Symbol Name ID |
Pard3
par-3 family cell polarity regulator MGI:2135608 |
Age | E0.5 | E3.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E | P |
Immunohistochemistry (section) | 2 | 4 | 2 | 7 | 7 | 2 | 8 | 1 | 16 | 2 | 13 | 2 | 19 | 1 | 13 | 3 | 11 | 2 | 7 | 1 | 9 | 1 | 4 | 21 | |||||
In situ RNA (section) | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | |||||||||||||||||||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | |||||||||||||||
In situ reporter (knock in) | 1 | ||||||||||||||||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | |||||||||||||||||||||||||
Western blot | 1 | 3 | 1 | 3 | 1 | 2 | 1 | 4 | 3 | 2 | 3 | 2 | 2 | 2 | 11 | ||||||||||||||
RT-PCR | 1 | 1 | 1 | ||||||||||||||||||||||||||
cDNA clones | 1 |
Pard3 par-3 family cell polarity regulator (Synonyms: ASIP, D8Ertd580e, Par3, PAR-3, Pard3a) | |
Results | Reference |
1 | J:240005 Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA, Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 01;142(23):4092-106 |
1* | J:191149 Alves CH, Sanz Sanz A, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J, Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50 |
3 | J:178696 Asami M, Pilz GA, Ninkovic J, Godinho L, Schroeder T, Huttner WB, Gotz M, The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development. 2011 Dec;138(23):5067-78 |
2 | J:260459 Azizoglu DB, Braitsch C, Marciano DK, Cleaver O, Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390 |
1 | J:239796 Badouel C, Zander MA, Liscio N, Bagherie-Lachidan M, Sopko R, Coyaud E, Raught B, Miller FD, McNeill H, Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development. 2015 Aug 15;142(16):2781-91 |
1 | J:336187 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O, Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
1 | J:263981 Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI, Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 Apr 30;145(9):dev162123 |
1* | J:145755 Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE, Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar;296(3):F564-74 |
2 | J:154949 Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH, Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009 Jul 30;63(2):189-202 |
1 | J:302526 Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X, EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):31 |
2 | J:113146 Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Gotz M, The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci. 2006 Sep;9(9):1099-107 |
1 | J:182669 Cappello S, Bohringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Gotz M, A radial glia-specific role of RhoA in double cortex formation. Neuron. 2012 Mar 8;73(5):911-24 |
4 | J:206193 Castelli M, Boca M, Chiaravalli M, Ramalingam H, Rowe I, Distefano G, Carroll T, Boletta A, Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun. 2013;4:2658 |
2 | J:228786 Charrier LE, Loie E, Laprise P, Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep. 2015;5:17699 |
1 | J:175551 Chilov D, Sinjushina N, Rita H, Taketo MM, Makela TP, Partanen J, Phosphorylated beta-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Dev Biol. 2011 Sep 1;357(1):259-68 |
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1 | J:306166 Flasse L, Yennek S, Cortijo C, Barandiaran IS, Kraus MR, Grapin-Botton A, Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity. Cell Rep. 2020 May 26;31(8):107677 |
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1 | J:304603 Fujita I, Shitamukai A, Kusumoto F, Mase S, Suetsugu T, Omori A, Kato K, Abe T, Shioi G, Konno D, Matsuzaki F, Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development. Nat Cell Biol. 2020 Jan;22(1):26-37 |
1 | J:206576 Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y, Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409 |
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1 | J:337476 Gredler ML, Zallen JA, Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm. Dev Cell. 2023 Jun 5;58(11):933-950.e5 |
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1 | J:220469 Grego-Bessa J, Hildebrand J, Anderson KV, Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14 |
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1 | J:140256 Hartleben B, Schweizer H, Lubben P, Bartram MP, Moller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB, Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008 Aug 22;283(34):23033-8 |
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2 | J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162 |
3 | J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98 |
4 | J:331486 Hirose T, Sugitani Y, Kurihara H, Kazama H, Kusaka C, Noda T, Takahashi H, Ohno S, PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. Development. 2022 Nov 1;149(21):dev199931 |
2 | J:289439 Houssin NS, Martin JB, Coppola V, Yoon SO, Plageman TF Jr, Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination. Dev Biol. 2020 Jun 1;462(1):36-49 |
1 | J:122204 Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S, Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development. 2006 May;133(9):1735-44 |
2 | J:334107 Jin Y, Gao X, Lu M, Chen G, Yang X, Ren N, Song Y, Hou C, Li J, Liu Q, Gao J, Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice. Hum Mol Genet. 2022 Oct 10;31(20):3504-3520 |
1 | J:304136 Journiac N, Gilabert-Juan J, Cipriani S, Benit P, Liu X, Jacquier S, Faivre V, Delahaye-Duriez A, Csaba Z, Hourcade T, Melinte E, Lebon S, Violle-Poirsier C, Oury JF, Adle-Biassette H, Wang ZQ, Mani S, Rustin P, Gressens P, Nardelli J, Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly. Cell Rep. 2020 Apr 14;31(2):107506 |
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1 | J:193056 Kechad A, Jolicoeur C, Tufford A, Mattar P, Chow RW, Harris WA, Cayouette M, Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina. J Neurosci. 2012 Nov 28;32(48):17197-210 |
3* | J:242842 Kharfallah F, Guyot MC, El Hassan AR, Allache R, Merello E, De Marco P, Di Cristo G, Capra V, Kibar Z, Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization. Hum Mol Genet. 2017 Jun 15;26(12):2307-2320 |
2 | J:211342 Kielar M, Tuy FP, Bizzotto S, Lebrand C, de Juan Romero C, Poirier K, Oegema R, Mancini GM, Bahi-Buisson N, Olaso R, Le Moing AG, Boutourlinsky K, Boucher D, Carpentier W, Berquin P, Deleuze JF, Belvindrah R, Borrell V, Welker E, Chelly J, Croquelois A, Francis F, Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Nat Neurosci. 2014 Jul;17(7):923-33 |
1* | J:220858 Kim JY, Song JY, Karnam S, Park JY, Lee JJ, Kim S, Cho SH, Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. Gene Expr Patterns. 2015 Jan;17(1):31-7 |
2 | J:306060 Kindt KS, Akturk A, Jarysta A, Day M, Beirl A, Flonard M, Tarchini B, EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia. Nat Commun. 2021 May 17;12(1):2861 |
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1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
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1 | J:306851 Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, Harada A, SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity. J Cell Biol. 2021 Jan 4;220(1) |
1 | J:168023 Lahti L, Saarimaki-Vire J, Rita H, Partanen J, FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev Biol. 2011 Jan 15;349(2):270-82 |
1 | J:178681 Lakoma J, Garcia-Alonso L, Luque JM, Reelin sets the pace of neocortical neurogenesis. Development. 2011 Dec;138(23):5223-34 |
4 | J:273200 Landin Malt A, Dailey Z, Holbrook-Rasmussen J, Zheng Y, Hogan A, Du Q, Lu X, Par3 is essential for the establishment of planar cell polarity of inner ear hair cells. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4999-5008 |
1 | J:306218 Landin Malt A, Hogan AK, Smith CD, Madani MS, Lu X, Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling. J Cell Biol. 2020 Oct 5;219(10) |
2 | J:308321 Lau EO, Damiani D, Chehade G, Ruiz-Reig N, Saade R, Jossin Y, Aittaleb M, Schakman O, Tajeddine N, Gailly P, Tissir F, DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. Elife. 2021 Apr 26;10:e61974 |
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7* | J:63704 Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T, A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000 Aug;2(8):540-7 |
1 | J:292113 Lin YN, Lee YS, Li SK, Tang TK, Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly. J Cell Sci. 2020 Jun 24;133(12):jcs243592 |
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1 | J:294113 Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE, Telophase correction refines division orientation in stratified epithelia. Elife. 2019 Dec 13;8:e49249 |
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1 | J:317544 Lyu J, Kim HR, Yamamoto V, Choi SH, Wei Z, Joo CK, Lu W, Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells. Cell Rep. 2013 Nov 14;5(3):593-600 |
1 | J:194042 Mahaffey JP, Grego-Bessa J, Liem KF Jr, Anderson KV, Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71 |
16* | J:78857 Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S, Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn. 2002 Sep;225(1):61-9 |
2 | J:229014 Marty-Santos L, Cleaver O, Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12 |
2* | J:196288 Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V, Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84 |
1 | J:306138 Nishiyama T, Fujioka M, Saegusa C, Oishi N, Harada T, Hosoya M, Saya H, Ogawa K, Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice. Biochem Biophys Res Commun. 2021 Jan 1;534:921-926 |
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1 | J:240000 Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S, The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46 |
1 | J:315122 Passer D, van de Vrugt A, Atmanli A, Domian IJ, Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation. Cell Rep. 2016 Feb 23;14(7):1662-1672 |
1 | J:178461 Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO, SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67 |
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