Gene Expression Literature Summary

• Symbol: Sp5
• Name: trans-acting transcription factor 5
• ID: MGI:1927715

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E18.5	E	P
Immunohistochemistry (section)																	1
In situ RNA (section)			1		1		5		4	2	2	1	1		3		1	1	5	2	1			1
In situ RNA (whole mount)	1	1	3	2	5	4	8	2	4	3	2	1	1	3	1		2	1	3		1		1
In situ reporter (knock in)															1	1								1
RT-PCR							1		1		1		2		2				1	1		1		5
cDNA clones							1																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sp5  trans-acting transcription factor 5
Results	Reference
1	J:135132 Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP, Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
1	J:181005 Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP, HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development. 2011 Nov;138(22):4931-42
2	J:214677 Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A, Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. Dev Biol. 2014 Jul 1;391(1):54-65
2	J:193325 Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
2	J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600
1	J:236315 Chalamalasetty RB, Ajima R, Garriock RJ, Kennedy MW, Tessarollo L, Yamaguchi TP, A new gain-of-function mouse line to study the role of Wnt3a in development and disease. Genesis. 2016 Sep;54(9):497-502
1	J:205649 Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP, The Wnt3a/beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011;2:390
4	J:171275 Cho SW, Kwak S, Woolley TE, Lee MJ, Kim EJ, Baker RE, Kim HJ, Shin JS, Tickle C, Maini PK, Jung HS, Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development. 2011 May;138(9):1807-16
2*	J:177793 Combes AN, Bowles J, Feng CW, Chiu HS, Khoo PL, Jackson A, Little MH, Tam PP, Koopman P, Expression and functional analysis of Dkk1 during early gonadal development. Sex Dev. 2011;5(3):124-30
1*	J:116164 Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquie O, A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science. 2006 Dec 8;314(5805):1595-8
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:274335 Draganova K, Zemke M, Zurkirchen L, Valenta T, Cantu C, Okoniewski M, Schmid MT, Hoffmans R, Gotz M, Basler K, Sommer L, Wnt/beta-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells. 2015 Jan;33(1):170-82
4*	J:286213 Dunty WC Jr, Kennedy MW, Chalamalasetty RB, Campbell K, Yamaguchi TP, Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/beta-catenin pathway in neuromesodermal stem cells. PLoS One. 2014;9(1):e87018
1	J:160589 Freyer L, Morrow BE, Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle. Dev Dyn. 2010 Jun;239(6):1708-22
1	J:291490 Garriock RJ, Chalamalasetty RB, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP, A dorsal-ventral gradient of Wnt3a/beta-catenin signals controls mouse hindgut extension and colon formation. Development. 2020 Apr 12;147(8):dev185108
1	J:187047 Gerber SD, Amann R, Wyder S, Trueb B, Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. PLoS One. 2012;7(3):e33457
1	J:221338 Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F, The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
20*	J:65743 Harrison SM, Houzelstein D, Dunwoodie SL, Beddington RS, Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
1	J:203028 Hasenpusch-Theil K, Magnani D, Amaniti EM, Han L, Armstrong D, Theil T, Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex. 2012 Dec;22(12):2878-93
1	J:309618 Jiang M, Yu D, Xie B, Huang H, Lu W, Qiu M, Dai ZM, WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression. Mol Brain. 2020 Nov 13;13(1):155
1*	J:304253 Jones MR, Dilai S, Lingampally A, Chao CM, Danopoulos S, Carraro G, Mukhametshina R, Wilhelm J, Baumgart-Vogt E, Al Alam D, Chen C, Minoo P, Zhang JS, Bellusci S, A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746
1	J:232050 Kennedy MW, Chalamalasetty RB, Thomas S, Garriock RJ, Jailwala P, Yamaguchi TP, Sp5 and Sp8 recruit beta-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3545-50
1	J:176833 Kim TH, Shivdasani RA, Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11;208(4):677-88
1	J:227517 Koizumi M, Oyama K, Yamakami Y, Kida T, Satoh R, Kato S, Hidema S, Oe T, Goto T, Clevers H, Nawa A, Nishimori K, Lgr4 controls specialization of female gonads in mice. Biol Reprod. 2015 Oct;93(4):90
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:285409 Li Y, Jiao J, Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. Sci Adv. 2020 Jan;6(1):eaay6350
1*	J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
2	J:143586 Manuylov NL, Smagulova FO, Leach L, Tevosian SG, Ovarian development in mice requires the GATA4-FOG2 transcription complex. Development. 2008 Nov;135(22):3731-43
2	J:235736 Masek J, Machon O, Korinek V, Taketo MM, Kozmik Z, Tcf7l1 protects the anterior neural fold from adopting the neural crest fate. Development. 2016 Jun 15;143(12):2206-16
1	J:324116 Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H, Tracing the origin of hair follicle stem cells. Nature. 2021 Jun;594(7864):547-552
1	J:170831 Naiche LA, Holder N, Lewandoski M, FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4018-23
1	J:234178 Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E, Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016 Jul;12(7):e1006151
1	J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
5*	J:160652 Sahara S, Kawakami Y, Izpisua Belmonte JC, O'Leary DD, Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev. 2007;2:10
2	J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
1*	J:338194 Sulic AM, Das Roy R, Papagno V, Lan Q, Saikkonen R, Jernvall J, Thesleff I, Mikkola ML, Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643
1*	J:324832 Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W, Liu Z, Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
2*	J:192194 Tortelote GG, Hernandez-Hernandez JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Perez JA, Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 1;374(1):164-73
13*	J:68162 Treichel D, Becker M, Gruss P, The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesis. Mech Dev. 2001 Mar;101(1-2):175-9
1	J:141958 Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA, Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling. Nat Genet. 2008 Sep 1;40(9):1130-5
1*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*	J:119277 Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ, Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. J Neurochem. 2006 Aug;98(3):860-75
4	J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72
2*	J:352711 Zhao R, Moore EL, Gogol MM, Unruh JR, Yu Z, Scott AR, Wang Y, Rajendran NK, Trainor PA, Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Elife. 2024 Jun 14;13