Gene Expression Literature Summary

• Symbol: Cul4b
• Name: cullin 4B
• ID: MGI:1919834

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E3	E3.5	E4	E4.5	E5	E6.5	E7.5	E9.5	E10.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	P
Immunohistochemistry (section)								1	1	4			1		1	1		1	4
Immunohistochemistry (whole mount)		1			1	1	1												1
Western blot											1		1	1	1		1	1	5
RT-PCR	1	1	1	1	1						1	1							3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cul4b  cullin 4B   (Synonyms: 2700050M05Rik)
Results	Reference
3	J:277240 Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW, Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221
1	J:204566 Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N, Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
4	J:199139 Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C, Gong Y, Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 2012;7(5):e37070
2*	J:254519 Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, Zhang T, Song T, Zhao J, Endo Y, Lin H, Cai X, Cang Y, CRL4(DCAF8) Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017 Feb 7;18(6):1499-1511
2*	J:291732 Lin Y, Yu J, Wu J, Wang S, Zhang T, Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression. Epigenetics Chromatin. 2019 Apr 16;12(1):22
6	J:199210 Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P, Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res. 2012 Aug;22(8):1258-69
1*	J:314180 Matsuki T, Iio A, Ueda M, Tsuneura Y, Howell BW, Nakayama A, STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development. J Neurosci. 2021 Oct 27;41(43):8887-8903
1	J:116773 Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev. 2006 Dec 15;20(24):3382-94
1	J:331366 Song Y, Chen M, Zhang Y, Li J, Liu B, Li N, Chen M, Qiao M, Wang N, Cao Y, Lu S, Chen J, Sun W, Gao F, Wang H, Loss of circSRY reduces gammaH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance. 2023 Feb;6(2)
1	J:226978 Tateossian H, Morse S, Simon MM, Dean CH, Brown SD, Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42
2	J:312461 Yin Y, Zhu L, Li Q, Zhou P, Ma L, Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis. Cells. 2021 Oct 13;10(10)
9	J:205485 Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
5	J:223924 Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C, Gong Y, Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 2015 Aug 15;24(16):4686-97
2	J:196602 Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X, Jiang B, Shao C, Gong Y, CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 2013 Mar 18;200(6):743-56