Gene Expression Literature Summary

• Symbol: Gpsm2
• Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
• ID: MGI:1923373

33 matching records from 33 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E7	E11	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)					2		1	4		4		6		4	2		8
In situ RNA (section)				1	2	1		3		2		2		1	1		3
Immunohistochemistry (whole mount)	1									1	1	4			4		9
In situ reporter (knock in)								1									1
Northern blot		1	1						1				1				1
Western blot						1	1									1	3
RT-PCR												1					3
cDNA clones			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gpsm2  G-protein signalling modulator 2 (AGS3-like, C. elegans)   (Synonyms: 6230410J09Rik, LGN, Pins)
Results	Reference
1	J:330604 Akturk A, Day M, Tarchini B, RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells. Sci Adv. 2022 Oct 21;8(42):eabq2826
6	J:235730 Byrd KM, Lough KJ, Patel JH, Descovich CP, Curtis TA, Williams SE, LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development. Development. 2016 Aug 1;143(15):2803-17
1	J:337788 Descovich CP, Lough KJ, Jena A, Wu JJ, Yom J, Spitzer DC, Uppalapati M, Kedziora KM, Williams SE, AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. Elife. 2023 Apr 5;12
1	J:242729 Ding X, Bloch W, Iden S, Ruegg MA, Hall MN, Leptin M, Partridge L, Eming SA, mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226
1	J:260456 Duteil D, Tourrette Y, Eberlin A, Willmann D, Patel D, Friedrichs N, Muller JM, Schule R, The histone acetyltransferase inhibitor Nir regulates epidermis development. Development. 2018 Mar 21;145(6):dev158543
2*	J:167828 El-Hashash AH, Warburton D, Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011 Feb;240(2):441-5
1	J:309675 Elias S, Thion MS, Yu H, Sousa CM, Lasgi C, Morin X, Humbert S, Huntingtin regulates mammary stem cell division and differentiation. Stem Cell Reports. 2014 Apr 8;2(4):491-506
2	J:201606 Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP, Le Bivic A, Nurnberg B, Sans N, Montcouquiol M, Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol. 2013 Sep;15(9):1107-15
1*	J:242313 Forge A, Taylor RR, Dawson SJ, Lovett M, Jagger DJ, Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
1	J:280869 Freeman S, Mateo Sanchez S, Pouyo R, Van Lerberghe PB, Hanon K, Thelen N, Thiry M, Morelli G, Van Hees L, Laguesse S, Chariot A, Nguyen L, Delacroix L, Malgrange B, Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Rep. 2019 Sep;20(9):e47097
2	J:310903 Gresakova V, Novosadova V, Prochazkova M, Prochazka J, Sedlacek R, Dual role of Fam208a during zygotic cleavage and early embryonic development. Exp Cell Res. 2021 Sep 15;406(2):112723
1	J:338698 Jarysta A, Tadenev ALD, Day M, Krawchuk B, Low BE, Wiles MV, Tarchini B, Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis. Elife. 2024 Apr 23;12
1	J:216288 Jones C, Qian D, Kim SM, Li S, Ren D, Knapp L, Sprinzak D, Avraham KB, Matsuzaki F, Chi F, Chen P, Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. Dev Biol. 2014 Nov 1;395(1):62-72
1	J:306060 Kindt KS, Akturk A, Jarysta A, Day M, Beirl A, Flonard M, Tarchini B, EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia. Nat Commun. 2021 May 17;12(1):2861
1	J:336512 Knapp L, Sun H, Wang YM, Chen BJ, Lin X, Gao N, Chen P, Ren D, Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti. eNeuro. 2023 Jun;10(6):ENEURO.0420-22.2023
3	J:132370 Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F, Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol. 2008 Jan;10(1):93-101
4	J:239974 Lacomme M, Tarchini B, Boudreau-Pinsonneault C, Monat C, Cayouette M, The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina. Development. 2016 Feb 15;143(4):575-81
1	J:147346 Lake BB, Sokol SY, Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol. 2009 Apr 6;185(1):59-66
2	J:273200 Landin Malt A, Dailey Z, Holbrook-Rasmussen J, Zheng Y, Hogan A, Du Q, Lu X, Par3 is essential for the establishment of planar cell polarity of inner ear hair cells. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4999-5008
1	J:306218 Landin Malt A, Hogan AK, Smith CD, Madani MS, Lu X, Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling. J Cell Biol. 2020 Oct 5;219(10)
2	J:308321 Lau EO, Damiani D, Chehade G, Ruiz-Reig N, Saade R, Jossin Y, Aittaleb M, Schakman O, Tajeddine N, Gailly P, Tissir F, DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. Elife. 2021 Apr 26;10:e61974
1	J:294113 Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE, Telophase correction refines division orientation in stratified epithelia. Elife. 2019 Dec 13;8:e49249
1	J:297063 Najarro EH, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG, Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. Development. 2020 Oct 5;147(19):dev191981
1	J:239604 Okamoto S, Chaya T, Omori Y, Kuwahara R, Kubo S, Sakaguchi H, Furukawa T, Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function. J Neurosci. 2017 Feb 22;37(8):2073-2085
16*	J:149860 Raji B, Dansault A, Vieira V, de la Houssaye G, Lacassagne E, Kobetz A, Arbogast L, Dufier JL, Blumer JB, Menasche M, Abitbol M, Analysis of partner of inscuteable (mPins) expression in the developing mouse eye. Mol Vis. 2008;14:2575-96
2*	J:237701 Saare M, Lulla S, Tonissoo T, Meier R, Kask K, Ruisu K, Karis A, Salumets A, Pooga M, Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS One. 2015;10(6):e0129131
1*	J:253585 Siletti K, Tarchini B, Hudspeth AJ, Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11170-E11179
3	J:271898 Tadenev ALD, Akturk A, Devanney N, Mathur PD, Clark AM, Yang J, Tarchini B, GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity. Curr Biol. 2019 Feb 19;
7	J:214064 Tarchini B, Jolicoeur C, Cayouette M, A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell. 2013 Oct 14;27(1):88-102
4*	J:169194 Walsh T, Shahin H, Elkan-Miller T, Lee MK, Thornton AM, Roeb W, Abu Rayyan A, Loulus S, Avraham KB, King MC, Kanaan M, Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet. 2010 Jul 9;87(1):90-4
3*	J:219386 Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E, Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 2014 Aug;16(8):758-69
1	J:330677 Yu D, Deng D, Chen B, Sun H, Lyu J, Zhao Y, Chen P, Wu H, Ren D, Rack1 regulates cellular patterning and polarity in the mouse cochlea. Exp Cell Res. 2022 Oct 14;421(2):113387
9*	J:82278 Yu F, Morin X, Kaushik R, Bahri S, Yang X, Chia W, A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci. 2003 Mar 1;116(Pt 5):887-96