Gene Expression Literature Summary

• Symbol: Setd2
• Name: SET domain containing 2
• ID: MGI:1918177

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E18	E18.5	P
Immunohistochemistry (section)						1		1		1	1	1		1	1			1	1
In situ RNA (section)											1		2	1
Immunohistochemistry (whole mount)	1	1	1	1	1
Western blot							1									1
RT-PCR	1					1	1		1	1	1	1	1	1	1		1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Setd2  SET domain containing 2   (Synonyms: 4921524K10Rik, KMT3A)
Results	Reference
1	J:346179 Abe S, Nagatomo H, Sasaki H, Ishiuchi T, A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation. Epigenetics. 2021 Oct;16(10):1123-1134
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
6	J:306392 Chen F, Chen J, Wang H, Tang H, Huang L, Wang S, Wang X, Fang X, Liu J, Li L, Ouyang K, Han Z, Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts. Front Cell Dev Biol. 2021;9:651655
1	J:355653 Chen S, Liu D, Chen B, Li Z, Chang B, Xu C, Li N, Feng C, Hu X, Wang W, Zhang Y, Xie Y, Huang Q, Wang Y, Nimer SD, Chen S, Chen Z, Wang L, Sun X, Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation. Front Med. 2024 Aug 8;
1	J:305283 Li Y, Tang H, Chen F, Chen J, Wang H, Chen Z, Duan Y, Wang X, Li L, Ouyang K, SETD2 is essential for terminal differentiation of erythroblasts during fetal erythropoiesis. Biochem Biophys Res Commun. 2021 May 7;552:98-105
7	J:346058 Lu P, Xu J, Shen X, Sun J, Liu M, Niu N, Wang Q, Xue J, Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis. Cell Rep. 2024 Feb 27;43(2):113703
5*	J:276643 Oqani RK, Lin T, Lee JE, Kang JW, Shin HY, Il Jin D, Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Sci Rep. 2019 Mar 7;9(1):3831
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
7*	J:307957 Xie X, Wang S, Li M, Diao L, Pan X, Chen J, Zou W, Zhang X, Feng W, Bao L, alpha-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. Nat Commun. 2021 Jul 5;12(1):4113
3	J:313451 Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu F, Wu X, Wu M, Zhou Y, Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv. 2021 Jan;7(1)
1	J:203796 Zhang K, Haversat JM, Mager J, CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol. 2013 Nov 1;383(1):15-27