Gene Expression Literature Summary

• Symbol: Flrt3
• Name: fibronectin leucine rich transmembrane protein 3
• ID: MGI:1918686

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6	E6.5	E7	E7.5	E8	E8.5	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)		1	1			2	2	1	2					1	3		2	2		1			1
In situ RNA (section)						2			3	1	1	1		3	6		3	1			1	1	4
In situ RNA (whole mount)	1	1			2	3	3		4	1												1
In situ reporter (knock in)	1	1	2	2	1	2	1		1					2	1		2			1		1	1
Northern blot																1							2
Western blot						1	2						1		1	1			1				2
RT-PCR		1																					1
cDNA clones									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Flrt3  fibronectin leucine rich transmembrane protein 3   (Synonyms: 5530600M07Rik, C430047I10Rik, mKIAA1469)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5	J:241499 Del Toro D, Ruff T, Cederfjall E, Villalba A, Seyit-Bremer G, Borrell V, Klein R, Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Cell. 2017 May 04;169(4):621-635.e16
1	J:353553 Despin-Guitard E, Rosa VS, Plunder S, Mathiah N, Van Schoor K, Nehme E, Merino-Aceituno S, Egea J, Shahbazi MN, Theveneau E, Migeotte I, Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
14	J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
4	J:309391 Fleitas C, Marfull-Oromi P, Chauhan D, Del Toro D, Peguera B, Zammou B, Rocandio D, Klein R, Espinet C, Egea J, FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development. J Neurosci. 2021 Sep 1;41(35):7350-7362
10*	J:152487 Gong SG, Mai S, Chung K, Wei K, Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development. Gene Expr Patterns. 2009 Oct;9(7):497-502
8*	J:112631 Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW, Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
2	J:303701 He L, Jones J, He W, Bjork BC, Wen J, Dai Q, PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors. Development. 2021 Mar 17;148(6):dev194670
2	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
2*	J:224719 Leyva-Diaz E, del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, Klein R, Egea J, Lopez-Bendito G, FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014 Mar 3;24(5):494-508
1	J:348278 Liakath-Ali K, Refaee R, Sudhof TC, Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development. PLoS Biol. 2024 May;22(5):e3002599
14*	J:136719 Maretto S, Muller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ, Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 2008 Jun 1;318(1):184-93
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2*	J:203635 Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N, Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 2;92(5):725-43
2	J:125931 Muhlfriedel S, Kirsch F, Gruss P, Chowdhury K, Stoykova A, Novel genes differentially expressed in cortical regions during late neurogenesis. Eur J Neurosci. 2007 Jul;26(1):33-50
8	J:171515 Muller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E, The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
1	J:218226 Seiradake E, del Toro D, Nagel D, Cop F, Hartl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R, FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron. 2014 Oct 22;84(2):370-85
2*	J:86309 Tanabe K, Bonilla I, Winkles JA, Strittmatter SM, Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J Neurosci. 2003 Oct 22;23(29):9675-86
1	J:197638 van den Berghe V, Stappers E, Vandesande B, Dimidschstein J, Kroes R, Francis A, Conidi A, Lesage F, Dries R, Cazzola S, Berx G, Kessaris N, Vanderhaeghen P, van Ijcken W, Grosveld FG, Goossens S, Haigh JJ, Fishell G, Goffinet A, Aerts S, Huylebroeck D, Seuntjens E, Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron. 2013 Jan 9;77(1):70-82
3	J:325905 Willnow D, Benary U, Margineanu A, Vignola ML, Konrath F, Pongrac IM, Karimaddini Z, Vigilante A, Wolf J, Spagnoli FM, Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche. Nature. 2021 Sep;597(7874):87-91
5	J:196042 Yamagishi S, Hampel F, Hata K, Del Toro D, Schwark M, Kvachnina E, Bastmeyer M, Yamashita T, Tarabykin V, Klein R, Egea J, FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 2011 Jul 20;30(14):2920-33
5	J:343098 Zhou Z, Pan Y, Zhou S, Wang S, Zhang D, Cao Y, Jiang X, Li J, Zhu L, Zhao L, Gu S, Lin G, Dong Z, Sun HX, Single-cell analysis reveals specific neuronal transition during mouse corticogenesis. Front Cell Dev Biol. 2023;11:1209320