Gene Expression Literature Summary

• Symbol: Mbnl1
• Name: muscleblind like splicing regulator 1
• ID: MGI:1928482

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E5.5	E6.5	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)											1				1															1		2
In situ RNA (section)																			1		1			1	1		1					2
In situ RNA (whole mount)									1			1	2	1					1				2								1
Northern blot						1	1	1	1	1		1	1		1		1		1		1	1	1		1	1	1	1				2
Western blot														1				1	1	1		2	1				1	1	1			9
RT-PCR	1	1	1	1	1	1					2	1				1			2	2			2	1			1	2				8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mbnl1  muscleblind like splicing regulator 1   (Synonyms: mKIAA0428)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2*	J:256956 Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA, Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6:e27192
3*	J:187997 Chamberlain CM, Ranum LP, Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise. Hum Mol Genet. 2012 Nov 1;21(21):4645-54
6	J:239862 Coram RJ, Stillwagon SJ, Guggilam A, Jenkins MW, Swanson MS, Ladd AN, Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev Biol. 2015 Oct 15;15:36
2	J:329983 Fidalgo MF, Fonseca CG, Caldas P, Raposo AA, Balboni T, Henao-Misikova L, Grosso AR, Vasconcelos FF, Franco CA, Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes. Life Sci Alliance. 2022 Dec;5(12):e202201554
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
6	J:284259 Hung CS, Lin JC, Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis. Biochim Biophys Acta Gene Regul Mech. 2020 Jan;1863(1):194437
4*	J:142671 Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA, A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20333-8
23*	J:85713 Kanadia RN, Urbinati CR, Crusselle VJ, Luo D, Lee YJ, Harrison JK, Oh SP, Swanson MS, Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3. Gene Expr Patterns. 2003 Aug;3(4):459-62
2	J:98810 Ladd AN, Stenberg MG, Swanson MS, Cooper TA, Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev Dyn. 2005 Apr 13;233(3):783-793
3	J:286293 Li M, Zhuang Y, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W, HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5472-5477
3	J:112061 Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA, Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet. 2006 Jul 1;15(13):2087-97
4	J:338401 Nutter CA, Kidd BM, Carter HA, Hamel JI, Mackie PM, Kumbkarni N, Davenport ML, Tuyn DM, Gopinath A, Creigh PD, Sznajder LJ, Wang ET, Ranum LPW, Khoshbouei H, Day JW, Sampson JB, Prokop S, Swanson MS, Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1. Brain. 2023 May 5;
7	J:199127 Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB, Swanson MS, Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Hum Mol Genet. 2013 Sep 1;22(17):3547-58
1*	J:130143 Redmond LC, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells. Dev Dyn. 2008 Feb;237(2):436-46
4*	J:167108 Terenzi F, Ladd AN, Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity. RNA Biol. 2010 Jan-Feb;7(1):43-55
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:225638 Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A, Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet. 2004 Jul 15;13(14):1487-503