Gene Expression Literature Summary

• Symbol: Rspo3
• Name: R-spondin 3
• ID: MGI:1920030

64 matching records from 64 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
In situ RNA (section)					1	3	8		4	11	13	12	1	6	4	1	5	7	1	12
In situ RNA (whole mount)		2	3	5	1	7	7		5	6	2	2						1	1
In situ reporter (knock in)			1	1		1	1		1	1
RT-PCR	1					2	5	1	2	4	5	5	1	3	1	1	2	1	1	8
cDNA clones										1									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Rspo3  R-spondin 3   (Synonyms: 2810459H04Rik, Cristin1, Thsd2)
Results	Reference
2	J:304831 Alhazmi N, Carroll SH, Kawasaki K, Woronowicz KC, Hallett SA, Macias Trevino C, Li EB, Baron R, Gori F, Yelick PC, Harris MP, Liao EC, Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Sci Rep. 2021 Mar 12;11(1):5871
15*	J:116978 Aoki M, Mieda M, Ikeda T, Hamada Y, Nakamura H, Okamoto H, R-spondin3 is required for mouse placental development. Dev Biol. 2007 Jan 1;301(1):218-26
1	J:310136 Armfield BA, Cohn MJ, Single cell transcriptomic analysis of external genitalia reveals complex and sexually dimorphic cell populations in the early genital tubercle. Dev Biol. 2021 Sep;477:145-154
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7	J:214093 Cambier L, Plate M, Sucov HM, Pashmforoush M, Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
1*	J:316185 Cesario J, Ha S, Kim J, Kataria N, Jeong J, Candidate positive targets of LHX6 and LHX8 transcription factors in the developing upper jaw. Gene Expr Patterns. 2021 Nov 30;43:119227
1*	J:223069 Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquie O, Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Sep;33(9):962-9
1	J:306392 Chen F, Chen J, Wang H, Tang H, Huang L, Wang S, Wang X, Fang X, Liu J, Li L, Ouyang K, Han Z, Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts. Front Cell Dev Biol. 2021;9:651655
1	J:153556 Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, Broccoli V, Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity. Dev Biol. 2009 Oct 1;334(1):59-71
3*	J:264603 Da Silva F, Massa F, Motamedi FJ, Vidal V, Rocha AS, Gregoire EP, Cai CL, Wagner KD, Schedl A, Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4. Dev Biol. 2018 Sep 1;441(1):42-51
6	J:254209 Da Silva F, Rocha AS, Motamedi FJ, Massa F, Basboga C, Morrison H, Wagner KD, Schedl A, Coronary Artery Formation Is Driven by Localized Expression of R-spondin3. Cell Rep. 2017 Aug 22;20(8):1745-1754
3	J:306023 Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK, A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 May 27;184(11):3056-3074.e21
4	J:309519 Dasgupta K, Cesario JM, Ha S, Asam K, Deacon LJ, Song AH, Kim J, Cobb J, Yoon JK, Jeong J, R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development. J Dev Biol. 2021 Aug 12;9(3)
2*	J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:312814 Fernandez Vallone V, Leprovots M, Ribatallada-Soriano D, Gerbier R, Lefort A, Libert F, Vassart G, Garcia MI, LGR5 controls extracellular matrix production by stem cells in the developing intestine. EMBO Rep. 2020 Jul 3;21(7):e49224
1	J:357477 Ferrena A, Zhang X, Shrestha R, Zheng D, Liu W, Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells. PLoS One. 2024;19(10):e0308839
1	J:320618 Fleck JS, Sanchis-Calleja F, He Z, Santel M, Boyle MJ, Camp JG, Treutlein B, Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases. Cell Stem Cell. 2021 Jun 3;28(6):1148-1159.e8
1	J:331853 Gao R, Liang X, Cheedipudi S, Cordero J, Jisng X, Zhang Q, Caputo L, Gunther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G, Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019 Jun;29(6):486-501
2	J:332216 Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo MV, Epstein DJ, Camara PG, Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation. Cell Rep. 2022 Dec 6;41(10):111768
2	J:202907 Grigoryan T, Stein S, Qi J, Wende H, Garratt AN, Nave KA, Birchmeier C, Birchmeier W, Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:278245 Guo Q, Li JYH, Defining developmental diversification of diencephalon neurons through single cell gene expression profiling. Development. 2019 Apr 1;146(12):dev174284
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
5*	J:308689 Gyllborg D, Ahmed M, Toledo EM, Theofilopoulos S, Yang S, Ffrench-Constant C, Arenas E, The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation. Stem Cell Reports. 2018 Sep 11;11(3):651-664
1	J:326662 Hamed AA, Kunz DJ, El-Hamamy I, Trinh QM, Subedar OD, Richards LM, Foltz W, Bullivant G, Ware M, Vladoiu MC, Zhang J, Raj AM, Pugh TJ, Taylor MD, Teichmann SA, Stein LD, Simons BD, Dirks PB, A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nat Commun. 2022 Jul 19;13(1):4178
1	J:203028 Hasenpusch-Theil K, Magnani D, Amaniti EM, Han L, Armstrong D, Theil T, Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex. 2012 Dec;22(12):2878-93
1	J:135511 Ishii Y, Wajid M, Bazzi H, Fantauzzo KA, Barber AG, Blaydon DC, Nam JS, Yoon JK, Kelsell DP, Christiano AM, Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. J Invest Dermatol. 2008 Apr;128(4):867-70
5*	J:210988 Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A, R-spondins/Lgrs expression in tooth development. Dev Dyn. 2014 Jun;243(6):844-51
7	J:215739 Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C, The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64
1	J:284576 Kim JE, Fei L, Yin WC, Coquenlorge S, Rao-Bhatia A, Zhang X, Shi SSW, Lee JH, Hahn NA, Rizvi W, Kim KH, Sung HK, Hui CC, Guo G, Kim TH, Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun. 2020 Jan 17;11(1):334
1	J:347128 Kumar N, Prakash PG, Wentland C, Kurian SM, Jethva G, Brinkmann V, Mollenkopf HJ, Krammer T, Toussaint C, Saliba AE, Biebl M, Jurgensen C, Wiedenmann B, Meyer TF, Gurumurthy RK, Chumduri C, Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis. Nat Commun. 2024 Apr 9;15(1):3064
3*	J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
2	J:306027 Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Matlik K, Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S, Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021 May 15;148(10):dev197475
1	J:337772 Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K, Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment. J Am Soc Nephrol. 2023 Apr 1;34(4):572-589
1	J:321068 Maimets M, Pedersen MT, Guiu J, Dreier J, Thodberg M, Antoku Y, Schweiger PJ, Rib L, Bressan RB, Miao Y, Garcia KC, Sandelin A, Serup P, Jensen KB, Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling. Nat Commun. 2022 Feb 7;13(1):715
7*	J:343094 Makela OJM, Mikkola ML, Mesenchyme governs hair follicle induction. Development. 2023 Nov 15;150(22):dev202140
1	J:349775 Matern MS, Durruthy-Durruthy R, Birol O, Darmanis S, Scheibinger M, Groves AK, Heller S, Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Rep. 2023 Jun 27;42(6):112545
2*	J:177133 Mehta V, Abler LL, Keil KP, Schmitz CT, Joshi PS, Vezina CM, Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. Dev Dyn. 2011 Nov;240(11):2548-60
1	J:148515 Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama KI, Kato S, Yamada G, Genetic interactions of the Androgen and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol. 2009 June;23(6):871-880
2	J:187747 Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS, Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
5*	J:191199 Mulvaney JF, Yatteau A, Sun WW, Jacques B, Takubo K, Suda T, Yamada W, Dabdoub A, Secreted Factor R-Spondin 2 is Involved in Refinement of Patterning of the Mammalian Cochlea. Dev Dyn. 2013 Feb;242(2):179-88
2*	J:113117 Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK, Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006 May 12;281(19):13247-57
16*	J:116140 Nam JS, Turcotte TJ, Yoon JK, Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns. 2007 Jan;7(3):306-12
3	J:188812 Neufeld S, Rosin JM, Ambasta A, Hui K, Shaneman V, Crowder R, Vickerman L, Cobb J, A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development. Genesis. 2012 Oct;50(10):741-9
1	J:240625 Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S, Soshnikova N, Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J. 2017 Apr 03;36(7):869-885
1	J:354194 Oikonomakos I, Tedesco M, Motamedi FJ, Peitzsch M, Nef S, Bornstein SR, Schedl A, Steenblock C, Neirijnck Y, In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
1	J:328944 Olbertova K, Hrckulak D, Kriz V, Jesionek W, Kubovciak J, Esner M, Korinek V, Buchtova M, Role of LGR5-positive mesenchymal cells in craniofacial development. Front Cell Dev Biol. 2022;10:810527
1	J:293401 Phua YL, Chen KH, Hemker SL, Marrone AK, Bodnar AJ, Liu X, Clugston A, Kostka D, Butterworth MB, Ho J, Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors. Am J Physiol Renal Physiol. 2019 May 1;316(5):F993-F1005
6	J:259735 Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A, The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. Cell Rep. 2015 Dec 1;13(9):1757-64
1	J:270627 Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P, Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet Muscle. 2016;6(1):30
1*	J:215514 Saulnier A, Keruzore M, De Clercq S, Bar I, Moers V, Magnani D, Walcher T, Filippis C, Kricha S, Parlier D, Viviani L, Matson CK, Nakagawa Y, Theil T, Gotz M, Mallamaci A, Marine JC, Zarkower D, Bellefroid EJ, The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals. Cereb Cortex. 2013 Nov;23(11):2552-67
1*	J:297081 Sayols S, Klassek J, Werner C, Mockel S, Ritz S, Mendez-Lago M, Soshnikova N, Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Development. 2020 Sep 15;147(18):dev188839
1	J:283792 Seishima R, Leung C, Yada S, Murad KBA, Tan LT, Hajamohideen A, Tan SH, Itoh H, Murakami K, Ishida Y, Nakamizo S, Yoshikawa Y, Wong E, Barker N, Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019 Nov 26;10(1):5378
2	J:253067 Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF, Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455
3*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1	J:171050 Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH, Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3	J:170400 Vickerman L, Neufeld S, Cobb J, Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Dev Biol. 2011 Feb 15;350(2):323-36
6	J:233303 Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A, The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes Dev. 2016 Jun 15;30(12):1389-94
5	J:290543 Vidal VP, Jian-Motamedi F, Rekima S, Gregoire EP, Szenker-Ravi E, Leushacke M, Reversade B, Chaboissier MC, Schedl A, R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. Elife. 2020 May 1;9:e53895
5*	J:341172 Watanabe K, Horie M, Hayatsu M, Mikami Y, Sato N, Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon. Gene Expr Patterns. 2023 Sep;49:119333
1*	J:307862 Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O, Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. Elife. 2021 May 18;10:e60108
5	J:272581 Wymeersch FJ, Skylaki S, Huang Y, Watson JA, Economou C, Marek-Johnston C, Tomlinson SR, Wilson V, Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning. Development. 2019 Jan 2;146(1):dev168161