Gene Expression Literature Summary

• Symbol: Atf6
• Name: activating transcription factor 6
• ID: MGI:1926157

41 matching records from 41 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)					1		3		3	2	3	2		5	6
In situ RNA (section)									2		1				2
In situ reporter (knock in)			1		1
Western blot	1	2		3	1	1	2	1	2	2	2	1		6	9
RT-PCR					1		2	3	5	2	2		1	4	14

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Atf6  activating transcription factor 6   (Synonyms: 9130025P16Rik, Atf6alpha, ESTM49)
Results	Reference
7*	J:294896 Aryal YP, Lee ES, Kim TY, Sung S, Kim JY, An SY, Jung JK, Ha JH, Suh JY, Yamamoto H, Sohn WJ, Cho SW, Lee Y, An CH, Kim JY, Stage-specific expression patterns of ER stress-related molecules in mice molars: Implications for tooth development. Gene Expr Patterns. 2020 Sep;37:119130
1	J:291194 Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY, An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol. 2019 Nov;234(11):20354-20365
1*	J:157050 Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lovgren-Sandblom A, Bjorkhem I, Edwards PA, Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan;51(1):169-81
1	J:349721 Borisova E, Newman AG, Couce Iglesias M, Dannenberg R, Schaub T, Qin B, Rusanova A, Brockmann M, Koch J, Daniels M, Turko P, Jahn O, Kaplan DR, Rosario M, Iwawaki T, Spahn CMT, Rosenmund C, Meierhofer D, Kraushar ML, Tarabykin V, Ambrozkiewicz MC, Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
1	J:302526 Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X, EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):31
1	J:284756 Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, Lindahl M, Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Front Endocrinol (Lausanne). 2019;10:765
5	J:158314 Firtina Z, Danysh BP, Bai X, Gould DB, Kobayashi T, Duncan MK, Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J Biol Chem. 2009 Dec 18;284(51):35872-84
11*	J:168632 Firtina Z, Duncan MK, Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):135-43
1*	J:250104 Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B, The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49
1	J:343810 Guo CG, Sun R, Wang X, Yuan Y, Xu Y, Li S, Sun X, Wang J, Hu X, Guo T, Chen XW, Xiao RP, Zhang X, Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Mol Metab. 2023 Nov 30;79:101847
6*	J:247203 Guo F, Han X, Wu Z, Cheng Z, Hu Q, Zhao Y, Wang Y, Liu C, ATF6a, a Runx2-activable transcription factor, is a new regulator of chondrocyte hypertrophy. J Cell Sci. 2016 Feb 15;129(4):717-28
5	J:270164 Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y, Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019 Jan 3;10(1):37
6	J:153222 Iwawaki T, Akai R, Yamanaka S, Kohno K, Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
3	J:333870 Jazwiec PA, Patterson VS, Ribeiro TA, Yeo E, Kennedy KM, Mathias PCF, Petrik JJ, Sloboda DM, Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biol Reprod. 2022 Aug 9;107(2):574-589
1	J:240829 Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR, Regulation of PERK-eIF2alpha signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nat Commun. 2016 Jul 15;7:12185
1	J:305864 Kalish BT, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME, Huh JR, Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021 Feb;24(2):204-213
1	J:212712 Liang G, Lian C, Huang D, Gao W, Liang A, Peng Y, Ye W, Wu Z, Su P, Huang D, Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PLoS One. 2014;9(1):e86894
2	J:211812 Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M, MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
3*	J:111577 Mao C, Tai WC, Bai Y, Poizat C, Lee AS, In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4. J Biol Chem. 2006 Mar 31;281(13):8877-87
1	J:242077 Mao M, Kiss M, Ou Y, Gould DB, Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech. 2017 Apr 01;10(4):475-485
1	J:344186 Munoz-Gallardo MDM, Garcia-Padilla C, Vicente-Garcia C, Carvajal J, Arenega A, Franco D, miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810
1*	J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12;
2	J:287361 Pakarinen E, Danilova T, Voikar V, Chmielarz P, Piepponen P, Airavaara M, Saarma M, Lindahl M, MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. eNeuro. 2020 Jan/Feb;7(1):ENEURO.0477-19.2019
2	J:327300 Pakarinen E, Lindholm P, Saarma M, Lindahl M, CDNF and MANF regulate ER stress in a tissue-specific manner. Cell Mol Life Sci. 2022 Feb 7;79(2):124
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
3	J:287101 Park S, Aintablian A, Coupe B, Bouret SG, The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates. Nat Commun. 2020 Apr 20;11(1):1914
8	J:308694 Tan YY, Zhang Y, Li B, Ou YW, Xie SJ, Chen PP, Mei SQ, Huang QJ, Zheng LL, Qu LH, PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks. Front Cell Dev Biol. 2021;9:670435
1*	J:332497 Tang X, Wei W, Snowball JM, Nakayasu ES, Bell SM, Ansong C, Lin X, Whitsett JA, EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience. 2023 Jan 20;26(1):105667
1	J:243333 Tian E, Hoffman MP, Ten Hagen KG, O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Nat Commun. 2012 May 29;3:869
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:244948 Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO, Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc. 2014 Oct 20;3(5):e001018
2	J:268286 Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV, Glucose-regulated protein 78 is essential for cardiac myocyte survival. Cell Death Differ. 2018 Dec;25(12):2181-2194
1	J:146172 Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK, Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009 Jan 12;184(1):143-58
3*	J:317048 Xiong Z, Jiang R, Zhang P, Han X, Guo FJ, Transmission of ER stress response by ATF6 promotes endochondral bone growth. J Orthop Surg Res. 2015 Sep 15;10:141
1	J:353791 Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Alexander LEC, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X, Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
1	J:326352 Yamaguchi H, Meyer MD, He L, Komatsu Y, Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice. Dev Dyn. 2022 Jul;251(7):1209-1222
1	J:344311 Yan W, Chen S, Wang Y, You Y, Lu Y, Wang W, Wu B, Du J, Peng S, Cai W, Xiao Y, Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
1*	J:272566 Yang R, Wang H, Kang B, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Xu P, Chang Y, Jia Y, Huang Y, CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
5	J:128422 Zhang X, Szabo E, Michalak M, Opas M, Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci. 2007 Nov;25(7):455-63
2	J:242134 Zhao Z, Cao L, Reece EA, Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4489-4494
1	J:286157 Zheng C, Lin X, Xu X, Wang C, Zhou J, Gao B, Fan J, Lu W, Hu Y, Jie Q, Luo Z, Yang L, Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias. EBioMedicine. 2019 Feb;40:695-709