Gene Expression Literature Summary

• Symbol: Setdb1
• Name: SET domain, bifurcated 1
• ID: MGI:1934229

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E7.5	E8.5	E9.5	E10	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)												1	1		1	3			1		4	1			2
In situ RNA (section)									1			2	1			1		3			1				1
Immunohistochemistry (whole mount)	2				1
In situ RNA (whole mount)									1			1
In situ reporter (knock in)		1	1	1		1	2	2	2																1
Northern blot																									1
Western blot											1		1	1		2	1	1		1	1	1			2
RT-PCR										1			1					2	2		1	2	1	1	3
cDNA clones																									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Setdb1  SET domain, bifurcated 1   (Synonyms: ESET, KMT1E, mKIAA0067)
Results	Reference
5	J:173973 Benlhabib H, Mendelson CR, Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol Cell Biol. 2011 May;31(10):1949-58
1*	J:106181 Chiellini C, Costa M, Novelli SE, Amri EZ, Benzi L, Bertacca A, Cohen P, Del Prato S, Friedman JM, Maffei M, Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol. 2003 May;195(2):309-21
3*	J:183927 Cho S, Park JS, Kwon S, Kang YK, Dynamics of Setdb1 expression in early mouse development. Gene Expr Patterns. 2012 May;12(5-6):213-8
1	J:201508 Daxinger L, Harten SK, Oey H, Epp T, Isbel L, Huang E, Whitelaw N, Apedaile A, Sorolla A, Yong J, Bharti V, Sutton J, Ashe A, Pang Z, Wallace N, Gerhardt DJ, Blewitt ME, Jeddeloh JA, Whitelaw E, An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
8	J:89058 Dodge JE, Kang YK, Beppu H, Lei H, Li E, Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol. 2004 Mar;24(6):2478-86
1	J:310903 Gresakova V, Novosadova V, Prochazkova M, Prochazka J, Sedlacek R, Dual role of Fam208a during zygotic cleavage and early embryonic development. Exp Cell Res. 2021 Sep 15;406(2):112723
4*	J:194983 Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K, Nifuji A, Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90
10	J:178512 Jiang Y, Matevossian A, Guo Y, Akbarian S, Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun;60(7-8):1088-97
1	J:204893 Lawson KA, Teteak CJ, Zou J, Hacquebord J, Ghatan A, Zielinska-Kwiatkowska A, Fernandes RJ, Chansky HA, Yang L, Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem. 2013 Nov 8;288(45):32119-25
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:255491 Matsuura T, Miyazaki S, Miyazaki T, Tashiro F, Miyazaki JI, Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin. Sci Rep. 2017 Sep 29;7(1):12462
3*	J:179668 Mysliwiec MR, Carlson CD, Tietjen J, Hung H, Ansari AZ, Lee Y, Jarid2 (Jumonji, AT Rich Interactive Domain 2) Regulates NOTCH1 Expression via Histone Modification in the Developing Heart. J Biol Chem. 2012 Jan 6;287(2):1235-41
1	J:159133 Shirato H, Ogawa S, Nakajima K, Inagawa M, Kojima M, Tachibana M, Shinkai Y, Takeuchi T, A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem. 2009 Jan 9;284(2):733-9
1	J:352720 Takagiwa Y, Higashihori N, Kano S, Moriyama K, Roles of the histone methyltransferase SET domain bifurcated 1 in epithelial cells during tooth development. Arch Oral Biol. 2024 Sep;165:106026
13	J:188109 Tan SL, Nishi M, Ohtsuka T, Matsui T, Takemoto K, Kamio-Miura A, Aburatani H, Shinkai Y, Kageyama R, Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development. 2012 Oct;139(20):3806-16
2	J:317815 Thiha P, Higashihori N, Kano S, Moriyama K, Histone methyltransferase SET domain bifurcated 1 negatively regulates parathyroid hormone/parathyroid hormone-related peptide receptor to control chondrocyte proliferation in Meckel's cartilage. Arch Oral Biol. 2021 Nov;131:105251
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4	J:328945 Wang Z, Fan R, Russo A, Cernilogar FM, Nuber A, Schirge S, Shcherbakova I, Dzhilyanova I, Ugur E, Anton T, Richter L, Leonhardt H, Lickert H, Schotta G, Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm. Nat Commun. 2022 Sep 19;13(1):5447
1	J:257670 Yang L, Gee AO, Zielinska-Kwiatkowska A, Chansky HA, Generation and characterization of mice with mesenchyme-specific deletion of the entire ESET histone methyltransferase protein. Genesis. 2018 Feb;56(2)
3*	J:199592 Yang L, Lawson KA, Teteak CJ, Zou J, Hacquebord J, Patterson D, Ghatan AC, Mei Q, Zielinska-Kwiatkowska A, Bain SD, Fernandes RJ, Chansky HA, ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates. Dev Biol. 2013 Aug 1;380(1):99-110
1	J:276738 Zeng TB, Han L, Pierce N, Pfeifer GP, Szabo PE, EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10834-10841