Symbol Name ID |
Mtor
mechanistic target of rapamycin kinase MGI:1928394 |
Age | E0.5 | E1 | E1.5 | E2 | E2.5 | E3 | E3.5 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E16.5 | E17.5 | E18.5 | E19.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 4 | 5 | 1 | 4 | 1 | 2 | 11 | ||||||||
In situ RNA (section) | 2 | 1 | 2 | 1 | 2 | |||||||||||||||||||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | |||||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | ||||||||||||||||||||||||
Western blot | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 4 | 5 | 1 | 6 | 2 | 2 | 5 | 4 | 2 | 2 | 1 | 2 | 36 | ||||
RT-PCR | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 5 |
Mtor mechanistic target of rapamycin kinase (Synonyms: 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase), RAFT1, RAPT1) | |
Results | Reference |
1 | J:213136 Baker MD, Ezzati M, Aloisio GM, Tarnawa ED, Cuevas I, Nakada Y, Castrillon DH, The small GTPase Rheb is required for spermatogenesis but not oogenesis. Reproduction. 2014 May;147(5):615-25 |
1* | J:130984 Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I, A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):270-5 |
1 | J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068 |
1* | J:236179 Bowman CE, Zhao L, Hartung T, Wolfgang MJ, Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104 |
3* | J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167 |
1 | J:334838 Chang JH, Chou CH, Wu JC, Liao KM, Luo WJ, Hsu WL, Chen XR, Yu SL, Pan SH, Yang PC, Su KY, LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway. Commun Biol. 2023 Apr 10;6(1):389 |
1 | J:272052 Cheng X, Ma X, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q, Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell. 2019 Feb 21;73(4):788-802.e7 |
1 | J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502 |
1 | J:281393 Chung C, Ha S, Kang H, Lee J, Um SM, Yan H, Yoo YE, Yoo T, Jung H, Lee D, Lee E, Lee S, Kim J, Kim R, Kwon Y, Kim W, Kim H, Duffney L, Kim D, Mah W, Won H, Mo S, Kim JY, Lim CS, Kaang BK, Boeckers TM, Chung Y, Kim H, Jiang YH, Kim E, Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2(-/-) Mice. Biol Psychiatry. 2019 Apr 1;85(7):534-543 |
1 | J:228212 Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C, FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5 |
1 | J:197151 Cloetta D, Thomanetz V, Baranek C, Lustenberger RM, Lin S, Oliveri F, Atanasoski S, Ruegg MA, Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013 May 1;33(18):7799-810 |
1 | J:246667 Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC, Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS One. 2017;12(2):e0171268 |
2 | J:242729 Ding X, Bloch W, Iden S, Ruegg MA, Hall MN, Leptin M, Partridge L, Eming SA, mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226 |
1* | J:224837 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP, Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9 |
1 | J:242328 Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, Spassky N, mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017 Jan 15;144(2):201-210 |
1 | J:290269 Garg A, Hannan A, Wang Q, Makrides N, Zhong J, Li H, Yoon S, Mao Y, Zhang X, Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. Elife. 2020 Feb 11;9:e51915 |
3 | J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624 |
1 | J:137592 Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71 |
2 | J:190992 Harmelink C, Peng Y, DeBenedittis P, Chen H, Shou W, Jiao K, Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013 Jan 1;373(1):53-63 |
2* | J:154667 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM, Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7 |
3 | J:235665 He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A, Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47 |
4 | J:94381 Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS, FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13796-801 |
2 | J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162 |
2 | J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120 |
2 | J:256299 Hughes J, Dawson R, Tea M, McAninch D, Piltz S, Jackson D, Stewart L, Ricos MG, Dibbens LM, Harvey NL, Thomas P, Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. Sci Rep. 2017 Oct 3;7(1):12618 |
1 | J:114455 Ismat FA, Xu J, Lu MM, Epstein JA, The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest. 2006 Sep;116(9):2378-84 |
2* | J:153715 Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ, Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56 |
5 | J:217495 Ka M, Condorelli G, Woodgett JR, Kim WY, mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development. 2014 Nov;141(21):4076-86 |
1 | J:249035 Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M, McGillewie L, Bar S, Minocha S, Chevalier C, Po C, Chelly J, Mandel JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, Herault Y, Collins SC, Friant S, Godin JD, Yalcin B, WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317 |
1 | J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748 |
1 | J:211789 Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A, Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39 |
3 | J:321519 Kelam N, Racetin A, Katsuyama Y, Vukojevic K, Kostic S, Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. Int J Mol Sci. 2022 Feb 11;23(4) |
1 | J:302544 Kimura T, Saito H, Kawasaki M, Takeichi M, CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains. Development. 2021 Feb 5;148(3):dev195073 |
1 | J:332423 Kong X, Shu X, Wang J, Liu D, Ni Y, Zhao W, Wang L, Gao Z, Chen J, Yang B, Guo X, Wang Z, Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Development. 2022 Dec 15;149(24):dev201286 |
4* | J:170203 Lague MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D, Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E936-46 |
1 | J:202964 Lai LP, Lilley BN, Sanes JR, McMahon AP, Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19450-5 |
1 | J:154054 Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R, Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 15;461(7266):1002-6 |
1 | J:224980 Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR, Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054 |
1 | J:312817 Lei X, Jiao J, UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling. Stem Cell Reports. 2018 Apr 10;10(4):1193-1207 |
1 | J:301834 Li G, Xu C, Lin X, Qu L, Xia D, Hongdu B, Xia Y, Wang X, Lou Y, He Q, Ma D, Chen Y, Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality. Cell Death Dis. 2017 May 25;8(5):e2811 |
1 | J:301660 Li M, Lu G, Hu J, Shen X, Ju J, Gao Y, Qu L, Xia Y, Chen Y, Bai Y, EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports. 2016 Mar 8;6(3):396-410 |
2 | J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41 |
7* | J:308879 Li Y, Tang J, Ji X, Hua MM, Liu M, Chang L, Gu Y, Shi C, Ni W, Liu J, Shi HJ, Huang X, O'Neill C, Jin X, Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E. Development. 2021 Jun 15;148(12):dev190793 |
2* | J:238260 Liu TY, Chen YC, Jong YJ, Tsai HJ, Lee CC, Chang YS, Chang JG, Chang YF, Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017 Jan;7(1) |
2 | J:333829 Lopez-Tello J, Sferruzzi-Perri AN, Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770 |
3* | J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86 |
1 | J:177840 Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcia-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R, Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions. Cell Stem Cell. 2011 Nov 4;9(5):447-62 |
1 | J:201333 Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R, Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. Dis Model Mech. 2013 Sep-Oct;6(5):1185-97 |
5 | J:171254 Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI, Fbxw7-dependent Degradation of Notch Is Required for Control of 'Stemness' and Neuronal-Glial Differentiation in Neural Stem Cells. J Biol Chem. 2011 Apr 15;286(15):13754-64 |
2 | J:310865 Merech F, Hauk V, Paparini D, Fernandez L, Naguila Z, Ramhorst R, Waschek J, Perez Leiros C, Vota D, Growth impairment, increased placental glucose uptake and altered transplacental transport in VIP deficient pregnancies: Maternal vs. placental contributions. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166207 |
1 | J:309998 Nie X, Ricupero CL, Jiao K, Yang P, Mao JJ, mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway. Dev Biol. 2021 Sep;477:241-250 |
3* | J:297164 Nie X, Zheng J, Cruciger M, Yang P, Mao JJ, mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87 |
6 | J:263684 Nie X, Zheng J, Ricupero CL, He L, Jiao K, Mao JJ, mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491 |
1 | J:213126 O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14 |
1 | J:303303 Pan M, Yin Y, Wang X, Wang Q, Zhang L, Hu H, Wang C, Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Autophagy. 2020 Aug 2;:1-16 |
2 | J:312376 Pastar V, Lozic M, Kelam N, Filipovic N, Bernard B, Katsuyama Y, Vukojevic K, Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. Int J Mol Sci. 2021 Oct 2;22(19) |
1 | J:311917 Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, Zhang Y, Lu K, He F, Zhang L, NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016 May 24;7(21):31440-53 |
1 | J:346063 Rehmani T, Dias AP, Kamal M, Salih M, Tuana BS, Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway. Int J Mol Sci. 2024 Mar 1;25(5) |
1 | J:161417 Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE, The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development. Dev Biol. 2010 Jun 15;342(2):146-56 |
1 | J:149460 Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A, Komori T, Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol. 2009 Apr 1;328(1):78-93 |
1 | J:269511 Roy A, Skibo J, Kalume F, Ni J, Rankin S, Lu Y, Dobyns WB, Mills GB, Zhao JJ, Baker SJ, Millen KJ, Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. Elife. 2015 Dec 3;4:e12703 |
3 | J:325114 Serra I, Stravs A, Osorio C, Oyaga MR, Schonewille M, Tudorache C, Badura A, Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum. Front Mol Neurosci. 2022;15:831687 |
2 | J:347601 Shen T, Wang S, Huang C, Zhu S, Zhu X, Li N, Wang H, Huang L, Ren M, Han Z, Ge J, Chen Z, Ouyang K, Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 2024 May 28;710:149883 |
1 | J:241448 Shin JY, Mendez-Lopez I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ, Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Hum Mol Genet. 2017 Jan 01;26(1):65-78 |
2 | J:119564 Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA, Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell. 2006 Oct;11(4):583-9 |
2 | J:242899 Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM, Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development. 2017 Jul 01;144(13):2402-2414 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1 | J:121697 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA, Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31 |
1 | J:284292 Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X, Zheng Y, Sun M, Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 1;9(5):520 |
1 | J:314221 Wang Q, Tao C, Hannan A, Yoon S, Min X, Peregrin J, Qu X, Li H, Yu H, Zhao J, Zhang X, Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling. Sci Adv. 2021 Jun;7(27) |
5* | J:205532 Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z, Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013 Nov 7;13(5):617-25 |
1 | J:306367 Wei R, Qiu X, Wang S, Li Y, Wang Y, Lu K, Fu Y, Xing G, He F, Zhang L, NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell Signal. 2015 Mar;27(3):578-86 |
1* | J:187480 Westendorp B, Major JL, Nader M, Salih M, Leenen FH, Tuana BS, The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012 Jun;26(6):2569-79 |
2 | J:326953 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G, Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Rep. 2022 Jul 19;40(3):111085 |
1 | J:151770 Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 2009 Oct;52(10):2130-41 |
1 | J:244710 Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI, FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017 Apr 15;37(8) |
2* | J:113443 Yang Q, Inoki K, Ikenoue T, Guan KL, Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15;20(20):2820-32 |
2 | J:310855 Yiu JHC, Cheung SWM, Cai J, Chan KS, Chen J, Cheong LY, Chau HT, Xu A, Li RHW, Woo CW, TLR5 Supports Development of Placental Labyrinthine Zone in Mice. Front Cell Dev Biol. 2021;9:711253 |
7* | J:304555 Zamfirescu RC, Day ML, Morris MB, mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition. Am J Physiol Cell Physiol. 2021 Jan 1;320(1):C30-C44 |
2 | J:242134 Zhao Z, Cao L, Reece EA, Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4489-4494 |
1 | J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988 |
1 | J:335524 Zhu S, Nguyen A, Pang J, Zhao J, Chen Z, Liang Z, Gu Y, Huynh H, Bao Y, Lee S, Kluger Y, Ouyang K, Evans SM, Fang X, Mitochondrial Stress Induces an HRI-eIF2alpha Pathway Protective for Cardiomyopathy. Circulation. 2022 Sep 27;146(13):1028-1031 |
6 | J:195854 Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED, Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221 |
1 | J:344234 Zou W, Lv Y, Zhang S, Li L, Sun L, Jiao J, Lysosomal dynamics regulate mammalian cortical neurogenesis. Dev Cell. 2024 Jan 8;59(1):64-78.e5 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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