Gene Expression Literature Summary

• Symbol: P2ry12
• Name: purinergic receptor P2Y, G-protein coupled 12
• ID: MGI:1918089

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E18.5	E19	P
Immunohistochemistry (section)	1	4	1	1	3	2	3	1	2	1	2	1	8
In situ RNA (section)					1								3
In situ reporter (knock in)													1
Western blot								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

P2ry12  purinergic receptor P2Y, G-protein coupled 12   (Synonyms: 2900079B22Rik, 4921504D23Rik, P2Y12)
Results	Reference
1*	J:293626 Allon G, Mann I, Remez L, Sehn E, Rizel L, Nevet MJ, Perlman I, Wolfrum U, Ben-Yosef T, PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation. Hum Mol Genet. 2019 Dec 15;28(24):4078-4088
1	J:317789 Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, Chang EF, Li G, Grant GA, Hayden Gephart MG, Barres BA, New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
1	J:269384 Cheadle L, Tzeng CP, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, Chen C, Greenberg ME, Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Neuron. 2018 Aug 8;99(3):525-539.e10
1*	J:186298 Chen D, Wang W, Guo W, Yu Q, Burnstock G, He C, Xiang Z, Zheng H, Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair. J Anat. 2011 Jun;218(6):643-51
5	J:326255 Chen Y, Zhang H, Zhao Y, Zhang Y, Yin S, Hu Y, Ma G, Lu D, Sun J, Microglial integrin, chemokine receptors, and inflammatory response vary with development. Biochem Biophys Res Commun. 2022 Jul 30;615:94-101
2	J:329269 Cserep C, Schwarcz AD, Posfai B, Laszlo ZI, Kellermayer A, Kornyei Z, Kisfali M, Nyerges M, Lele Z, Katona I, Adam Denes, Microglial control of neuronal development via somatic purinergic junctions. Cell Rep. 2022 Sep 20;40(12):111369
5*	J:333946 Hattori Y, Kato D, Murayama F, Koike S, Asai H, Yamasaki A, Naito Y, Kawaguchi A, Konishi H, Prinz M, Masuda T, Wake H, Miyata T, CD206(+) macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia. Cell Rep. 2023 Feb 7;42(2):112092
2	J:287499 Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A, Miyata T, Transient microglial absence assists postmigratory cortical neurons in proper differentiation. Nat Commun. 2020 Apr 2;11(1):1631
1	J:314108 Jecrois ES, Zheng W, Bornhorst M, Li Y, Treisman DM, Muguyo D, Huynh S, Andrew SF, Wang Y, Jiang J, Pierce BR, Mao H, Krause MK, Friend A, Nadal-Nicolas F, Stasheff SF, Li W, Zong H, Packer RJ, Zhu Y, Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Dev Cell. 2021 Oct 25;56(20):2871-2885.e6
1	J:310641 Li C, Konishi H, Nishiwaki K, Sato K, Miyata T, Kiyama H, A mouse model of microglia-specific ablation in the embryonic central nervous system. Neurosci Res. 2021 Jun 23;
1*	J:299738 Liu Y, Yang M, Deng Y, Su G, Enninful A, Guo CC, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R, High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. Cell. 2020 Dec 10;183(6):1665-1681.e18
1*	J:270210 Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ, Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134
2	J:330324 Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernandez-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lammermann T, Priller J, Kierdorf K, Prinz M, Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748
1	J:354190 Morimoto K, Takahashi R, Takahashi G, Miyajima M, Nakajima K, Maternal immunoglobulins are distributed in the offspring's brain to support the maintenance of cortical interneurons in the postnatal period. Inflamm Regen. 2024 May 15;44(1):24
1	J:305421 Rosin JM, Sinha S, Biernaskie J, Kurrasch DM, A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Dev Cell. 2021 May 3;56(9):1326-1345.e6
2	J:326459 Scott EP, Breyak E, Nishinakamura R, Nakagawa Y, The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos. Glia. 2022 Sep;70(9):1720-1733
1	J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
3	J:292317 Utz SG, See P, Mildenberger W, Thion MS, Silvin A, Lutz M, Ingelfinger F, Rayan NA, Lelios I, Buttgereit A, Asano K, Prabhakar S, Garel S, Becher B, Ginhoux F, Greter M, Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development. Cell. 2020 Apr 30;181(3):557-573.e18
3	J:344239 Wang Y, Wang W, Su L, Ji F, Zhang M, Xie Y, Zhang T, Jiao J, BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. Dev Cell. 2024 Jan 8;59(1):108-124.e7
1*	J:330602 Zhou T, Li Y, Li X, Zeng F, Rao Y, He Y, Wang Y, Liu M, Li D, Xu Z, Zhou X, Du S, Niu F, Peng J, Mei X, Ji SJ, Shu Y, Lu W, Guo F, Wu T, Yuan TF, Mao Y, Peng B, Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022 Oct 24;13(1):6233