Gene Expression Literature Summary

• Symbol: Sost
• Name: sclerostin
• ID: MGI:1921749

41 matching records from 41 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)						1	1	1	1	2		1	1	2	1			9
In situ RNA (section)	1		1	1	1		2		6		5	3	2		1			5
In situ RNA (whole mount)		1	1			1						1			1		1
In situ reporter (knock in)	2		2	2	2		2		2		2	1	1		2			2
Western blot																		2
RT-PCR			1	1	1				1	1	2	1	4	2	2	1		10
cDNA clones																		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sost  sclerostin   (Synonyms: 5430411E23Rik)
Results	Reference
1	J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72
1	J:261043 Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U, Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242
6	J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
8*	J:203431 Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG, Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
1	J:225092 Duverger O, Isaac J, Zah A, Hwang J, Berdal A, Lian JB, Morasso MI, In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol. 2013 Mar;228(3):654-64
1	J:216098 Ellies DL, Economou A, Viviano B, Rey JP, Paine-Saunders S, Krumlauf R, Saunders S, Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257
5	J:128100 Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R, Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res. 2006 Nov;21(11):1738-49
1	J:308983 Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF, The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 Aug 10;12(1):4797
1*	J:328711 Fernandez-Guerrero M, Zdral S, Castilla-Ibeas A, Lopez-Delisle L, Duboule D, Ros MA, Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2022 Sep;251(9):1550-1575
2	J:176483 Holmes G, Bromage TG, Basilico C, The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice. Bone. 2011 Oct;49(4):653-61
2	J:149465 Holmes G, Rothschild G, Roy UB, Deng CX, Mansukhani A, Basilico C, Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol. 2009 Apr 15;328(2):273-84
1*	J:235526 Jauregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T, Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone. 2016 Aug;89:7-15
1	J:182873 Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD, PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1;124(Pt 5):745-54
4	J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
5	J:294900 Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y, Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020 Aug 13;10(1):13751
2	J:316483 Leek CC, Soulas JM, Bhattacharya I, Ganji E, Locke RC, Smith MC, Bhavsar JD, Polson SW, Ornitz DM, Killian ML, Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn. 2021 Dec;250(12):1778-1795
1	J:314657 Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ, Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-43
2	J:320375 Mirigian LS, Makareeva E, Mertz EL, Omari S, Roberts-Pilgrim AM, Oestreich AK, Phillips CL, Leikin S, Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in alpha2(I)-G610C Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2016 Aug;31(8):1608-1616
5*	J:170473 Naka T, Yokose S, Spatiotemporal expression of sclerostin in odontoblasts during embryonic mouse tooth morphogenesis. J Endod. 2011 Mar;37(3):340-5
4	J:92630 Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M, Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct;145(10):4685-92
7	J:264160 Patoine A, Husseini A, Kasaai B, Gaumond MH, Moffatt P, The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice. PLoS One. 2017;12(9):e0184568
2*	J:340391 Pina JO, Raju R, Roth DM, Winchester EW, Chattaraj P, Kidwai F, Faucz FR, Iben J, Mitra A, Campbell K, Fridell G, Esnault C, Cotney JL, Dale RK, D'Souza RN, Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis. Nat Commun. 2023 Sep 14;14(1):5687
1	J:352719 Pina JO, Raju R, Roth DM, Winchester EW, Padilla C, Iben J, Faucz FR, Cotney JL, D'Souza RN, Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'. J Dent Res. 2024 Jun 23;:220345241256600
3*	J:132979 Potok MA, Cha KB, Hunt A, Brinkmeier ML, Leitges M, Kispert A, Camper SA, WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn. 2008 Apr;237(4):1006-20
7*	J:344641 Raju R, Pina JO, Roth DM, Chattaraj P, Kidwai FK, Faucz FR, Iben J, Fridell G, Dale RK, D'Souza RN, Profiles of Wnt pathway gene expression during tooth morphogenesis. Front Physiol. 2023;14:1316635
2*	J:255349 Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P, Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142
1*	J:306391 Roth DM, Baddam P, Lin H, Vidal-Garcia M, Aponte JD, De Souza ST, Godziuk D, Watson AES, Footz T, Schachter NF, Egan SE, Hallgrimsson B, Graf D, Voronova A, The Chromatin Regulator Ankrd11 Controls Palate and Cranial Bone Development. Front Cell Dev Biol. 2021;9:645386
1	J:263575 Ruiz P, Martin-Millan M, Gonzalez-Martin MC, Almeida M, Gonzalez-Macias J, Ros MA, CathepsinKCre mediated deletion of betacatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells. Sci Rep. 2016 Nov 2;6:36201
2*	J:309449 Sakurai A, Hasegawa T, Kudo A, Shen Z, Nagai T, Abe M, Yoshida T, Hongo H, Yamamoto T, Yamamoto T, Oda K, Freitas PHL, Li M, Sano H, Amizuka N, Chronological immunolocalization of sclerostin and FGF23 in the mouse metaphyseal trabecular and cortical bone. Biomed Res. 2017;38(4):257-267
2	J:314318 Svandova E, Vesela B, Lesot H, Sadoine J, Poliard A, Matalova E, FasL Modulates Expression of Mmp2 in Osteoblasts. Front Physiol. 2018;9:1314
7*	J:117264 van Bezooijen RL, Deruiter MC, Vilain N, Monteiro RM, Visser A, van der Wee-Pals L, van Munsteren CJ, Hogendoorn PC, Aguet M, Mummery CL, Papapoulos SE, Ten Dijke P, Lowik CW, SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development. Dev Dyn. 2007 Feb;236(2):606-12
3*	J:310061 Vesela B, Svandova E, Bobek J, Lesot H, Matalova E, Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells. Front Physiol. 2019;10:124
2*	J:320741 Vesela B, Svandova E, Hovorakova M, Peterkova R, Kratochvilova A, Pasovska M, Ramesova A, Lesot H, Matalova E, Specification of Sprouty2 functions in osteogenesis in in vivo context. Organogenesis. 2019;15(4):111-119
1	J:324690 Wang H, Zheng C, Lu W, He T, Fan J, Wang C, Jie Q, Chan D, Cheah KSE, Yang L, Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened. Matrix Biol. 2022 Apr 23;
1	J:320628 Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N, Mechanical load regulates bone growth via periosteal Osteocrin. Cell Rep. 2021 Jul 13;36(2):109380
1*	J:86838 Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR, Staehling-Hampton K, Appleby M, Brunkow ME, Latham JA, Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 2003 Dec 1;22(23):6267-76
3*	J:307192 Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y, Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118
1*	J:165583 Yang F, Tang W, So S, de Crombrugghe B, Zhang C, Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun. 2010 Oct 1;400(4):684-8
1	J:308926 Yang J, Kitami M, Pan H, Nakamura MT, Zhang H, Liu F, Zhu L, Komatsu Y, Mishina Y, Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic beta-catenin degradation. Sci Signal. 2021 Jan 12;14(665)
1*	J:281175 Yorgan TA, Peters S, Amling M, Schinke T, Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163
1	J:274387 Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C, Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep. 2017 Mar 22;7:45010