Gene Expression Literature Summary

• Symbol: Cdon
• Name: cell adhesion molecule-related/down-regulated by oncogenes
• ID: MGI:1926387

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E6.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)	1					1	2	1		2	3	1	8	1	1	1	2	1	1		4
In situ RNA (section)				1	2	4	5	11		7	6		3	1	10		1	1	2	3	5
In situ RNA (whole mount)		1	2	2		1	3	2							1					1
In situ reporter (knock in)			1	2	1	2	1	3	1	3	5		1	1	1		1		2		1
Western blot							2	1									1		1
RT-PCR							2	1	1			1	1				2		1		2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdon  cell adhesion molecule-related/down-regulated by oncogenes   (Synonyms: CAM-related/down-regulated by oncogenes, CDO)
Results	Reference
2*	J:173604 Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP, Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87
2*	J:294897 Ankamreddy H, Koo H, Lee YJ, Bok J, CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development. Dev Dyn. 2020 Sep;249(9):1117-1126
1	J:289968 Bae J-H, Hong M, Jeong H-J, Kim H, Lee S-J, Ryu D, Bae G-U, Cho SC, Lee Y-S, Krauss RS, Kang J-S, Satellite Cell-Specific Ablation of Cdon Impairs Integrin Activation, FGF Signalling, and Muscle Regeneration. J Cachexia Sarcopenia Muscle. 2020;
3	J:238712 Belanger MC, Robert B, Cayouette M, Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals. Dev Cell. 2017 Jan 23;40(2):137-150
2	J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600
4*	J:267598 Castiglioni I, Caccia R, Garcia-Manteiga JM, Ferri G, Caretti G, Molineris I, Nishioka K, Gabellini D, The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression. Nat Commun. 2018 Nov 28;9(1):5026
2	J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
2	J:239874 Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE, LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48
3*	J:82221 Cole F, Krauss RS, Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5
1	J:271140 Diacou R, Zhao Y, Zheng D, Cvekl A, Liu W, Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation. Cell Rep. 2018 Nov 27;25(9):2510-2523.e4
3	J:304642 Dupacova N, Antosova B, Paces J, Kozmik Z, Meis homeobox genes control progenitor competence in the retina. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2013136118
3	J:300506 Echevarria-Andino ML, Allen BL, The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020 Dec 14;147(23):dev189076
8*	J:330830 Echevarria-Andino ML, Franks NE, Schrader HE, Hong M, Krauss RS, Allen BL, CDON contributes to Hedgehog-dependent patterning and growth of the developing limb. Dev Biol. 2022 Oct 17;493:1-11
2	J:157640 Fabre PJ, Shimogori T, Charron F, Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. J Neurosci. 2010 Jan 6;30(1):266-75
1*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:278245 Guo Q, Li JYH, Defining developmental diversification of diencephalon neurons through single cell gene expression profiling. Development. 2019 Apr 1;146(12):dev174284
2	J:193728 Hong M, Krauss RS, Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet. 2012;8(10):e1002999
4	J:173603 Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F, Boc and gas1 each form distinct shh receptor complexes with ptch1 and are required for shh-mediated cell proliferation. Dev Cell. 2011 Jun 14;20(6):788-801
4	J:251202 Jeong MH, Leem YE, Kim HJ, Kang K, Cho H, Kang JS, A Shh coreceptor Cdo is required for efficient cardiomyogenesis of pluripotent stem cells. J Mol Cell Cardiol. 2016 Apr;93:57-66
4	J:218163 Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M, Fan CM, Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80
1	J:334107 Jin Y, Gao X, Lu M, Chen G, Yang X, Ren N, Song Y, Hou C, Li J, Liu Q, Gao J, Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice. Hum Mol Genet. 2022 Oct 10;31(20):3504-3520
1	J:315774 Junker JP, Peterson KA, Nishi Y, Mao J, McMahon AP, van Oudenaarden A, A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell. 2014 Nov 24;31(4):448-60
2	J:354453 Kim JM, Min KW, Kim YJ, Smits R, Basler K, Kim JW, Wnt/beta-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium. Mol Cells. 2023 Jul 31;46(7):441-450
3	J:291852 Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH, Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020 Apr 24;11(1):1994
5	J:346064 Leung AOW, Poon ACH, Wang X, Feng C, Chen P, Zheng Z, To MK, Chan WCW, Cheung M, Chan D, Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1. Nat Commun. 2024 Mar 12;15(1):2229
4	J:299678 Li H, Zhu Y, Morozov YM, Chen X, Page SC, Rannals MD, Maher BJ, Rakic P, Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities. Mol Psychiatry. 2019 Aug;24(8):1235-1246
6	J:332136 Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP, Wallace V, Blackshaw S, Li P, Levine EM, Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis. Elife. 2022 Dec 2;11
1	J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*	J:102872 McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A, Soares MB, Bonaldo Mde F, Grimmond S, Hui CC, Wainwright B, Wicking C, Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev. 2005 Nov;122(11):1218-33
2	J:253963 Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW, Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Dev Cell. 2018 Jan 8;44(1):13-28.e3
15*	J:64540 Mulieri PJ, Okada A, Sassoon DA, McConnell SK, Krauss RS, Developmental expression pattern of the cdo gene. Dev Dyn. 2000 Sep;219(1):40-9
4	J:115577 Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK, Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
1	J:284130 Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT, Iseki S, Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development. 2019 Nov 12;146(21):dev180075
2	J:335153 Qiu T, Huteckova B, Seppala M, Cobourne MT, Chen Z, Hovorakova M, Buchtova M, Tucker AS, Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464
1	J:280142 Quintana-Urzainqui I, Kozic Z, Mitra S, Tian T, Manuel M, Mason JO, Price DJ, Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent. iScience. 2018 Dec 21;10:171-191
1	J:198426 Sanchez-Arrones L, Nieto-Lopez F, Sanchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P, Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina. J Neurosci. 2013 May 15;33(20):8596-607
4*	J:335331 Seppala M, Thivichon-Prince B, Xavier GM, Shaffie N, Sangani I, Birjandi AA, Rooney J, Lau JNS, Dhaliwal R, Rossi O, Riaz MA, Stonehouse-Smith D, Wang Y, Papageorgiou SN, Viriot L, Cobourne MT, Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog. J Dent Res. 2022 Apr;101(4):473-482
4	J:216223 Seppala M, Xavier GM, Fan CM, Cobourne MT, Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function. Biol Open. 2014;3(8):728-40
5*	J:252976 Shin JO, Ankamreddy H, Jakka NM, Lee S, Kim UK, Bok J, Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol. 2017;61(8-9):557-563
3	J:277380 Telley L, Agirman G, Prados J, Amberg N, Fievre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D, Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440)
8	J:108747 Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP, The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006 May;10(5):647-56
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:237790 Verwey M, Grant A, Meti N, Adye-White L, Torres-Berrio A, Rioux V, Levesque M, Charron F, Flores C, Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon. eNeuro. 2016 May-Jun;3(3):ENEURO.0009-16.2016
1*	J:310323 Vied CM, Freudenberg F, Wang Y, Raposo AA, Feng D, Nowakowski RS, A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Front Neurosci. 2014;8:257
1	J:108746 Zhang W, Kang JS, Cole F, Yi MJ, Krauss RS, Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell. 2006 May;10(5):657-65
4	J:156965 Zhang W, Mulieri PJ, Gaio U, Bae GU, Krauss RS, Kang JS, Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. FEBS J. 2009 Oct;276(20):5998-6010
2	J:109070 Zhang W, Yi MJ, Chen X, Cole F, Krauss RS, Kang JS, Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO. Mol Cell Biol. 2006 May;26(10):3764-72