:331699 Kean CM, Tracy CJ, Mitra A, Rahat B, Van Winkle MT, Gebert CM, Noeker JA, Calof AL, Lander AD, Kassis JA, Pfeifer K, Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl(+/-) embryos. Sci Adv. 2022 Dec 2;8(48):eadd4136
1	J:342642 Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R, BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 Oct;53(10):1480-1492
3*	J:93141 Mattar P, Britz O, Johannes C, Nieto M, Ma L, Rebeyka A, Klenin N, Polleux F, Guillemot F, Schuurmans C, A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol. 2004 Sep 15;273(2):373-89
1	J:228776 Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof AL, Lander AD, Schilling TF, Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 2014 Sep;10(9):e1004671
1*	J:204095 Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A, Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013 Dec;1832(12):2097-102
1	J:236978 Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL, Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
4	J:297065 Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S, IRX3/5 regulate mitotic chromatid segregation and limb bud shape. Development. 2020 Oct 5;147(19):dev180042
3	J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
1*	J:243510 van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urban N, Dekkers DH, Demmers JA, Guillemot F, Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron. 2017 Jan 18;93(2):348-361
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6